Whither living donor liver transplantation?

Strong, Russell W.

doi:10.1002/lt.500050613

Cited by 100 publications

(50 citation statements)

References 18 publications

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“…24,35 Although the precise number of donor deaths to date may be speculative, 35 at least 2 deaths from pulmonary embolus, both in women with a history of smoking, occurred in pediatric living liver transplant donors. One death from intraabdominal sepsis and poor graft function was reported in a right-lobe graft donor (J.H.…”

Section: Ldlt Donor Mortalitymentioning

confidence: 99%

Long-term complications of living donor liver transplantation

Renz¹,

Roberts²

2000

Liver Transpl

135

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Key Points 1. Donor outcome after living donor liver transplantation (LDLT) is related to type of liver resection. Left lateral segmentectomy is used in pediatric cases and right lobectomy is used in adult cases. 2. Biliary complications occur in 5% to 10% of both pediatric and adult cases. 3. Three donors, 2 in pediatric LDLT and 1 in adult LDLT, have died. Estimated mortality is 0.13% for pediatric donation and 0.2% for adult donation. 4. Postoperative cholestasis occurs commonly in donors, but clinically relevant jaundice occurs in less than 5%. 5. Other donor morbidity may be related to incisional hernias, postoperative gastric dysfunction, and pain. 6. Donors report overall satisfaction with LDLT, and 88% believed that the role of LDLT should be increased. 7. All donors returned to predonation activities; 25% by 1 month, 75% by 3 months, 88% by 6 months, and 100% by 1 year. (Liver Transpl 2000;6:S73-S76.)

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Section: Ldlt Donor Mortalitymentioning

confidence: 99%

Long-term complications of living donor liver transplantation

Renz¹,

Roberts²

2000

Liver Transpl

135

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“…Although there has been a proliferation of programs performing living donor liver transplantation (LDLT), the balance between risk and benefit to both donor and recipient in the setting of retransplantation is undefined. With reported donor morbidity in the range of 3% to 17% and donor mortality at approximately 0.5%, 17,18 one needs to carefully consider application of LDLT to the patient who has undergone retransplantation. Technical issues unique to retransplantation, such as complicated hilar dissection, thrombosed vessels, use of vascular grafts, and bile duct reconstruction, may further diminish outcome after LDLT.…”

Section: S44mentioning

confidence: 99%

Retransplantation for hepatitis C: Implications of different policies

Rosen¹

2000

Liver Transpl

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“…In a provocative editorial, Russell Strong, who successfully performed the first adult-to-child live donor liver transplantation using the left lateral segment, cautioned the use of the right lobe, which is often required in ALDLT. 7 His view was corroborated by the Chicago Group, which methodically developed one of the first pediatric programs. 8 While the transplant community reckons that donor safety comes first, 9-11 the donor procedure in ALDLT has an estimated mortality of 0.5%.…”

mentioning

confidence: 98%

Donor quality of life before and after adult-to-adult right liver live donor liver transplantation

Chan

Liu

et al. 2006

Liver Transpl

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Donor right hepatectomy for adult-to-adult live donor liver transplantation (ALDLT) is a major surgical operation for the benefit of the recipient. Justification of procedure mandates knowledge of the possible physical and psychological negative effects on the donor. We prospectively and longitudinally quantified donor quality of life using generic and condition-specific questionnaires up to 1 year. The generic questionnaires were the Karnofsky Performance Status scale and the Chinese (Hong Kong) version of the Medical Outcomes Study 36-Item Short-Form Survey, which measures 8 health concepts: 4 physical components and 4 mental components. Within 1 year, 30 consecutive donors were included. These 11 male and 19 female donors (36.7% and 63.3%, respectively) had a median age of 35 years (range, 21-56 years). There was no donor mortality or major complications. Donor quality-of-life worsening was most significant in the first 3 postoperative months, particularly among the physical components. The physical and mental components returned to the previous levels in 6 to 12 months' time, though the Karnofsky performance scores were slightly lower at 1 year (P ϭ 0.011). Twenty-six (86.7%) donors declared that they would donate again if there were such a need and it were technically possible. It was noticed that older donors were more likely to express unwillingness to donate again. In conclusion, the temporary worsening of donor quality of life substantiates ALDLT as an acceptable treatment modality. Liver Transpl 12: 1529-1536, 2006.

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Whither living donor liver transplantation?

Cited by 100 publications

References 18 publications

Long-term complications of living donor liver transplantation

Long-term complications of living donor liver transplantation

Retransplantation for hepatitis C: Implications of different policies

Donor quality of life before and after adult-to-adult right liver live donor liver transplantation

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