Who is taking their tablets?

An investigation of dapsone compliance using an isoniazid-marked formulation

“…Studies conducted among volunteers showed that 6 mg doses ofINH gave reliably positive urine-test results up to about 18 h and uniformly negative results fr om 48 h onwards. 9 It was therefore anticipated that a much more precise evaluation of dapsone compliance might be obtained by employing capsules tagged with 6 mg INH, since if the daily doses were recommended to be taken first thing each morning, the finding of a negative urine-test result would unequivocally indicate fa ilure to have taken a dose that day. This paper describes a study of dapsone compliance among out-patients in Hyderabad, India to investigate the potentialities of such an approach and to compare the acceptability of INH-marked dapsone capsules with standard dapsone tablets.…”