Whole anterior segment and retinal swept source OCT for comprehensive ocular screening

Rodríguez-Aramendía, Ana; Díaz-Doutón, Fernando; Fernández-Trullàs, José; Falgueras, Pol; González, Laura; Pujol, Jaume; Grulkowski, Ireneusz; Güell, José L.

doi:10.1364/boe.414592

Cited by 11 publications

(6 citation statements)

References 40 publications

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“…Compared to slit lamp examinations, we found that LDH offers a better contrast of opacities, is not operator-dependent, highly repeatable, comfortable for the subject, and enables to document the anterior segment transparency over the whole pupil with a single image. A limitation of LDH is that the large depth of field of the reconstructed holograms does not allow to identify the axial position of the opaque structure as OCT is able to in the anterior segment [51][52][53][54]. LDH may also not be the most promising approach to image the cornea with cellular resolution [55][56][57][58][59].…”

Section: Discussionmentioning

confidence: 99%

Laser Doppler holography of the anterior segment for blood flow imaging, eye tracking, and transparency assessment

Puyo,

David,

Saad

et al. 2021

Preprint

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Laser Doppler holography (LDH) is a full-field blood flow imaging technique able to reveal human retinal and choroidal blood flow with high temporal resolution. We here report on using LDH in the anterior segment of the eye without making changes to the instrument. Blood flow in the bulbar conjunctiva and episclera as well as in corneal neovascularization can be effectively imaged. We additionally demonstrate simultaneous holographic imaging of the anterior and posterior segments by simply adapting the numerical propagation distance to the plane of interest. We used this feature to track the movements of the retina and pupil with high temporal resolution. Finally, we show that the light backscattered by the retina can be used for retro-illumination of the anterior segment. Hence digital holography can reveal opacities caused by absorption or diffusion in the cornea and eye lens.

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Section: Discussionmentioning

confidence: 99%

Laser Doppler holography of the anterior segment for blood flow imaging, eye tracking, and transparency assessment

Puyo,

David,

Saad

et al. 2021

Preprint

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“…For anterior segment, imaging light has to pass only through the air to the tissue of interest versus the refractive structures (cornea and lens) for retinal imaging. The scan depth using standard OCT is typically about 2 mm, well below the typical axial length of the eye ( 188 ). Whole-eye OCT offers the opportunity to acquire a view of the eye from anterior to posterior segments with a single scan.…”

Section: Optical Coherence Tomographymentioning

confidence: 99%

The Development and Clinical Application of Innovative Optical Ophthalmic Imaging Techniques

et al. 2022

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The field of ophthalmic imaging has grown substantially over the last years. Massive improvements in image processing and computer hardware have allowed the emergence of multiple imaging techniques of the eye that can transform patient care. The purpose of this review is to describe the most recent advances in eye imaging and explain how new technologies and imaging methods can be utilized in a clinical setting. The introduction of optical coherence tomography (OCT) was a revolution in eye imaging and has since become the standard of care for a plethora of conditions. Its most recent iterations, OCT angiography, and visible light OCT, as well as imaging modalities, such as fluorescent lifetime imaging ophthalmoscopy, would allow a more thorough evaluation of patients and provide additional information on disease processes. Toward that goal, the application of adaptive optics (AO) and full-field scanning to a variety of eye imaging techniques has further allowed the histologic study of single cells in the retina and anterior segment. Toward the goal of remote eye care and more accessible eye imaging, methods such as handheld OCT devices and imaging through smartphones, have emerged. Finally, incorporating artificial intelligence (AI) in eye images has the potential to become a new milestone for eye imaging while also contributing in social aspects of eye care.

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“…A wide variety of approaches have been proposed to overcome this physical limitation by imaging each ocular segment either sequentially or simultaneously within the same acquisition of a subject's eye. For sequential imaging of each ocular segment the use of mechanical actuators (e.g., a bi-stable rotary solenoid [19], or a fold mirror [20]) has been proposed to switch between two static sample arm configurations suitable for each segment. Alternatively, the split between two static sample arm configurations has been achieved optically.…”

Section: Introductionmentioning

confidence: 99%

An optical beam scanner with reconfigurable non mechanical control of beam position, angle and focus for low-cost whole-eye OCT imaging

Urizar¹,

Gambra²,

Peña³

et al. 2023

Preprint

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Whole-eye optical coherence tomography (OCT) imaging is a promising tool in ocular biometry for cataract surgery planning, glaucoma diagnostics and myopia progression studies. However, conventional OCT systems are set up to perform either anterior or posterior eye segment scans and cannot easily switch between the two scan configurations without adding or exchanging optical components to account for the refraction of the eye’s optics. Even in state-of-the-art whole-eye OCT systems, the scan configurations are pre-selected and cannot be dynamically reconfigured. In this work, we present the design, optimization and experimental validation of a reconfigurable and low-cost optical beam scanner based on three electro-tunable lenses, capable of non-mechanically controlling the beam position, angle and focus. We derive the analytical theory behind its control. We demonstrate its use in performing alternate anterior and posterior segment imaging by seamlessly switching between a telecentric focused beam scan to an angular collimated beam scan. We characterize the corresponding beam profiles and record whole-eye OCT images in a model eye and in an ex vivo rabbit eye, observing features comparable to those obtained with conventional anterior and posterior OCT scanners. The proposed beam scanner reduces the complexity and cost of other whole-eye scanners and is well suited for 2-D ocular biometry. Additionally, with the added versatility of seamless scan reconfiguration, its use can be easily expanded to other ophthalmic applications and beyond.

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Whole anterior segment and retinal swept source OCT for comprehensive ocular screening

Cited by 11 publications

References 40 publications

Laser Doppler holography of the anterior segment for blood flow imaging, eye tracking, and transparency assessment

Laser Doppler holography of the anterior segment for blood flow imaging, eye tracking, and transparency assessment

The Development and Clinical Application of Innovative Optical Ophthalmic Imaging Techniques

An optical beam scanner with reconfigurable non mechanical control of beam position, angle and focus for low-cost whole-eye OCT imaging

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