White sustainable luminescent determination of nifuroxazide using nitrogen–sulphur co-doped carbon quantum dots nanosensor in bulk and various pharmaceutical matrices

Elnaggar, Mai M.; El-Yazbi, Amira F.; Belal, Tarek S.; Elbardisy, Hadil M.

doi:10.1039/d3ra05471c

RSC Adv.

2023

DOI: 10.1039/d3ra05471c

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White sustainable luminescent determination of nifuroxazide using nitrogen–sulphur co-doped carbon quantum dots nanosensor in bulk and various pharmaceutical matrices

Mai M. Elnaggar,

Amira F. El-Yazbi,

Tarek S. Belal

et al.

Abstract: Nifuroxazide (NFX) fluorimetric determination via quenching nitrogen–sulphur co-doped carbon quantum dots (NSC-dots) luminescence intensity.

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2024

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Cited by 10 publications

References 42 publications

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A new fluorescence probe for sofosbuvir analysis in dosage form and spiked human plasma

Nasr,

Talaat,

Morshedy

et al. 2024

Luminescence

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A simple, rapid, and low‐cost technique was developed to allow reliable analysis of the anti‐hepatitis C drug sofosbuvir in bulk, tablet form, and spiked human plasma. This method depends on the ability of sofosbuvir to quench the fluorescence of the newly synthesized 2‐amino‐3‐cyano‐4,6‐dimethylpyridine (reagent 3). Elemental analysis and spectral data were used to validate the structure of the synthesized reagent. The newly synthesized reagent exhibited a satisfactory level of fluorescence emission at 365 nm after excitation at 247 nm. All experimental variables that might affect the quenching process were analyzed and optimized. Linearity, range, accuracy, precision, limit of detection (LOD), and limit of quantitation (LOQ) were all validated in accordance with the International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use (ICH) guidelines. The concentration range was shown to be linear between 0.1 and 1.5 μg/mL. The technique was effectively utilized for sofosbuvir analysis in both its tablet dosage form and spiked human plasma, with mean percentage recoveries of 100.13 ± 0.35 and 94.26 ± 1.69, respectively.

show abstract

A new fluorescence probe for sofosbuvir analysis in dosage form and spiked human plasma

Nasr,

Talaat,

Morshedy

et al. 2024

Luminescence

View full text Add to dashboard Cite

show abstract

Fluorimetric determination of Vonoprazan via quenching of nitrogen and sulfur co‐doped carbon quantum dots: A rapid and sustainable analytical approach

Barseem,

Elshahawy,

Elagamy

2024

Luminescence

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In this study, an environmentally sustainable fluorimetric method for determination of Vonoprazan fumarate (VON) in dosage forms using nanoprobes consisting of nitrogen and sulfur co‐doped carbon quantum dots (N, S‐CQDs). The N, S‐CQDs were prepared through a microwave‐assisted method in 30 s. The resulting N, S‐CQDs were characterized using transmission electron microscopy (TEM), high‐resolution transmission electron microscopy (HRTEM), Fourier transform infrared spectroscopy (FTIR), and X‐ray photoelectron spectroscopy (XPS). They exhibit fluorescence emission at 460 nm after excitation at 385 nm with a high quantum yield (60%). The analytical approach for VON determination relies on the quenching effect exerted by VON on the native fluorescence intensity of CQDs. The quenching mechanism was investigated using Stern–Volmer plots. The proposed method demonstrates linearity across a concentration range 10–80 μM (4.6–36.8 μg/mL) with corresponding limits of detection and quantitation calculated as 2.17 μM (0.99 μg/mL) and 6.58 μM (3.02 μg/mL), respectively. The method has been effectively utilized for the determination of VON in the pharmaceutical samples. Statistical comparison with reported RP‐HPLC has been performed to verify the accuracy and precision of the developed method. The environmental sustainability of the developed method has been thoroughly examined through various greenness metrics.

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Alfalfa biomass as a green source for the synthesis of N,S-CDs via microwave treatment. Application as a nano sensor for nifuroxazide in formulations and gastric juice

Osman,

El-Shaheny,

Ibrahim

2024

Analytica Chimica Acta

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White sustainable luminescent determination of nifuroxazide using nitrogen–sulphur co-doped carbon quantum dots nanosensor in bulk and various pharmaceutical matrices

Abstract: Nifuroxazide (NFX) fluorimetric determination via quenching nitrogen–sulphur co-doped carbon quantum dots (NSC-dots) luminescence intensity.

Cited by 10 publications

References 42 publications

A new fluorescence probe for sofosbuvir analysis in dosage form and spiked human plasma

A new fluorescence probe for sofosbuvir analysis in dosage form and spiked human plasma

Fluorimetric determination of Vonoprazan via quenching of nitrogen and sulfur co‐doped carbon quantum dots: A rapid and sustainable analytical approach

Alfalfa biomass as a green source for the synthesis of N,S-CDs via microwave treatment. Application as a nano sensor for nifuroxazide in formulations and gastric juice

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