White Tea extract induces lipolytic activity and inhibits adipogenesis in human subcutaneous (pre)-adipocytes

Söhle, Jörn; Knott, Anja; Holtzmann, Ursula; Siegner, Ralf; Grönniger, Elke; Schepky, Andreas; Gallinat, Stefan; Wenck, Horst; Stäb, Franz; Winnefeld, Marc

doi:10.1186/1743-7075-6-20

Cited by 72 publications

(58 citation statements)

References 25 publications

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“…As other researches have shown the green tea extract is an effective adjunct to reduce LDL andit is well tolerated [16], the results of the current study demonstrated highly significant (p<0.01) hypolypidemic effect in treated groups compared to the control group, while its level was significantly improved in GT+ rifampin treated rats compared to the rifampin group. Our results showed that the effect of WT on blood lipid profile was more efficient than green tea in dose dependent manner.…”

Section: Discussionsupporting

confidence: 57%

“…The Toxic effects of rifampicin on animals and plants are well documented [1]. Based on these data, green and white tea extracts were tested in this study for their effects on rifampin induced hepatic injuries in male rats through assessment of lipid profile, liver enzyme and antioxidant capacity [16].…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, the concentrations of epigallocatechin-3-gallate (EGCG) cathenin, antioxidant activity and also methylxanthines (like caffeine) in WT are more thanGreen or Black Tea [16,17].…”

Section: Introductionmentioning

confidence: 99%

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A Preliminary Study of Comparison of Preventive and Therapeutic Effect of Green and White Tea Against Rifampicin-Induced Chronic Hepatotoxicity in Rats

Serki¹

2017

AJCEM

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Abstract:Many different dietary supplements are currently marked for the management of hepatic illness, but the evidence for effectiveness is mixed. The aim of this study was to evaluate the effect of white and green tea extracts in a rifampicininduced hepatic damage model of rats. In this study 55 male wistar albino rats were divided into 11 groups of 5 animal, named: normal control, hepatotoxic control with rifampicin (150 mg/kg), hepatotoxic with silymarin, hepatotoxic treated with green tea (250 and 500 mg/kg aqueous extract), hepatotoxic treated with white tea (250 and 500 mg/kg aqueous extract) and preventive groups of green and white tea with mentioned above doses. After 3 weeks treatment with green and white tea, a significant reduction in total cholesterol, triglyceride, LDL cholesterol, malondialdehyde and liver enzymes was observed. In the cases of white tea these changes was notable and dose-dependently improved liver function compared with green tea. The results obtained in this study suggest white tea is much more effective than green tea for prevention and treatment of druginduced liver injury.

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Section: Discussionsupporting

confidence: 57%

Section: Discussionmentioning

confidence: 99%

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A Preliminary Study of Comparison of Preventive and Therapeutic Effect of Green and White Tea Against Rifampicin-Induced Chronic Hepatotoxicity in Rats

Serki¹

2017

AJCEM

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“…These recent studies have also indicated that EGCG improves cholesterol metabolism through the upregulation of LDL receptor and also reduces extracellular apoB levels (38). In addition, sterol regulatory element-binding proteins-1c (SREBP-1c), C/EBP-β, and peroxisome proliferator-activated receptor-γ (PPAR-γ), also are involved in the cholesterol-lowering effect of EGCG (39,40). However, effects of EGCG on ABCA1, which plays a key role in the process of RCT, have rarely been described until now.…”

Section: Discussionmentioning

confidence: 98%

Epigallocatechin-3-gallate prevents TNF-α-induced NF-κB activation thereby upregulating ABCA1 via the Nrf2/Keap1 pathway in macrophage foam cells

et al. 2012

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Abstract. The ATP-binding membrane cassette transporter A1 (ABCA1) plays a protective role in the development of atherosclerosis for the reverse cholesterol transport process. Epigallocatechin-3-gallate (EGCG), which exists abundantly in green tea, exerts an anti-atherosclerotic effect via antiinflammatory and metabolic regulation activities. Many genes and proteins related to lipid metabolism are involved in the lowering cholesterol effects of EGCG. However, effects of EGCG on ABCA1 have rarely been described. In the study presented here, we found that exposure of macrophage foam cells to TNF-α results in a downregulation of ABCA1 and a decrease in cholesterol efflux to apoA1, which is attenuated by pretreatment with EGCG. Moreover, rather than activating the Liver X receptor (LXR) pathway, inhibition of the TNF-α-induced nuclear factor-κB (NF-κB) activity is detected with EGCG treatment in cells. In order to inhibit the NF-κB activity, EGCG can promote the dissociation of the nuclear factor E2-related factor 2 (Nrf2)-Kelch-like ECH-associated protein 1 (Keap1) complex; when the released Nrf2 translocates to the nucleus and activates the transcription of genes containing an ARE element inhibition of NF-κB occurs and Keap1 is separated from the complex to directly interact with IKKβ and thus represses NF-κB function. These results provide novel insight into the anti-inflammatory effects of EGCG, as well as the identification of a novel potential therapeutic role for the prevention of atherosclerosis.

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“…15 White tea leaves extract was reported to inhibit adipogenesis and stimulate lipolytic activity. 16 Another study also reported that white tea leaves ethanolic extract has an antidiabetic activity as inhibitor α-glucosidase, α-amylase, and dipeptidyl peptidase IV.…”

Section: Discussionmentioning

confidence: 97%

Pharmacognostic and Phytochemical Standardization of White Tea Leaf (Camellia sinensis L. Kuntze) Ethanolic Extracts

Ekayanti¹,

Ardiana²,

Najib³

et al. 2017

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Background: Tea or also known as Camellia sinensis (Theaceae family) is the most popular plant and beverage in the world because of the sensory properties, prices are relatively cheap, stimulant effects, and their potential health benefits but white tea is not widely known. White tea is made from unfermented tea leaves young shoots protected from sunlight to avoid polyphenols degradation which inhibits of the chlorophyll formation and causing the white color on the leaf buds. Objective: The objective of research and development of herbal medicine is to improve the quality and safety of natural products. Materials and Methods: Macroscopical and microscopical features of the leaf have been analysis using an optical microscope and fragment analysis under scanning electron microscopy (SEM). Phytochemical and physico-chemical analysis were evaluated. The observation of the FTIR spectrum profiles is done by interpreting the typical peak that appears. Results: The leaf has actinocytic stomata, unicellular trichomes, heterogenous mesophyll which is characterized by the presence of calcium oxalate crystals and sclereid cells. Phytochemical analysis indicated resources the presence of tannins, flavonoids, glycosides and saponins.The content of polyphenol from white tea leaves ethanolic extract is 35.73% with the largest concentration of catechins is 18.84% and 17.43% tannins. The derivative content of catechins is EGCG with 7.37%. FTIR analysis showed functional groups of O-H, C-H, N-H, C=O, C=C, and C-O. Conclusion: Pharmacognostic and phytochemicals features established in this study may be used as part of the pharmacopoeial standard which can play an important role in its standardization.

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White Tea extract induces lipolytic activity and inhibits adipogenesis in human subcutaneous (pre)-adipocytes

Cited by 72 publications

References 25 publications

A Preliminary Study of Comparison of Preventive and Therapeutic Effect of Green and White Tea Against Rifampicin-Induced Chronic Hepatotoxicity in Rats

A Preliminary Study of Comparison of Preventive and Therapeutic Effect of Green and White Tea Against Rifampicin-Induced Chronic Hepatotoxicity in Rats

Epigallocatechin-3-gallate prevents TNF-α-induced NF-κB activation thereby upregulating ABCA1 via the Nrf2/Keap1 pathway in macrophage foam cells

Pharmacognostic and Phytochemical Standardization of White Tea Leaf (Camellia sinensis L. Kuntze) Ethanolic Extracts

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