Whole blood reflectance for assessment of hematologic condition and detection of angiographic contrast media

Chang, Hyeonsoo; Kim, Young L.; Hassan, Ali; Fitzgerald, Peter J.

doi:10.1364/ao.48.002435

Cited by 7 publications

(8 citation statements)

References 41 publications

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“…39,40 Our intention of using the relative large-diameter optical probe was to minimize spectral variations associated the pressure exerted from the probe in contact with the tissue surface. [41][42][43][44][45] In particular, the effect of probe contact pressure is known to be significant with small-diameter miniature probes due to mechanical indentation effects.…”

Section: Methodsmentioning

confidence: 99%

Toward laboratory blood test-comparable photometric assessments for anemia in veterinary hematology

et al. 2016

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Abstract. Anemia associated with intestinal parasites and malnutrition is the leading cause of morbidity and mortality in small ruminants worldwide. Qualitative scoring of conjunctival redness has been developed so that farmers can gauge anemia in sheep and goats to identify animals that require treatment. For clinically relevant anemia diagnosis, complete blood count-comparable quantitative methods often rely on complicated and expensive optical instruments, requiring detailed spectral information of hemoglobin. We report experimental and numerical results for simple, yet reliable, noninvasive hemoglobin detection that can be correlated with laboratory-based blood hemoglobin testing for anemia diagnosis. In our pilot animal study using calves, we exploit the third eyelid (i.e., palpebral conjunctiva) as an effective sensing site. To further test spectrometerfree (or spectrometerless) hemoglobin assessments, we implement full spectral reconstruction from RGB data and partial least square regression. The unique combination of RGB-based spectral reconstruction and partial least square regression could potentially offer uncomplicated instrumentation and avoid the use of a spectrometer, which is vital for realizing a compact and inexpensive hematology device for quantitative anemia detection in the farm field.

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Section: Methodsmentioning

confidence: 99%

Toward laboratory blood test-comparable photometric assessments for anemia in veterinary hematology

et al. 2016

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“…Chang et al 16 measured the reflectance spectra with a specially designed fiber opticebased probe (Ocean Optics R400-7-UV-VIS, Dunedin, FL) ( Fig. 2A).…”

Section: The Principle Of Quantifying Tissue Oxygen Saturationmentioning

confidence: 99%

“…Chang et al 16 also measured whole blood reflectance spectra at various hematocrit (HCT) levels in porcine arterial blood samples ( Fig. 2B).…”

Section: The Principle Of Quantification Of Hb Amountmentioning

confidence: 99%

“…Each blood sample at different oxygen saturations has its own distinctive reflectance spectral shape. 16 (B) Whole blood reflectance spectra at various HCT levels of porcine arterial blood samples: the reflectance spectra are shifted up as the HCT level increases, and the spectral signals are saturated as the HCT level reaches the normal HCT level of 44%. Inset, changes in the reflectance intensity at 627 nm.…”

Section: Subjectsmentioning

confidence: 99%

“…[9][10][11][12][13][14][15] The reflected light of Hb has the characteristic of changing with the oxygen saturation and the amount of Hb. 16 We hypothesized that the blood flow status at the tissue could be accurately determined by quantitative imaging the degree of oxygen saturation and the amount of Hb in the tissue. Therefore, the multispectral device developed for this purpose could allow clinicians to distinguish whether the decreased oxygen saturation of the tissue is due to an Hb inflow disorder (ischemia) or an outflow disorder (congestion) or both.…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of Novel Multispectral Imaging Device to Determine Anastomosis for Esophagogastrostomy

Tsutsumi

Ikeda

Nagahara

et al. 2019

Journal of Surgical Research

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Background: Biomedical imaging devices that utilize the optical characteristics of hemoglobin (Hb) have become widespread. In the field of gastroenterology, there is a strong demand for devices that can apply this technique to surgical navigation. We aimed to introduce our novel multispectral device capable of intraoperatively performing quantitative imaging of the oxygen (O 2) saturation and Hb amount of tissues noninvasively and in real time, and to examine its application for deciding the appropriate anastomosis point after subtotal or total esophagectomy. Materials and methods: A total of 39 patients with esophageal cancer were studied. Tissue O 2 saturation and Hb amount of the gastric tube just before esophagogastric anastomosis were evaluated using a multispectral tissue quantitative imaging device. The anastomosis point was decided depending on the quantitative values and patterns of both the tissue O 2 saturation and Hb amount. Results: The device can instantaneously and noninvasively quantify and visualize the tissue O 2 saturation and Hb amount using reflected light. The tissue Hb status could be classified into the following four types: good circulation type, congestion type, ischemia type, and mixed type of congestion and ischemia. Postoperative anastomotic failure occurred in 2 cases, and both were mixed cases. Conclusions: The method of quantitatively imaging the tissue O 2 saturation and Hb level in real time and noninvasively using a multispectral device allows instantaneous determination of the anastomosis and related organ conditions, thereby contributing to determining the appropriate treatment direction.

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Novel Multispectral Device for Quantitative Imaging of Tissue Oxygen Saturation and Hemoglobin as Surgical Navigation Device

Haruta

Tsutsumi

Kuriyama

et al. 2020

Surgery and Operating Room Innovation

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Whole blood reflectance for assessment of hematologic condition and detection of angiographic contrast media

Cited by 7 publications

References 41 publications

Toward laboratory blood test-comparable photometric assessments for anemia in veterinary hematology

Toward laboratory blood test-comparable photometric assessments for anemia in veterinary hematology

Efficacy of Novel Multispectral Imaging Device to Determine Anastomosis for Esophagogastrostomy

Novel Multispectral Device for Quantitative Imaging of Tissue Oxygen Saturation and Hemoglobin as Surgical Navigation Device

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