Needle knife papillotomy (NKP) as a freehand, operatordependent access technique is traditionally considered a high-risk procedure in more conventional endoscopic retrograde cholangiopancreatography (ERCP) indications, albeit data are accumulating to suggest a lower risk profile if used early during ERCP procedures. 1 By contrast, papillary stone impaction and the far rarer choledochoceles may represent excellent first-line indications for upfront NKP, alternatively designated "needle knife excision" in the former instance. 2 This is illustrated herein in 39-year-old patient with acute biliary-type pain, marked cholestasis, and minor systemic inflammatory parameters (Figure 1, Suppl. Video).