White Matter Tract Alterations in Drug-Naïve Parkinson's Disease Patients With Excessive Daytime Sleepiness

Ashraf‐Ganjouei, Amir; Kheiri, Ghazaleh; Masoudi, Maryam; Mohajer, Bahram; Zadeh, Mahtab Mojtahed; Saberi, Pejman; Shandiz, Mehdi Shirin; Aarabi, Mohammad Hadi

doi:10.3389/fneur.2019.00378

Cited by 9 publications

(7 citation statements)

References 41 publications

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“…We have previously demonstrated using resting state functional magnetic resonance imaging (rs-fMRI) decreased activation in the left cerebellum and inferior frontal gyrus, but increased activation in the left paracentral lobule in PD patients with EDS, compared with patients without EDS (Wen et al, 2016). A recent study using diffusion tensor imaging revealed that EDS in PD was associated with decreased microstructural connectivity in the fornices, inferior longitudinal fasciculi and cerebellar peduncles (Ashraf-Ganjouei et al, 2019). To date, there has not been a study examining the intrinsic neural network connectivity that underscores EDS in PD.…”

Section: Introductionmentioning

confidence: 99%

Increased Activation of Default Mode Network in Early Parkinson’s With Excessive Daytime Sleepiness

Ooi

Wen

et al. 2019

Front. Neurosci.

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Background and Objectives: The underlying neuropathology of excessive daytime sleepiness (EDS) remains elusive in Parkinson's disease (PD). We aim to investigate neural network changes that underlie EDS in PD.Methods: Early PD patients comprising eighty-one patients without EDS (EDS−) and seventeen patients with EDS (EDS+) received a resting state functional MRI scan and the Epworth Sleepiness Scale (ESS). Connectivities within the default mode network (DMN), motor and basal ganglia networks were compared between the EDS+ and EDS− groups. Correlations between network connectivity and the severity of EDS were investigated through linear regression.Results: EDS+ patients displayed a trend of increased network connectivity of the posterior DMN (pDMN). A significant positive correlation was found between connectivity of the ventromedial prefrontal cortex in the pDMN and ESS.Conclusion: EDS+ patients are likely to display increased activation in the DMN, suggesting neural compensation in early PD or impaired attentiveness due to mechanisms such as mind-wandering.

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Section: Introductionmentioning

confidence: 99%

Increased Activation of Default Mode Network in Early Parkinson’s With Excessive Daytime Sleepiness

Ooi

Wen

et al. 2019

Front. Neurosci.

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“…The lack of correlation between EDS and disease severity of PD [Hoehn & Yahr stage (H&Y)] has led to the notion that the EDS might be associated with PD-specific pathology (Yousaf et al, 2018b). However, in vivo neuroimaging quantification has been used to detect early pathophysiological changes in PD with EDS (PD-EDS), potentially serving as a biomarker for disease progression and treatment monitoring (Chondrogiorgi et al, 2016;Wen et al, 2017;Ashraf-Ganjouei et al, 2019). Molecular imaging studies using positron emission tomography (PET) and single-photon emission computed tomography (SPECT) implicate EDS with dopaminergic dysfunction in subcortical regions (Happe et al, 2007;Pagano et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Striatum Shape Hypertrophy in Early Stage Parkinson’s Disease With Excessive Daytime Sleepiness

Gong

Yang

et al. 2020

Front. Neurosci.

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Introduction: Excessive daytime sleepiness (EDS) is one of the common and burdensome non-motor symptoms of Parkinson's disease (PD). However, the underlying neuropathology mechanism in PD patients with EDS (PD-EDS) remains unclear. The present study aims to delineate potential locations of structural alteration of subcortical regions in early stage and drug-naïve PD-EDS. Methods: The study had 252 patients with PD and 92 matched healthy controls (HC). EDS was estimated with the Epworth Sleepiness Scale, with a cutoff of 10. Ultimately, 59 patients were considered as PD-EDS. The remaining 193 were PD patients without EDS (PD-nEDS). FMRIB's Integrated Registration and Segmentation Tool (FIRST) was employed to assess the volumetric and surface alterations of subcortical nuclei in PD and PD-EDS. Results: Volumetric analyses found no difference in the subcortical nucleus volume between PD and HC, or PD-EDS and PD-nEDS groups. The shape analyses revealed the local atrophic changes in bilateral caudate and right putamen in patients with PD. In addition, the hypertrophic changes were located in the right putamen and left pallidum in PD-EDS than in PD-nEDS. Conclusion: Our findings revealed the regional hypertrophy of the striatum in PD-EDS. Our results indicate that local hypertrophic striatum would be a valuable early biomarker for detecting the alteration in PD-EDS. The shape analysis contributes valuable information when investigating PD-EDS.

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“…Levodopa‐equivalent dose was the only predictor of EDS development, whereas the dopamine‐agonist dose was the only predictor of EDS severity . On the other hand, very recently, microstructural abnormalities in drug‐naive PD patients with EDS involving the fornix, inferior longitudinal fasciculus, and inferior and middle cerebellar peduncles have been found, suggesting that EDS also could occur in the early stage of PD and without the influence of dopaminergic therapy . Accordingly, using resting‐state fMRI, Wen and colleagues showed widespread abnormalities in functional connectivity in drug‐naive PD patients with EDS compared with patients without, suggesting the presence of neural downregulation and compensatory mechanisms even at an early stage of disease.…”

Section: Resultsmentioning

confidence: 99%

MRI of Motor and Nonmotor Therapy‐Induced Complications in Parkinson's Disease

2020

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Levodopa therapy remains the most effective drug for the treatment of Parkinson's disease, and it is associated with the greatest improvement in motor function as assessed by the Unified Parkinson's Disease Rating Scale. Dopamine agonists have also proven their efficacy as monotherapy in early Parkinson's disease but also as adjunct therapy. However, the chronic use of dopaminergic therapy is associated with disabling motor and nonmotor side effects and complications, among which levodopa‐induced dyskinesias and impulse control behaviors are the most common. The underlying mechanisms of these disorders are not fully understood. In the last decade, classic neuroimaging methods and more sophisticated techniques, such as analysis of gray‐matter structural imaging and functional magnetic resonance imaging, have given access to anatomical and functional abnormalities, respectively, in the brain. This review presents an overview of structural and functional brain changes associated with motor and nonmotor therapy‐induced complications in Parkinson's disease. Magnetic resonance imaging may offer structural and/or functional neuroimaging biomarkers that could be used as predictive signs of development, maintenance, and progression of these complications. Neurophysiological tools, such as theta burst stimulation and transcranial magnetic stimulation, might help us to integrate neuroimaging findings and clinical features and could be used as therapeutic options, translating neuroimaging data into clinical practice. © 2020 International Parkinson and Movement Disorder Society

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White Matter Tract Alterations in Drug-Naïve Parkinson's Disease Patients With Excessive Daytime Sleepiness

Cited by 9 publications

References 41 publications

Increased Activation of Default Mode Network in Early Parkinson’s With Excessive Daytime Sleepiness

Increased Activation of Default Mode Network in Early Parkinson’s With Excessive Daytime Sleepiness

Striatum Shape Hypertrophy in Early Stage Parkinson’s Disease With Excessive Daytime Sleepiness

MRI of Motor and Nonmotor Therapy‐Induced Complications in Parkinson's Disease

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