Whithania somnifera (herbal extract) inhibits cellular store-operated Ca2+ entry in patients with type 2 diabetes

Balasubramanyam, Muthuswamy; Venkateswaran, Ajay; Mohan, V.

doi:10.1016/s0168-8227(00)81286-3

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“…Hence, it is of interest to evaluate the actions of W somnifera on the immune system. 7 Tumor growth has been reported to induce various phenotypic and functional changes in the cellular constituents of the host immune system. These changes have been implicated as mechanisms by which tumors subvert potential beneficial host responses.…”

Section: Introductionmentioning

confidence: 99%

Immunomodulatory activity in tumor-bearing mice treated with Withania somnifera extract

Melo¹,

Melo²,

Marcucci³

et al. 2021

JAPLR

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We investigated some actions of Withania somnifera on the growth and differentiation of hematopoietic precursors [granulocyte/macrophage colony cell formation (CFU-GM)] of normal animals and EAT bearers, which were treated with different doses (20, 50, or 100 mg/kg/day). We also evaluated the presence of colony stimulatory factors in the animal's serum, as well as its survival. Furthermore, we analyzed lymphocyte proliferation, IFN-ɤ, and TNF-α concentrations in treated bearing mice. Our results demonstrated Withania somnifera effectiveness on hematopoietic precursors growth and differentiation in marrow and spleen TAE-bearing mice. As it was already expected, EAT produced myelosuppression and increased CFU-GM spleen number concomitantly. The treatment of EAT-bearing animals with W.S. (20, 50, and 100 mg/Kg) produced a dose-dependent increase in myelopoiesis, an increase in a lifetime, and a reduction in spleen colony number. All this happened parallel to survival. As to lymphocyte proliferation, they were also dose-dependent in treated bearing animals. Concerning IFN-γ levels, we observed a significant reduction in non-treated bearing mice. Levels of TNF-α of treated bearing mice significantly increased when compared to the non-treated bearing group. These results are encouraging since they favor the use of W.S. extract in therapeutic combinations with other chemotherapeutic agents to reduce myelotoxicity and supplement the tumoricidal efficacy of this plant.

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Section: Introductionmentioning

confidence: 99%