Whole Blood Gene Expression And Serum Biomarker Profiling In A COPD Cohort Identifies Markers Related To Neutrophilic Inflammation, Wound Healing And Altered B Cell Signaling

Cockayne, Debra A.; Cheng, Donavan T.; Waschki, Benjamin; Hilton, Holly; Kourteva, Galina; Sridhar, Srinivas; Ravindran, Palani; Bitter, Hans; Visvanathan, Sudha; Mueller, Kai-Christian; Holz, Olaf; Magnussen, H; Watz, Henrik; Fine, Jay S.

doi:10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a4091

Cited by 2 publications

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“…We found that the hub protein, CD79A, was enriched with lymphocyte activation. CD79A has been demonstrated to play diverse roles in the development and function of B lymphocytes (Pelanda et al 2002) and may be downregulated in severe COPD when compared with controls (Cockayne et al 2011). Our results showed that CD79A was negatively correlated with the clinical classification of COPD.…”

Section: Discussionmentioning

confidence: 53%

Peer Review #1 of "Identification of biomarkers associated with clinical severity of chronic obstructive pulmonary disease (v0.1)"

2020

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Section: Discussionmentioning

confidence: 53%

Peer Review #1 of "Identification of biomarkers associated with clinical severity of chronic obstructive pulmonary disease (v0.1)"

2020

View full text Add to dashboard Cite

“…We found that the hub protein, CD79A, was enriched with lymphocyte activation. CD79A has been demonstrated to play diverse roles in the development and function of B lymphocytes ( Pelanda et al., 2002 ) and may be downregulated in severe COPD when compared with controls ( Cockayne et al, 2011 ). Our results showed that CD79A was negatively correlated with the clinical classification of COPD.…”

Section: Discussionmentioning

confidence: 99%

Identification of biomarkers associated with clinical severity of chronic obstructive pulmonary disease

Zhang

Chang-li

Gao

et al. 2020

PeerJ

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We sought to identify the biomarkers related to the clinical severity of stage I to stage IV chronic obstructive pulmonary disease (COPD). Gene expression profiles from the blood samples of COPD patients at each of the four stages were acquired from the Gene Expression Omnibus Database (GEO, accession number: GSE54837). Genes showing expression changes among the different stages were sorted by soft clustering. We performed functional enrichment, protein–protein interaction (PPI), and miRNA regulatory network analyses for the differentially expressed genes. The biomarkers associated with the clinical classification of COPD were selected from logistic regression models and the relationships between TLR2 and inflammatory factors were verified in clinical blood samples by qPCR and ELISA. Gene clusters demonstrating continuously rising or falling changes in expression (clusters 1, 2, and 7 and clusters 5, 6, and 8, respectively) from stage I to IV were defined as upregulated and downregulated genes, respectively, and further analyzed. The upregulated genes were enriched in functions associated with defense, inflammatory, or immune responses. The downregulated genes were associated with lymphocyte activation and cell activation. TLR2, HMOX1, and CD79A were hub proteins in the integrated network of PPI and miRNA regulatory networks. TLR2 and CD79A were significantly correlated with clinical classifications. TLR2 was closely associated with inflammatory responses during COPD progression. Functions associated with inflammatory and immune responses as well as lymphocyte activation may play important roles in the progression of COPD from stage I to IV. TLR2 and CD79A may serve as potential biomarkers for the clinical severity of COPD. TLR2 and CD79A may also serve as independent biomarkers in the clinical classification in COPD. TLR2 may play an important role in the inflammatory responses of COPD.

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Whole Blood Gene Expression And Serum Biomarker Profiling In A COPD Cohort Identifies Markers Related To Neutrophilic Inflammation, Wound Healing And Altered B Cell Signaling

Cited by 2 publications

References 0 publications

Peer Review #1 of "Identification of biomarkers associated with clinical severity of chronic obstructive pulmonary disease (v0.1)"

Peer Review #1 of "Identification of biomarkers associated with clinical severity of chronic obstructive pulmonary disease (v0.1)"

Identification of biomarkers associated with clinical severity of chronic obstructive pulmonary disease

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