WHO global priority pathogens list on antibiotic resistance: an urgent need for action to integrate One Health data

Vaithinathan, Asokan Govindaraj; Vanitha, A.

doi:10.1177/1757913917743881

Cited by 84 publications

(46 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Understanding how bacterial pathogens acquire AR and how this resistance spreads and is maintained requires a One Health approach in which all ecosystems potentially involved in the process are analysed 1,2,10 . Among them, water bodies have been proposed to be relevant habitats for the origin and spread of AR 17,25 .…”

Section: Discussionmentioning

confidence: 99%

Metagenomic analysis of an urban resistome before and after wastewater treatment

Lira¹,

Vaz‐Moreira

Tamames³

et al. 2020

Sci Rep

View full text Add to dashboard Cite

Determining the effect of wastewater treatment in water resistome is a topic of interest for water quality, mainly under re-use and one-Health perspectives. the resistome, the plasmidome, and the bacterial community composition of samples from influents and treated effluents from a wastewater treatment plant located in northern portugal were studied using metagenomic techniques. Wastewater treatment contributed to reduce the abundance of resistance genes and of plasmid replicons, coinciding with a decline in the number of intrinsic resistance genes from Enterobacteriaceae, as well as with a reduction in the relative abundance of Firmicutes and Proteobacteria after treatment. these taxons comprise bacterial pathogens, including those belonging to the eSKApe group, which encompasses bacteria with the highest risk of acquiring antibiotic resistance, being the most relevant hosts of resistance genes acquired through horizontal gene transfer. our results support that wastewater treatment efficiently removes the hosts of antibiotic resistance genes and, consequently, the harboured antibiotic resistance genes. principal component analysis indicates that the resistome and the bacterial composition clustered together in influent samples, while did not cluster in final effluent samples. our results suggest that wastewater treatment mitigates the environmental dissemination of urban resistome, through the removal of the hosts harbouring mobile resistance genes. Most studies on antibiotic resistance have concentrated their efforts on human pathogens and in human-linked environments (hospitals, human hosts,…). However, the full understanding of the origin, evolution, spread, and maintenance of antibiotic resistance (AR) requires an integrative approach in which all ecosystems that may contribute to such evolution are studied; a One Health approach 1,2. One Heath is a concept derived from the idea proposed by Rudolph Virchow in the 19th Century, stating that "between animal and human medicine there are no dividing lines-nor should there be". The idea behind is that, at least in the case of infectious diseases, different ecosystems, not just the human host, may contribute to the spread of the infective agents. This is particularly relevant in the case of AR, since it is generally accepted that antibiotic resistance genes (ARGs), currently present in human pathogens, are originated in environmental organisms and, therefore, natural ecosystems can be reservoirs and participate in the spread of AR 3-9. Consequently, it has been proposed that AR is the quintessential One Health issue 2 , and that studies, integrating all habitats potentially involved in the evolution and spread of AR are needed 1,10,11. Indeed, seminal work showed that animal farms could be a reservoir of AR 12. As a consequence, the use of antibiotics in farming, for non-therapeutic or prophylactic procedures (as animal fattening), has been banned in different countries 13,14. More recently, non-clinical environments (natural and man-made ecosystems) have been pro...

show abstract

Section: Discussionmentioning

confidence: 99%

Metagenomic analysis of an urban resistome before and after wastewater treatment

Lira¹,

Vaz‐Moreira

Tamames³

et al. 2020

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Moreover, in recent years, methicillin-resistance S. aureus (MRSA) is attracting extensive attention. It usually showed multiple antimicrobial resistance and listed as one of 12 families of bacteria that pose the greatest threat to human health by WHO in 2017 (Govindaraj and Vanitha, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Staphylococcus aureus Isolated From Retail Meat and Meat Products in China: Incidence, Antibiotic Resistance and Genetic Diversity

Wu¹,

Huang²,

Wu³

et al. 2018

Front. Microbiol.

149

107

View full text Add to dashboard Cite

This study was to estimate the prevalence and characteristics of Staphylococcus aureus from 1,850 retail meat and meat products in China during July 2011 to June 2016. The samples were collected covering most provincial capitals in China, including 604 raw meat, 601 quick-frozen meat, and 645 ready-to-eat meat. Using the qualitative and quantitative methods, all 39 cities had S. aureus-positive samples, and S. aureus was detected in 35.0% (647/1,850) of the samples. The levels of S. aureus in retail meat showed that the MPN value of the majority of the positive samples ranged from 0.3 to 100 MPN/g. Twenty-four antibiotics were used to test all 868 S. aureus isolates for antibiotic susceptibility. Only 11 isolates (1.26%) were susceptible to all antibiotics, whereas most isolates (821/868, 94.6%) showed resistance or intermediary resistance to more than three or more antibiotics. Of these strains, 104 (12.0%) were resistant to more than 10 antibiotics. However, the most frequent resistance was observed to ampicillin (85.4%), followed by penicillin (84.6%), erythromycin (52.7%), tetracycline (49.3%), kanamycin (45.3%), telithromycin (30.1%), clindamycin (29.6%), streptomycin (21.1%), norfloxacin (20.4%), gentamicin (19.4%), fusidic acid (18.4%), ciprofloxacin (16.9%), chloramphenicol (13.1%), amoxycillin/clavulanic acid (11.0%), and others (<10%). 7.4% of isolates (62/868) were confirmed as methicillin-resistance S. aureus (MRSA). By molecular typing analysis, there were 164 spa types and 111 STs were identified, including 15 novel spa types and 65 newly STs by multilocus sequence typing (MLST) and spa typing. Despite the wide genetic diversity observed among the 868 isolates, a great proportion of the population belonged to finite number of major clones: ST1-t127 (93/868, 10.7%) and ST7-t091 (92/868, 10.6%), ST5-t002 (42/868, 4.8%), ST398-t034 (40/868, 4.6%), ST188-t034 (38/868, 4.4%), ST59-t437 (30/868, 3.5%), ST6-t701 (29/868, 3.3%), and ST9-t899 (27/868, 3.1%) in China. This study reflects S. aureus was readily detected in Chinese retail meat and meat products but the level were not very excessive. In this study, the high antibiotic resistance is alarming and raising public health concern. In additions, most of molecular types of isolates have been linked to human infections around the world, indicating that these types of S. aureus in China have a theoretical pathogenic potential.

show abstract

“…The development of drug resistance and detrimental side effects of the administered antibiotics are of serious concern in the treatment of H. pylori eradication. Clarithromycin-resistant H. pylori has been categorized by the World Health Organization as a "high priority" for research and development of new antibiotics (41). A novel anti-H. pylori agent should (i) show effective antibacterial action against both standard and clinical drug-resistant H. pylori strains, (ii) exert potent and selective anti-H. pylori activity and no effect on the gut microbiota, (iii) not induce the development of drug resistance, and (iv) possess wide safety.…”

Section: Discussionmentioning

confidence: 99%

In Vitro and In Vivo Activities of Zinc Linolenate, a Selective Antibacterial Agent against Helicobacter pylori

Huang

Hang

Jiang

et al. 2019

Antimicrob Agents Chemother

View full text Add to dashboard Cite

Helicobacter pylori is a major global pathogen, and its infection represents a key factor in the etiology of various gastric diseases, including gastritis, peptic ulcers, and gastric carcinoma. The efficacy of current standard treatment for H. pylori infection including two broad-spectrum antibiotics is compromised by toxicity toward the gut microbiota and the development of drug resistance, which will likely only be resolved through novel and selective antibacterial strategies. Here, we synthesized a small molecule, zinc linolenate (ZnLla), and investigated its therapeutic potential for the treatment of H. pylori infection. ZnLla showed effective antibacterial activity against standard strains and drug-resistant clinical isolates of H. pylori in vitro with no development of resistance during continuous serial passaging. The mechanisms of ZnLla action against H. pylori involved the disruption of bacterial cell membranes and generation of reactive oxygen species. In mouse models of multidrugresistant H. pylori infection, ZnLla showed in vivo killing efficacy comparable and superior to the triple therapy approach when use as a monotherapy and a combined therapy with omeprazole, respectively. Moreover, ZnLla treatment induces negligible toxicity against normal tissues and causes minimal effects on both the diversity and composition of the murine gut microbiota. Thus, the high degree of selectivity of ZnLla for H. pylori provides an attractive candidate for novel targeted anti-H. pylori treatment.

show abstract

WHO global priority pathogens list on antibiotic resistance: an urgent need for action to integrate One Health data

Cited by 84 publications

References 7 publications

Metagenomic analysis of an urban resistome before and after wastewater treatment

Metagenomic analysis of an urban resistome before and after wastewater treatment

Staphylococcus aureus Isolated From Retail Meat and Meat Products in China: Incidence, Antibiotic Resistance and Genetic Diversity

In Vitro and In Vivo Activities of Zinc Linolenate, a Selective Antibacterial Agent against Helicobacter pylori

Contact Info

Product

Resources

About