Whole Blood Manganese Correlates with High Signal Intensities on T1-Weighted MRI in Patients with Liver Cirrhosis

Park, Neung Hwa; Park, Ji Kang; Choi, Yu-Sung; Yoo, Cheol-In; Lee, Choong Ryeol; Lee, Hun; Kim, Hyo Kyung; Kim, Sung-Ryul; Jeong, Tae Heum; Park, Jungsun; Yoon, Chung Sik; Kim, Yangho

doi:10.1016/s0161-813x(03)00111-6

Cited by 64 publications

(36 citation statements)

References 31 publications

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“…Nelson et al (1993) were the first to report increased signal intensities in a patient with occupational Mn neurointoxication. A similar MRI pattern has also been observed in patients receiving total parenteral nutrition (TPN) by direct intravenous administration (Ejima et al, 1992;Mirowitz et al, 1991) and in patients with portal systemic shunts such as individuals with liver cirrhosis, leading to an inability to clear Mn via biliary excretion (Butterworth et al, 1995;Hauser et al, 1994Hauser et al, , 1996Krieger et al, 1995;Park et al, 2003;Spahr et al, 1996). A high pallidal signal is very frequently observed in patients with established liver cirrhosis, but who lack exposure to Mn .…”

supporting

confidence: 55%

Neuroimaging in Manganese-Induced Parkinsonism

Kim¹

2011

Diagnostics and Rehabilitation of Parkinson's Disease

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supporting

confidence: 55%

Neuroimaging in Manganese-Induced Parkinsonism

Kim¹

2011

Diagnostics and Rehabilitation of Parkinson's Disease

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“…The mean pallidal index was calculated as the average ratio of GP signal intensity to the frontal WM bilaterally. 25 …”

Section: Calculating the Pallidal Indexmentioning

confidence: 99%

Significant Volume Reduction and Shape Abnormalities of the Basal Ganglia in Cases of Chronic Liver Cirrhosis

Lin

Chou

Chen

et al. 2011

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:Chronic liver disease frequently includes cognitive and movement disorders, suggesting an alteration of the striatum. With the exception of hyperintensities evident on T1-weighted images indicative of Mn deposition, radiographic findings of the BG are nonspecific. Volumetric and morphometric analysis of DGM is limited. Whether DGM undergoes degeneration and whether this change is associated with pallidal hyperintensity and cognitive performance are currently unknown in patients with cirrhosis.

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“…Because of the paramagnetic quality of Mn, the bilateral symmetrical increase in signal intensities, confined to the globus pallidus and midbrain, can be observed on T1-weighted MRI, but with no alteration on the T2-weighted image (Fig. 1) 5) . The increased signal in T1-weighted images was observed in the experimental Mn poisoning of the non-human primate 8,9) .…”

Section: Introductionmentioning

confidence: 99%

“…Several valuable studies [1][2][3][4][5][6] have been published on the relation of manganese (Mn) exposure with high signal intensities on T1-weighted brain magnetic resonance images (MRI) in Korea since the detection of high signals in Korean welders exposed to Mn in 1997. However, the fact that high signal intensities on T1-weighted MRI can be a useful biomarker of exposure to Mn was relatively unknown in the field of occupational medicine.…”

Section: Introductionmentioning

confidence: 99%

High Signal Intensities on T1-Weighted MRI as a Biomarker of Exposure to Manganese.

Kim

2004

INDUSTRIAL HEALTH

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Increased signal in T1-weighted images was observed in the experimental manganese (Mn) poisoning of the non-human primate and a patient with Mn neurointoxication. However, our study showed that the increased signals in magnetic resonance images (MRI) were highly prevalent (41.6%) in Mn-exposed workers. Especially 73.5% of the welders showed increased signal intensities. Blood Mn concentration correlated with pallidal index. These changes in MRI tend to disappear following the withdrawal from the source of Mn accumulation, despite permanent neurological damage. Thus increased signal intensities on a T1-weighted image reflect exposure to Mn, but not necessarily manganism. Our study also showed that the concentration of Mn required to produce increased signal intensities on MRI is much lower than the threshold necessary to result in overt clinical signs of manganism. Increased signal intensities in the globus pallidus were determined by Mn accumulation in the animal experiment. All these results strongly suggest that signal intensities in T1-weighted MRI reflect a target site dose in a biologically-based dose-response model. At which increase of signal intensity, the progression of manganism from Mn exposure occurs, however, remains to be solved.

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Whole Blood Manganese Correlates with High Signal Intensities on T1-Weighted MRI in Patients with Liver Cirrhosis

Cited by 64 publications

References 31 publications

Neuroimaging in Manganese-Induced Parkinsonism

Neuroimaging in Manganese-Induced Parkinsonism

Significant Volume Reduction and Shape Abnormalities of the Basal Ganglia in Cases of Chronic Liver Cirrhosis

High Signal Intensities on T1-Weighted MRI as a Biomarker of Exposure to Manganese.

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