Who Turned Out the Lights? An Impressive Case of Melanosis Coli

Cowley, Kevin; Jennings, H. Whitney; Passarella, Michael

doi:10.14309/crj.2015.85

Cited by 5 publications

(2 citation statements)

References 5 publications

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“…As knowledge has progressed, it was found that patients with MC had a high adenoma detection rate, which may be related to the deep pigmented background of the intestinal mucosa in MC patients because this pigment increases the visibility of adenomas (7). However, there is ongoing debate about whether MC increases the risk of colon cancer (8)(9)(10)(11). Van Gorkon et al (12) found that anthraquinone laxative can enhance cell proliferation activity, inhibit cell apoptosis, and may promote cell carcinogenesis.…”

Section: Discussionmentioning

confidence: 99%

Case report: Melanosis coli combined with colon cancer, causality or coincidence?

et al. 2022

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The habitual use of laxative containing anthraquinone glycosides is considered to be the main cause of melanosis coli (MC). In the past, most scholars considered MC to be a benign and reversible disease. However, new evidence has emerged that MC may increase the risk of colon cancer. Here, we report a case of a 48-year-old woman diagnosed with MC and colon cancer. Through a literature review of previous basic and clinical studies, we summarize existing evidence that reveals the possible association between MC and colon cancer. Although this case cannot establish causality between MC and colon cancer, a high level of clinical vigilance for occurrence of colon cancer in patients with MC should be maintained.

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Section: Discussionmentioning

confidence: 99%

Case report: Melanosis coli combined with colon cancer, causality or coincidence?

et al. 2022

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“…Patients with MC are likely to experience colon polyps [1] and require close tracking with colonoscopies. The mechanism underlying anthraquinone-containing drug-related MC and colorectal hyperplasia polyps [1,2] involves the conversion of anthraquinone to lipofuscin, which causes mild inflammation in these cells and eventually leading to black or dark brown mucosal appearance on colonoscopy [3].…”

Section: Introductionmentioning

confidence: 99%

Quantitative Analysis of Melanosis Coli Colonic Mucosa Using Textural Patterns

Chen

Yeh

et al. 2020

Applied Sciences

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Melanosis coli (MC) is a disease related to long-term use of anthranoid laxative agents. Patients with clinical constipation or obesity are more likely to use these drugs for long periods. Moreover, patients with MC are more likely to develop polyps, particularly adenomatous polyps. Adenomatous polyps can transform to colorectal cancer. Recognizing multiple polyps from MC is challenging due to their heterogeneity. Therefore, this study proposed a quantitative assessment of MC colonic mucosa with texture patterns. In total, the MC colonoscopy images of 1092 person-times were included in this study. At the beginning, the correlations among carcinoembryonic antigens, polyp texture, and pathology were analyzed. Then, 181 patients with MC were extracted for further analysis while patients having unclear images were excluded. By gray-level co-occurrence matrix, texture patterns in the colorectal images were extracted. Pearson correlation analysis indicated five texture features were significantly correlated with pathological results (p < 0.001). This result should be used in the future to design an instant help software to help the physician. The information of colonoscopy and image analystic data can provide clinicians with suggestions for assessing patients with MC.

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