WHO Global Antimicrobial Resistance Surveillance System early implementation 2016–17

Tornimbene, Barbara; Eremin, Sergey; Escher, Martina; Griskeviciene, Jolanta; Manglani, Sapna; Pessoa-Silva, Carmen Lúcia

doi:10.1016/s1473-3099(18)30060-4

Cited by 87 publications

(72 citation statements)

References 3 publications

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“…Other datasets offer the future promise of evaluating the potential impact of climate on antibiotic resistance on a global scale. 5,19 While we have a limited understanding of the transmission networks that give rise to the spread of antibiotic resistant organisms and mechanisms of resistance, there is a general understanding that this is a complex process, connecting agriculture, animals, humans, and the broader environment. 20 Temperature plays an important role in many of these settings, and there are a number of potential mechanisms that could support a biological effect of temperature on antibiotic resistance distribution and transmission.…”

Section: Discussionmentioning

confidence: 99%

“…3,4 To combat this crisis, numerous national and international bodies have begun to develop policy and fund research aimed at identifying and targeting drivers of resistance. 3,5 However, we have an incomplete understanding of the factors beyond antibiotic consumption that influence the distribution and spread of antibiotic resistance in human populations.…”

Section: Introductionmentioning

confidence: 99%

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Rates of increase of antibiotic resistance and ambient temperature in Europe: a cross-national analysis of 28 countries between 2000-2016

McGough

MacFadden

Hattab

et al. 2018

Preprint

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Background. Widely recognized as a major public health threat globally, the rapid increase of antibiotic resistance in bacteria could soon render our most effective method to combat infections obsolete. Factors influencing the burden of resistance in human populations remain poorly described, though temperature is known to play an important role in mechanisms at the bacterial level. Methods. We performed an ecologic analysis of country level antibiotic resistance prevalence in 3 common bacterial pathogens across 28 countries in Europe, and used multivariable models to evaluate associations with minimum temperature and other predictors over a 17-year period (2000-2016). We quantified the effects of minimum temperature, population density, and antibiotic consumption on the rate of change of antibiotic resistance across geographies. Findings. For three common bacterial pathogens and four classes of antibiotics, we found evidence of a long-term effect of ambient minimum temperature on rates of increase of antibiotic resistance across 28 countries in Europe between 2000-2016. Specifically, we show that across all antibiotic classes for the pathogens E. coli and K. pneumoniae, European countries with 10°C warmer ambient temperatures have experienced more rapid increases in antibiotic resistance over the 17-year period, ranging between 0.33%/year (95% CI 0.2, 0.5) and 1.2%/year (0.4, 1.9), even after accounting for recognized drivers of resistance including antibiotic consumption and population density. We found a decreasing relationship for S. aureus and methicillin of -0.4%/year (95% CI -0.7, 0.0), reflecting widespread declines in MRSA across Europe over the study period. Interpretation. Ambient temperature may be an important modulator of the rate of change of antibiotic resistance. Our findings suggest that rising temperatures globally may hasten the spread of resistance and complicate efforts to mitigate it. Funding. Canadian Institutes of Health Research Fellowship (D.R.M.). Research in context:Evidence before this study While multiple studies have independently pointed out associations between temperature and bacterial biological cycles, few studies have focused on characterizing the relationship of ambient temperature and antibiotic resistance on a multi-geography or multi-country scale. We performed a general search on MEDLINE using the joint keywords "antibiotic resistance" and "climate" for original research published up to June 22, 2018. A recent study conducted in the US identified that locations with warmer ambient temperatures experienced higher values of antibiotic resistance prevalence using three years of data, and one European country-level analysis discovered that higher distance from the equator was a predictor for lower risk of Acinetobacter spp. resistance to carbapenems.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Rates of increase of antibiotic resistance and ambient temperature in Europe: a cross-national analysis of 28 countries between 2000-2016

McGough

MacFadden

Hattab

et al. 2018

Preprint

View full text Add to dashboard Cite

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“…After 24 h, the tested compounds, diluted in complete Dulbecco's modified Eagle's medium (DMEM), were added to each well. Cells were treated with a range of different concentrations of drug (1,5,10,20, 50, 100 μM) for 24 h at 37°C and 5 % carbon dioxide. For the untreated sample, media were used to make up equal volumes.…”

Section: Chemistrymentioning

confidence: 99%

“…Therefore, there is an imperative requirement to establish new antimicrobial agents with potent activity against resistant microorganisms. [5] Coumarin is a versatile scaffold that is widely distributed in nature with vast application in the field of medicinal chemistry. The synthetic accessibility of the coumarin scaffold enables it to become the perfect platform for structural modifications and derivatization.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Cytotoxicity and Antimicrobial Evaluation of New Coumarin‐Tagged β‐Lactam Triazole Hybrid

Dhawan

Awolade

Kisten

et al. 2020

Chemistry & Biodiversity

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A series of coumarin-tagged β-lactam triazole hybrids (10a -10o) were synthesized and tested for their cytotoxic activity against MDA-MB-231 (triple negative breast cancer), MCF-7 (estrogen receptor positive breast cancer (ER +)) and A549 (human lung carcinoma) cancer cell lines including one normal cell line, HEK-293 (human embryonic kidney). Two compounds 10b and 10d exhibited substantial cytotoxic effect against MCF-7 cancer cell lines with IC 50 values of 53.55 and 58.62 μM, respectively. More importantly, compounds 10b and 10d were non-cytotoxic against HEK-293 cell lines. Structure-activity relationship (SAR) studies suggested that the nitro and chloro group at the C-3 position of phenyl ring are favorable for anticancer activity, particularly against MCF-7 cell lines. Furthermore, antimicrobial evaluation of these compounds revealed modest inhibition of examined pathogenic strains with compounds 10c and 10i being the most promising antimicrobial agents against Pseudomonas aeruginosa and Candida albicans, respectively.

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“…The expansion of the antimicrobial drugs cannot meet the demand because of fast resistance development of microorganisms, so life span of antibiotics is shorter than expected. It has been reported in Global Antimicrobial Resistance Surveillance System (GLASS) Report published by World Health Organization (WHO) that the antibiotics used in therapy have become ineffective against bacteria over time . Nowadays, the incidence of multidrug resistance in Gram‐positive bacterial pathogens is one of the most important problems encountered in studies related to the discovery of new and more effective antibacterial agents .…”

Section: Introductionmentioning

confidence: 99%

Design and evaluation of biological activities of 1,3‐oxazolidinone derivatives bearing amide, sulfonamide, and thiourea moieties

Karaman

Zainel

Kapkac

et al. 2018

Archiv der Pharmazie

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1,3-Oxazolidine-2-one is an important heterocyclic ring participating in the chemical structure of many drugs. In this research, 22 new amide/sulfonamide/thiourea derivatives (1-22) were obtained by the reaction of (S)-4-(4-aminobenzyl)-2(1H)-1,3-oxazolidinone with 4-substituted benzoyl chlorides, 4-substituted benzene sulfonyl chlorides, and 4-substituted phenyl isothiocyanates. The structures of all synthesized compounds were clarified by FT-IR, NMR, and mass spectroscopic and elemental analysis techniques. The synthesized compounds were screened for their antimicrobial activity. Antimicrobial susceptibility and cellular physiology were evaluated using the microbroth dilution assay and the flow cytometry method. As a result, it was determined that compound 16 displayed better antimicrobial activity than chloramphenicol against Gram-positive bacteria, especially Staphylococcus aureus. In order to understand the mechanism of effect of the compounds on the cell membrane, fluorescence microscopy was used. Cell membrane damage of the Gram positive bacteria treated with compound 16 was observed as a result of intense staining with propidium iodide. In addition, genotoxicity, cytotoxicity, and absorption, distribution, metabolism, and excretion (ADME) parameters of compound 16 were examined and it was found as non-mutagenic and non-cytotoxic at the concentration at which it showed antimicrobial activity. According to the calculated ADME parameters and drug likeness scores, the compounds can be good drug candidates, especially compound 16.

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WHO Global Antimicrobial Resistance Surveillance System early implementation 2016–17

Cited by 87 publications

References 3 publications

Rates of increase of antibiotic resistance and ambient temperature in Europe: a cross-national analysis of 28 countries between 2000-2016

Rates of increase of antibiotic resistance and ambient temperature in Europe: a cross-national analysis of 28 countries between 2000-2016

Synthesis, Cytotoxicity and Antimicrobial Evaluation of New Coumarin‐Tagged β‐Lactam Triazole Hybrid

Design and evaluation of biological activities of 1,3‐oxazolidinone derivatives bearing amide, sulfonamide, and thiourea moieties

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