White mulberry fruit polysaccharides enhance endothelial nitric oxide production to relax arteries in vitro and reduce blood pressure in vivo

Wang, Chuyan; Cheng, Wenhui; Bai, Suwen; Li, Ye; Du, Juan; Zhong, Ming-Kui; Liu, Jian; Zhao, Ren; Shen, Bing

doi:10.1016/j.biopha.2019.109022

Cited by 23 publications

(16 citation statements)

References 24 publications

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“…Moreover, a study found that white mulberry fruit polysaccharides could provoke endothelium-dependent relaxation in rat mesenteric arteries and NO production in endothelial cells, and its intravenous injection induced the reduction of blood pressure in both normotensive rats and spontaneously hypertensive rats, while this effect was markedly attenuated in normotensive rats pretreated with the NO synthase inhibitor NG-nitro-L-arginine methyl ester (L-NAME). These results suggested that the hypotensive effect of white mulberry fruit was mediated by the NO pathway [ 67 ]. Additionally, grape seed polyphenol extract promoted the production of NO and reduced the blood pressure in hypertensive rats via upregulating the expression of eNOS and Sirtuin-1 [ 68 ].…”

Section: Experimental Studiesmentioning

confidence: 99%

Antioxidant Food Components for the Prevention and Treatment of Cardiovascular Diseases: Effects, Mechanisms, and Clinical Studies

Zhou

Luo

Shang

et al. 2021

Oxidative Medicine and Cellular Longevity

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Cardiovascular diseases (CVDs) have gained increasing attention because of their high prevalence and mortality worldwide. Epidemiological studies revealed that intake of fruits, vegetables, nuts, and cereals could reduce the risk of CVDs, and their antioxidants are considered as the main contributors. Moreover, experimental studies showed that some antioxidant natural products and their bioactive compounds exerted beneficial effects on the cardiovascular system, such as polyphenols, polysaccharides, anthocyanins, epigallocatechin gallate, quercetin, rutin, and puerarin. The mechanisms of action mainly included reducing blood pressure, improving lipid profile, ameliorating oxidative stress, mitigating inflammation, and regulating gut microbiota. Furthermore, clinical trials confirmed the cardiovascular-protective effect of some antioxidant natural products, such as soursop, beetroot, garlic, almond, and green tea. In this review, we summarized the effects of some antioxidant natural products and their bioactive compounds on CVDs based on the epidemiological, experimental, and clinical studies, with special attention paid to the relevant mechanisms and clinical trials.

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Section: Experimental Studiesmentioning

confidence: 99%

Antioxidant Food Components for the Prevention and Treatment of Cardiovascular Diseases: Effects, Mechanisms, and Clinical Studies

Zhou

Luo

Shang

et al. 2021

Oxidative Medicine and Cellular Longevity

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“…The effect of anti-vascular smooth muscle hyper-responsiveness of LMWF is mainly achieved by restoring the activity of antioxidant enzymes to inhibit the production of ROS, and inhibiting COX-2 to reduce the level of vasoconstrictor TXA2 in vascular smooth muscle ( Liang et al, 2016 ). Consistently, mean arterial blood pressure in both normal blood pressure rats and hypertensive rats were appreciably lowered by white mulberry fruit polysaccharides, which is also related to the increase of the release of NO in vascular endothelial cells ( Wang et al, 2019 ). In this study, the production of NO may be related to the activation of intracellular Ca 2+ signaling and PI3K/AKT signaling pathway.…”

Section: Protective Effects Of Plant Polysaccharides On Cardiovascular Systemmentioning

confidence: 87%

Cardiovascular Protective Effects of Plant Polysaccharides: A Review

Dong

Zhou

et al. 2021

Front. Pharmacol.

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Cardiovascular disease is a kind of heart, brain, and blood vessel injury disease by the interaction of various pathological factors. The pathogenesis of cardiovascular disease is complex with various risk factors, including abnormally elevated blood pressure, glucose, and lipid metabolism disorders, atherosclerosis, thrombosis, etc. Plant polysaccharides are a special class of natural products derived from plant resources, which have the characteristics of wide sources, diverse biological activities, and low toxicity or side effects. Many studies have shown that plant polysaccharides improve cardiovascular diseases through various mechanisms such as anti-oxidative stress, restoring the metabolism of biological macromolecules, regulating the apoptosis cascade to reduce cell apoptosis, and inhibiting inflammatory signal pathways to alleviate inflammation. This article reviews the pharmacological effects and protective mechanisms of some plant polysaccharides in modulating the cardiovascular system, which is beneficial for developing more effective drugs with low side effects for management of cardiovascular diseases.

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“…The NO-cyclic guanosine monophosphate (cGMP) signaling pathway is a potential therapeutic target for heart failure, and a reduction in NO bioavailability may result in the decreased production of cGMP, which could lead to decreased protection against myocardial injury, vascular and ventricular sclerosis, fibrosis, hypertrophy, and cardiorenal syndrome ( Udelson et al, 2020 ). K ATP channels can activate the L-arginine/NO/cGMP cascade pathway to induce membrane hyperpolarization, which results in shortening the action potential and restricting Ca 2+ entry through Ca 2+ channels, thus contributing to cardioprotection and vasodilatation ( Wang et al, 2019a ; Iguchi et al, 2019 ). Reductions in the arterial blood pressure effect of white mulberry fruit polysaccharides, the vascular relaxation effect of tetrahydropalmatine on rat aortae, and the vasodilatory effect of formaldehyde, either partially or completely, are all mediated by the NO/cGMP/K ATP pathway ( Wang et al, 2019a ; Zhou et al, 2019a ; Zhao et al, 2019 ).…”

Section: Regulation Of K Atp Channels By Small Act...mentioning

confidence: 99%

Functional Regulation of KATP Channels and Mutant Insight Into Clinical Therapeutic Strategies in Cardiovascular Diseases

et al. 2022

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ATP-sensitive potassium channels (KATP channels) play pivotal roles in excitable cells and link cellular metabolism with membrane excitability. The action potential converts electricity into dynamics by ion channel-mediated ion exchange to generate systole, involved in every heartbeat. Activation of the KATP channel repolarizes the membrane potential and decreases early afterdepolarization (EAD)-mediated arrhythmias. KATP channels in cardiomyocytes have less function under physiological conditions but they open during severe and prolonged anoxia due to a reduced ATP/ADP ratio, lessening cellular excitability and thus preventing action potential generation and cell contraction. Small active molecules activate and enhance the opening of the KATP channel, which induces the repolarization of the membrane and decreases the occurrence of malignant arrhythmia. Accumulated evidence indicates that mutation of KATP channels deteriorates the regulatory roles in mutation-related diseases. However, patients with mutations in KATP channels still have no efficient treatment. Hence, in this study, we describe the role of KATP channels and subunits in angiocardiopathy, summarize the mutations of the KATP channels and the functional regulation of small active molecules in KATP channels, elucidate the potential mechanisms of mutant KATP channels and provide insight into clinical therapeutic strategies.

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White mulberry fruit polysaccharides enhance endothelial nitric oxide production to relax arteries in vitro and reduce blood pressure in vivo

Cited by 23 publications

References 24 publications

Antioxidant Food Components for the Prevention and Treatment of Cardiovascular Diseases: Effects, Mechanisms, and Clinical Studies

Antioxidant Food Components for the Prevention and Treatment of Cardiovascular Diseases: Effects, Mechanisms, and Clinical Studies

Cardiovascular Protective Effects of Plant Polysaccharides: A Review

Functional Regulation of KATP Channels and Mutant Insight Into Clinical Therapeutic Strategies in Cardiovascular Diseases

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