Whole blood and plasma water in health and disease: longitudinal and transverse observations and correlations with several different hematological and clinicochemical parameters

Beijering, Rjr; Gips, Ch; Huizenga, [No Value]; Jäger, J; Mackor, A.J.; Salomons, H; Knol, Edward F.; Lijnema, T.H.

doi:10.1016/s0009-8981(96)06428-5

Cited by 9 publications

(9 citation statements)

References 4 publications

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“…An important question is whether there are known mechanisms that might underlie these results if the associations are causal. There is a small literature strongly suggesting that several factors related to blood viscosity are adversely affected by hypohydration (16)(17)(18)(19)(20)(21)(35)(36)(37)(38)(39) and that these rheologic factors predict the risk of coronary heart disease (4,6,8,9). Whole blood viscosity is determined mainly by hematocrit and fibrinogen levels, both of which have frequently been associated with coronary heart disease events (1)(2)(3)(4)(5)(6)(7)(8)(9).…”

Section: Discussionmentioning

confidence: 99%

Water, Other Fluids, and Fatal Coronary Heart Disease: The Adventist Health Study

Chan

Knutsen²,

Blix³

et al. 2002

American Journal of Epidemiology

143

123

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Whole blood viscosity, plasma viscosity, hematocrit, and fibrinogen are considered independent risk factors for coronary heart disease and can be elevated by dehydration. The associations between fatal coronary heart disease and intake of water and fluids other than water were examined among the 8,280 male and 12,017 female participants aged 38-100 years who were without heart disease, stroke, or diabetes at baseline in 1976 in the Adventist Health Study, a prospective cohort study. A total of 246 fatal coronary heart disease events occurred during the 6-year follow-up. High daily intakes of water (five or more glasses) compared with low (two or fewer glasses) were associated with a relative risk in men of 0.46 (95% confidence interval (CI): 0.28, 0.75; p trend = 0.001) and, in women, of 0.59 (95% CI: 0.36, 0.97). A high versus low intake of fluids other than water was associated with a relative risk of 2.47 (95% CI: 1.04, 5.88) in women and of 1.46 (95% CI: 0.7, 3.03) in men. All associations remained virtually unchanged in multivariate analysis adjusting for age, smoking, hypertension, body mass index, education, and (in women only) hormone replacement therapy. Fluid intake as a putative coronary heart disease risk factor may deserve further consideration in other populations or using other study designs.

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Section: Discussionmentioning

confidence: 99%

Water, Other Fluids, and Fatal Coronary Heart Disease: The Adventist Health Study

Chan

Knutsen²,

Blix³

et al. 2002

American Journal of Epidemiology

143

123

View full text Add to dashboard Cite

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“…Copeptin, the C-terminal part of the vasopressin prohormone, and N-terminal pro-B-type natriuretic peptide (NTproBNP), an established marker for left ventricular function and the prognosis of myocardial infarction, were at highest levels at admission then plateaued within 3–5 d; moreover, their levels were higher in patients who died or were readmitted for heart failure than in survivors ( 20 ) . Another mechanism was shown in a clinical trial of 293 healthy men and women aged 20–95 years which demonstrated that hypo-hydration leads to high blood viscosity ( 27 ) , which was positively associated with 8-year risk of CHD among 933 men aged 45–64 years of the MONICA-Augsburg cohort study ( 28 ) . Among 4112 men and women aged ≥20 years in NHANES 1999–2006, individuals with high water intakes either from plain water or from foods and beverages had healthier lifestyles, such as high physical activity, high education and high fibre intake, and lower sugar intake, than individuals with low water intakes ( 29 ) .…”

Section: Discussionmentioning

confidence: 99%

Water intake from foods and beverages and risk of mortality from CVD: the Japan Collaborative Cohort (JACC) Study

Cui

Iso

Eshak

et al. 2018

Public Health Nutr.

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“…The suggested mechanisms explaining the reduced risk of CVD associated with higher intakes of total non-alcoholic beverages could be the same anti-hypohydration effect and involvement in the role of the vasopressin system as those of total fluid intake. Hypohydration-initiated high blood viscosity (28) was associated with an increased risk of CHD in the 8-year follow-up of 933 German men aged 45-64 years; the multivariable HR (95 % CI) in the highest v. lowest quintiles of blood viscosity was 2•68 (1•48, 4•88) (29) . The NHANES indicated that persons with larger total fluid intake had healthier lifestyles, such as being physically active and consuming high-fibre and low-sugar diets (30) .…”

Section: Mechanisms For Non-alcoholic Beverages Intake and Cvdmentioning

confidence: 95%

“…Hypohydration-initiated high blood viscosity (28) was associated with an increased risk of coronary heart disease in the 8-year follow-up of 933 German men aged 45-64 years; the multivariable HR (95% CI) in the highest versus lowest quintiles of blood viscosity was 2.68 healthier lifestyles, such as being physically active, and consuming of high fiber and low sugar diets (30) . In addition, the major sources of non-alcoholic beverages in the present study were the green tea and coffee, which were associated with reduced risks of diabetes (31,32) and cardiovascular disease (33,24) .…”

Section: Mechanisms For Non-alcoholic Beverages Intake and Cardiovascular Diseasementioning

confidence: 99%

Non-alcoholic beverages intake and risk of CVD among Japanese men and women: the Japan Public Health Center study

et al. 2021

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The association between the intake of non-alcoholic beverages and cardiovascular disease in Asians is uncertain. The intake of non-alcoholic beverages was estimated in 77,407 participants of the Japan public health center-based cohort study aged 45-74 years. The Cox regression calculated the HRs and 95% CIs for incident cardiovascular disease according to sex-specific quintiles of intake of non-alcoholic beverages. A total of 4578 incident cardiovascular disease (3,751 strokes and 827 coronary heart disease) were diagnosed during a 13.6-year median follow-up. The risks of stroke and total cardiovascular disease were lower for the highest versus lowest intake quintiles of non-alcoholic beverages in men and women: the multivariable HRs (95%CIs) were 0.82 (0.71-0.93, p-trend=0.005) and 0.86 (0.76-0.97, p-trend=0.02), respectively in men, and were 0.73 (0.63-0.86, p-trend=0.003) and 0.75 (0.65-0.87, p-trend=0.005) respectively in women. The reduced risk was evident for both ischemic and hemorrhagic strokes and was mainly attributable to green tea consumption. The intake of non-alcoholic beverages from coffee and other beverages was not associated with the risk of cardiovascular disease in both men and women. Also, there was no association between the intake of non-alcohol beverages and the risk of coronary heart disease in either sex. In conclusion, the risks of stroke and total cardiovascular disease were lower with a higher intake of non-alcoholic beverages in Japanese men and women.

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Whole blood and plasma water in health and disease: longitudinal and transverse observations and correlations with several different hematological and clinicochemical parameters

Cited by 9 publications

References 4 publications

Water, Other Fluids, and Fatal Coronary Heart Disease: The Adventist Health Study

Water, Other Fluids, and Fatal Coronary Heart Disease: The Adventist Health Study

Water intake from foods and beverages and risk of mortality from CVD: the Japan Collaborative Cohort (JACC) Study

Non-alcoholic beverages intake and risk of CVD among Japanese men and women: the Japan Public Health Center study

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