Who Benefits the Most From Different Psychological Chronic Pain Treatments? An Exploratory Analysis of Treatment Moderators

Jensen, Mark P.; Ehde, Dawn M.; Hakimian, Shahin; Pettet, Mark W.; Day, Melissa A.; Ciol, Márcia A.

doi:10.1016/j.jpain.2023.06.011

Cited by 3 publications

(2 citation statements)

References 78 publications

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“…These data complement previous systematic reviews and meta-analyses showing the clear efficacy of verbal suggestion in the induction of nocebo responses (Petersen et al, 2014;Rooney et al, 2023;Webster et al, 2016) but bridge a gap in the literature by illustrating the significant moderating influence of trait responsiveness to suggestion on nocebo responding. This aligns with a wealth of data showing that trait suggestibility is a reliable predictor of responses to suggestion-based interventions (Jensen et al, 2023;Milling et al, 2021; but also seems to function as a risk factor for conditions and symptoms adjacent to nocebo responding including functional neurological disorder , mass psychogenic illness (Sapkota et al, 2020) and symptoms associated with environmental factors (idiopathic environmental intolerance) .…”

Section: Discussionsupporting

confidence: 81%

Trait responsiveness to verbal suggestions predicts nocebo responding: A meta-analysis

Stein,

Heller,

Chapman

et al. 2023

Preprint

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Nocebo responding involves the experience of adverse health outcomes in response to contextual cues. These deleterious responses impact numerous features of mental and physical health but are characterized by pronounced heterogeneity. Suggestion is widely recognised as a contributing factor to nocebo responding but the moderating role of trait responsiveness to verbal suggestions (suggestibility) in nocebo responding remains poorly understood. We conducted a pre-registered meta-analysis (PROSPERO registration number CRD42023425605) to quantitatively synthesize available research on the relationship between suggestibility and nocebo responding. Four electronic databases were searched for original studies involving both the assessment of suggestibility and symptom reports in response to an inactive stimulus. Of 7,729 search results, 10 articles presenting 13 correlations between suggestibility and nocebo responding were analysed. A random-effects meta-analysis revealed a significant, albeit weak, positive correlation,r=0.21 [0.04, 0.37], between suggestibility and nocebo responses, such that more highly suggestible individuals displayed larger responses. Sensitivity and meta-regression analyses demonstrated that studies of higher methodological quality, including those that maintained experimenter blinding, exhibited stronger effect sizes. These results corroborate proposals that trait responsiveness to verbal suggestions confers greater response to nocebos and warrants renewed attention to the role of suggestibility in symptom induction and perception.For the purposes of open access, the author has applied a Creative Commons Attribution (CC BY) license to any Accepted Author manuscript version arising from this submission.

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Section: Discussionsupporting

confidence: 81%

Trait responsiveness to verbal suggestions predicts nocebo responding: A meta-analysis

Stein,

Heller,

Chapman

et al. 2023

Preprint

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“…Finally, we recently conducted a series of planned secondary analyses to identify possible moderators of the effects of four different psychological treatments for chronic pain using data from a clinical trial that had a large sample (N = 173) [ 46 ]. The treatment conditions examined were: (1) four sessions of cognitive therapy (CT), (2) hypnosis focused on pain reduction (HYP), (3) hypnosis focused on changing maladaptive pain-related thoughts (HYP-CT), and (4) a pain education control condition (ED).…”

Section: Resultsmentioning

confidence: 99%

The Role of Electroencephalogram-Assessed Bandwidth Power in Response to Hypnotic Analgesia

Jensen,

Barrett

2024

Brain Sciences

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Research supports the efficacy of therapeutic hypnosis for reducing acute and chronic pain. However, little is known about the mechanisms underlying these effects. This paper provides a review of the evidence regarding the role that electroencephalogram-assessed bandwidth power has in identifying who might benefit the most from hypnotic analgesia and how these effects occur. Findings are discussed in terms of the slow wave hypothesis, which posits that brain activity in slower bandwidths (e.g., theta and alpha) can facilitate hypnosis responsivity. Although the extant research is limited by small sample sizes, the findings from this research are generally consistent with the slow wave hypothesis. More research, including and especially studies with larger sample sizes, is needed to confirm these preliminary positive findings.

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Optimizing Pain Intensity Assessment in Clinical Trials: How Many Ratings are Needed to Best Balance the Need for Validity and to Minimize Assessment Burden?

de la Vega,

Sakulsriprasert,

Miró

et al. 2024

The Journal of Pain

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Who Benefits the Most From Different Psychological Chronic Pain Treatments? An Exploratory Analysis of Treatment Moderators

Cited by 3 publications

References 78 publications

Trait responsiveness to verbal suggestions predicts nocebo responding: A meta-analysis

Trait responsiveness to verbal suggestions predicts nocebo responding: A meta-analysis

The Role of Electroencephalogram-Assessed Bandwidth Power in Response to Hypnotic Analgesia

Optimizing Pain Intensity Assessment in Clinical Trials: How Many Ratings are Needed to Best Balance the Need for Validity and to Minimize Assessment Burden?

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