Whole blood spontaneous capillary flow in narrow V-groove microchannels

Berthier, Jean; Brakke, Kenneth A.; Furlani, Edward P.; Karampelas, Ioannis; Poher, V.; Gosselin, David C.; Cubizolles, Myriam; Pouteau, Patrick

doi:10.1016/j.snb.2014.09.040

Cited by 52 publications

(32 citation statements)

References 34 publications

(41 reference statements)

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“…The design of the microfluidic chip was optimized for passive injection of blood [ 24 ]. It is fabricated by the injection molding of cyclic olefin polymer (COP) (Cema, Le Mans, France).…”

Section: Methodsmentioning

confidence: 99%

Red Blood Cell Agglutination for Blood Typing Within Passive Microfluidic Biochips

2018

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Pre-transfusion bedside compatibility test is mandatory to check that the donor and the recipient present compatible groups before any transfusion is performed. Although blood typing devices are present on the market, they still suffer from various drawbacks, like results that are based on naked-eye observation or difficulties in blood handling and process automation. In this study, we addressed the development of a red blood cells (RBC) agglutination assay for point-of-care blood typing. An injection molded microfluidic chip that is designed to enhance capillary flow contained anti-A or anti-B dried reagents inside its microchannel. The only blood handling step in the assay protocol consisted in the deposit of a blood drop at the tip of the biochip, and imaging was then achieved. The embedded reagents were able to trigger RBC agglutination in situ, allowing for us to monitor in real time the whole process. An image processing algorithm was developed on diluted bloods to compute real-time agglutination indicator and was further validated on undiluted blood. Through this proof of concept, we achieved efficient, automated, real time, and quantitative measurement of agglutination inside a passive biochip for blood typing which could be further generalized to blood biomarker detection and quantification.

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“…The design of the microfluidic chip was optimized for passive injection of blood [ 24 ]. It is fabricated by the injection molding of cyclic olefin polymer (COP) (Cema, Le Mans, France).…”

Section: Methodsmentioning

confidence: 99%

Red Blood Cell Agglutination for Blood Typing Within Passive Microfluidic Biochips

2018

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“…Berthier et al presented the open triangular cross-section such as an interesting solution for capillary actuation of whole blood in the point-of-care systems domain [39]. These studies aimed to determine the appropriate parameters to accomplish spontaneous capillary flows, avoiding the use of costly actuation systems [20,32,39,40].…”

Section: Physical Confinementmentioning

confidence: 99%

Recent advances on open fluidic systems for biomedical applications: A review

Oliveira

Vilabril

Oliveira

et al. 2019

Materials Science and Engineering: C

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Microfluidics has become an important tool to engineer microenvironments with high precision, comprising devices and methods for controlling and manipulating fluids at the submillimeter scale. A specific branch of microfluidics comprises open fluidic systems, which is mainly characterized by displaying a higher air/liquid interface when compared with traditional closed-channel setups. The use of open channel systems has enabled the design of singular architectures in devices that are simple to fabricate and to clean. Enhanced functionality and accessibility for liquid handling are additional advantages inputted to technologies based on open fluidics. While benchmarked against closed fluidics approaches, the use of directly accessible channels decreases the risk of clogging and bubble-driven flow perturbation. In this review, we discuss the advantages of open fluidics systems when compared to their closed fluidics counterparts. Platforms are analyzed in two separated groups based on different confinement principles: wall-based physical confinement and wettability-contrast confinement. The physical confinement group comprises both open and traditional microfluidics; examples based on open channels with rectangular and triangular cross-section, suspended microfluidics, and the use of narrow edge of a solid surface for fluid confinement are addressed. The second group covers (super)hydrophilic/(super) hydrophobic patterned surfaces, and examples based on polymer-, textile-and paper-based microfluidic devices are explored. The technologies described in this review are critically discussed concerning devices' performance and versatility, manufacturing techniques and fluid transport/manipulation methods. A gather-up of recent biomedical applications of open fluidics devices is also presented.

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“…Mini-or microchannel heat exchangers are widely used in many industries: 1. the power industry (water cooled turbine blades, rocket nozzle cooling, fusion reactor blanket cooling, and domestic micro CHP) (Hall and Mudawar, 1999;Mikielewicz and Mikielewicz, 2010;Nacke et al, 2011;Ornatskii and Vinyarskii, 1965;Sturgis and Mudawar, 1999), 2. the electronics industry (microprocessors, LED cooling) (Bahiraei and Heshmatian, 2017;Jajja et al, 2014;Ramos-Alvarado et al, 2013), 3. the avionics industry (avionics cooling) (Najim and Feddaoui, 2018), 4. the space industry (cooling of satellite electronics) (Brutin et al, 2013), 5.the solar industry (solar, photovoltaic panels) (Robles et al, 2014;, 6. the automotive industry (multiport condensers) (Sakamatapan and Wongwises, 2014) , 7..the chemical and biological industry (Berthier et al, 2015;JY et al, 2015;P. Zhou et al, 2017), 8.. the refrigeration industry (microfin tubes in residential cooling, heat pumps) (García-Cascales et al, 2017;Illán-Gómez et al, 2017) and 9. the cryogenic industry (heat exchangers for hydrogen production systems) (Zhou et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Channel Blockage and Flow Maldistribution during Unsteady Flow in a Model Microchannel Plate heat Exchanger

Dąbrowski

Klugmann

Mikielewicz

2019

JAFM

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This paper describes the problem of channel blockage as a result of flow maldistribution between the channels of a model mini channel plate heat exchanger consisting of one pass on each leg. Each leg of the heat exchanger contains 51 parallel and rectangular minichannels of four hydraulic diameters namely 461 µm, 571 µm, 750 µm and 823 µm. In addition, a more complex geometry has been investigated where for the sake of breaking the development length the inclined transverse cuts have been incorporated. The moment of liquid phase transition through the exchanger (the working medium: water) was recorded for the mass fluxes ranging from 18.67 to 277.76 kg/m2s in 51 parallel channels with the use of a fast speed camera. The Reynolds numbers Re in the individual channels were from 10.76 to 90.04. The relationship between the mass flux and the size of the minichannels in the presence of the maldistribution is discussed here. The existence of the threshold in the mass flux below which the phenomenon occurs has been shown. Two mechanisms of channel blocking have been recorded and described in detail. A miniscale variation of one of them containing the extended geometry was created as well.

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Whole blood spontaneous capillary flow in narrow V-groove microchannels

Cited by 52 publications

References 34 publications

Red Blood Cell Agglutination for Blood Typing Within Passive Microfluidic Biochips

Red Blood Cell Agglutination for Blood Typing Within Passive Microfluidic Biochips

Recent advances on open fluidic systems for biomedical applications: A review

Channel Blockage and Flow Maldistribution during Unsteady Flow in a Model Microchannel Plate heat Exchanger

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