Whole Blood Platelet Aggregation and Release Reaction Testing in Uremic Patients

Zeck, Jay; Schallheim, Jason; Lew, Susie Q.; DePalma, Louis

doi:10.1155/2013/486290

Cited by 20 publications

(15 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Importantly, this is the first large study to date to report platelet dysfunction in patients with CKD using whole blood impedance aggregometry such as MEA. Other researchers have drawn similar conclusions using a far less number of subjects and different measuring devices .…”

Section: Discussionsupporting

confidence: 58%

Routine haemostasis testing before transplanted kidney biopsy: a cohort study

et al. 2017

View full text Add to dashboard Cite

Summary Kidney biopsy can result in bleeding complications. Prebiopsy testing using bleeding time (BT) is controversial. New whole blood haemostasis tests, such as platelet function analyser‐100 (PFA‐100) and multiple electrode aggregometry (MEA), might perform better. We postulated that PFA‐100 would be suitable to replace BT prebiopsy. In 154 patients, transplanted kidney biopsies were performed after measurement of bleeding time, PFA‐100, MEA and mean platelet volume (MPV). Bleeding outcome (haemoglobin (Hb) drop, haematuria (±bladder catheterization), ultrasound finding of a bleeding, need for (non)surgical intervention and/or transfusion) after the biopsy was correlated to each test. Male–female ratio was 2:1. 50% had a surveillance biopsy at either three or 12 months. Around 17% (had) used acetylsalicylic acid (ASA) prebiopsy. Of 17 bleeding events, one subject needed a transfusion. Most bleeding events were Hb reductions over 1 mmol/l and all resolved uneventful. BT, PFA‐100, MEA and MPV did not predict a bleeding outcome; prior ASA use however could (odds ratio 3.19; 95%‐CI 1.06 to 9.61). Diagnostic performance data and Bland–Altman analysis showed that BT could not be substituted by PFA‐100. ASA use was the best determinant of bleeding after kidney biopsy. Routine haemostasis testing prebiopsy has no added value.

show abstract

Section: Discussionsupporting

confidence: 58%

Routine haemostasis testing before transplanted kidney biopsy: a cohort study

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Antiplatelet therapy such as aspirin inhibits platelet-derived thromboxane A 2 (TXA 2 ) synthesis [35]. TXA 2 production is linked to the release of ATP that in turn leads to the activation of platelets [36]. Park et al [37] have reported that elevated NO production inhibited the release of ATP derived from platelet in an animal model.…”

Section: Discussionmentioning

confidence: 99%

Effect of Antithrombotic Therapy and Long Endoscopic Submucosal Dissection Procedure Time on Early and Delayed Postoperative Bleeding

et al. 2017

View full text Add to dashboard Cite

Background: Recent updated guidelines of the Japanese Society of Gastroenterology recommend the use of a single dose of antiplatelet agents in patients undergoing endoscopic submucosal dissection (ESD). However, the postoperative bleeding risk after gastric ESD associated with the continuation or interruption of antithrombotic therapy remains controversial. We aimed to evaluate whether certain factors including interrupted antithrombotic therapy could affect early and delayed post-ESD bleeding risk. Methods: Three hundred sixty-four patients with gastric neoplasms were treated with ESD at our hospital between October 2005 and December 2012. Seventy-four patients with interrupted antithrombotic therapy were undertaken with ESD. Early and delayed postoperative bleeding patterns were estimated. Various clinical characteristics such as gender, age, tumor location, tumor size, ESD procedure time, platelet count, and comorbidity were evaluated. Results: There was a significant difference (p = 0.042) in the ESD procedure time between the patients with postoperative bleeding and those without it. There was no significant difference in postoperative bleeding between the patients on antithrombotic therapy and not on it. Moreover, interrupted antithrombotic therapy and platelet count were significantly (p = 0.0461 and p = 0.0059, respectively) associated with early postoperative bleeding in multivariate analysis. In addition, in univariate analysis, ESD procedure time was significantly (p = 0.041) associated with delayed postoperative bleeding. Conclusions: Antithrombotic therapy and prolonged ESD procedure time were significantly associated with early and delayed postoperative bleeding, respectively.

show abstract

“…138) and also in blood platelet aggregation. 139 Like ATP, polyP contains high-energy phosphate units, linked via energy-rich phosphoanhydride bonds; 76,140 Fig. 5.…”

Section: Generation Of Adp/atpmentioning

confidence: 99%