Who was first to diagnose and report neuropathic arthropathy of the foot and ankle: Jean-Martin Charcot or Herbert William Page?

Sanders, Lee J.; Edmonds, Michael; Jeffcoate, William

doi:10.1007/s00125-013-2961-6

Cited by 10 publications

(6 citation statements)

References 8 publications

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“…Perhaps the most accurate term that could be used is 'neuropathic inflammatory sarco-osteoarthropathy', but it is easier to refer to the condition simply as the Charcot foot or Charcot foot syndrome. Similar inflammation-based changes were first described in larger joints of the lower limb and spine by Jean-Martin Charcot in 1868, but involvement of the foot was not described until 1881, by an English surgeon, Herbert William Page [6]. Charcot's own description of the disease affecting the foot did not appear until 1883.…”

Section: What's In a Name?mentioning

confidence: 78%

Charcot foot syndrome

Jeffcoate

2015

Diabet. Med.

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Charcot foot syndrome is an uncommon complication of diabetes but is potentially devastating in its consequences. Outcome is made worse by widespread professional ignorance leading to delayed diagnosis, but it is also hampered by lack of understanding of its causes and lack of treatments with proven effectiveness, other than offloading. There remains a desperate need for studies into its causes as well as comparative audit and trials designed to determine the best treatment for this difficult condition. Such work can probably only be effectively carried out through the establishment of multicentre networks. Nevertheless, improved understanding in recent years of the likely role of inflammatory pathways has raised awareness of the multiple ways in which the effects of neuropathy may be manifest in the development of the Charcot foot. This awareness is also leading to the realization that similar processes may conceivably contribute to the refractoriness of other foot diseases in diabetes, including both chronic unhealing ulcers and osteomyelitis.

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Section: What's In a Name?mentioning

confidence: 78%

Charcot foot syndrome

Jeffcoate

2015

Diabet. Med.

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“…i brojne metaboličke bolesti (giht, pseudogiht, alkaptonurija, hemosideroza). Tipičan primer artropatije je Šarkoov zglob (najčešće kao neuroartropatija ili dijabetska artropatija) [24]. Zajedničko za sve ove bolesti je da se osnovni patološki proces nalazi izvan zglobova, a da su oni oštećeni sekundarno.…”

Section: Savremena Razmatranjaunclassified

Osteoarthritis, osteoarthrosis and osteoarthropathy: What is the difference?

Jeremić¹,

Gluscevic²,

Rajković³

et al. 2021

Srpski medicinski časopis Lekarske komore

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Osteoarthritis, osteoarthrosis, and osteoarthropathy are diseases that doctors encounter daily in their practice. The use of all three terms is customary, often without a clear justification as to why a particular term is used for a particular case. In the past several decades, doctors mainly differentiated among these diseases based on clinical presentation and radiography. In the past several years, however, significant progress has been made in the field of biochemical, immunological, and cytohistological research, which has provided explanations for the pathogenesis of these conditions, enabled defining differences amongst them and facilitated the use of appropriate terms for each one of these diseases. The term arthritis (osteoarthritis) should be used exclusively for primarily inflammatory joint diseases-rheumatoid arthritis, juvenile arthritis, reactive arthritis (Reiter's syndrome). If the etiology is infectious, this must also be emphasized-septic (purulent) arthritis, tuberculous arthritis. Arthrosis (osteoarthrosis) relates to changes in the joints occurring due to pathological processes within the joint itself, but which, in their basis, are not inflammatory. Arthropathy is a term for joint disease stemming from another diseased organ or system of organs.

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“…And neuropathic arthropathy is named after the French neurologist Jean-Martin Charcot (1825 to 1893), who firstly described the condition in 1868 as a complication of patients with tabes dorsalis [ 2 ]. However, the neuropathic inflammatory osteoarthropathy associated with the foot was firstly reported in 1881 by an English surgeon, Herbert William Page [ 3 ]. In 1936, Jordan was the first to describe Charcot in diabetes [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Pathogenesis and potential relative risk factors of diabetic neuropathic osteoarthropathy

et al. 2017

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Diabetic neuropathic osteoarthropathy (DNOAP) is an uncommon, but with considerable morbidity and mortality rates, complication of diabetes. The real pathogenesis is still unclear. The two popular theories are the neuro-vascular theory and neuro-traumatic theory. Most theories and pathways focused on the uncontrolled inflammations that resulted in the final common pathway, receptor activator of nuclear factor κβ ligand (RANKL)/osteoprotegerin (OPG) axis, for the decreased bone density in DNOAP with an osteoclast and osteoblast imbalance. However, the RANKL/OPG pathway does not explain all the changes, other pathways and factors also play roles. A lot of DNOAP potential relative risk factors were evaluated and reported in the literature, including age, gender, weight, duration and type of diabetes, bone mineral density, peripheral neuropathy and arterial disease, trauma history, and some others. However, most of them are still in debates. Future studies focus on the pathogenesis of DNOAP are still needed, especially for the genetic factors. And, the relationship between DNOAP and those potential relative risk factors are still need to further clarify.

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Who was first to diagnose and report neuropathic arthropathy of the foot and ankle: Jean-Martin Charcot or Herbert William Page?

Cited by 10 publications

References 8 publications

Charcot foot syndrome

Charcot foot syndrome

Osteoarthritis, osteoarthrosis and osteoarthropathy: What is the difference?

Pathogenesis and potential relative risk factors of diabetic neuropathic osteoarthropathy

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