White matter structural network disturbances in first-episode, drug-naïve adolescents with generalized anxiety disorder

Yang, Fan; Zhang, Jinbo; Fan, Linlin; Liao, Mei; Wang, Yuyin; Chen, Chang; Zhai, Tianyi; Zhang, Yan; Li, Lingjiang; Su, Linyan; Dai, Zhengjia

doi:10.1016/j.jpsychires.2020.08.004

Cited by 9 publications

(4 citation statements)

References 93 publications

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“…Similar alterations in AN could explain psychiatric comorbidities of the illness. Notably, node/subnetwork-based analyses of OCD, major depressive disorder, and anxiety disorders have not identified differences between patient and HC populations that match those reported in this study (e.g., (60)(61)(62)).…”

Section: Discussionsupporting

confidence: 53%

Large-Scale Exploration of Whole-Brain Structural Connectivity in Anorexia Nervosa: Alterations in the Connectivity of Frontal and Subcortical Networks

Lloyd

Foerde

Muratore

et al. 2023

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

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Section: Discussionsupporting

confidence: 53%

Large-Scale Exploration of Whole-Brain Structural Connectivity in Anorexia Nervosa: Alterations in the Connectivity of Frontal and Subcortical Networks

Lloyd

Foerde

Muratore

et al. 2023

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

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“…For instance, occipital cortical 5-HT2A receptor down-regulation relating to an hyperactive serotonergic system has been found in dogs with anxiety disorders 6 . Of interest compared with healthy controls, Yang et al 14 found decreased nodal degree in the occipital brain areas of structural connectome in (human) patients with generalized anxiety disorder, which demonstrated stronger sensitivity and over-processing of emotional visual information. Moreover, Lai 78 suggested that the connectivity between occipital lobe and other brain regions could be impaired due to excessive anxiety and fear, which is also consistent with our findings of decreased nodal degree in the occipital lobe in anxious dogs.…”

Section: Discussionmentioning

confidence: 99%

“…Diffusion tensor imaging (DTI) is an non-invasive technique that measures the diffusion of water molecules in tissues, and provides useful information about microstructure of brain white matter (WM) in vivo 12 . It has been widely used for studying brain structural connectivity in human populations, as well as in psychiatric and neurological diseases that are characterized by WM deficits, such as depression 13 , anxiety disorders 14 , and Alzheimer’s disease 15 . Furthermore, graph theoretical approaches have been widely applied to connectome studies to investigate the topological organization alterations in neuropsychiatric disorders (e.g.…”

mentioning

confidence: 99%

Structural connectome alterations in anxious dogs: a DTI-based study

Chen

Christiaen

et al. 2023

Sci Rep

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Anxiety and fear are dysfunctional behaviors commonly observed in domesticated dogs. Although dogs and humans share psychopathological similarities, little is known about how dysfunctional fear behaviors are represented in brain networks in dogs diagnosed with anxiety disorders. A combination of diffusion tensor imaging (DTI) and graph theory was used to investigate the underlying structural connections of dysfunctional anxiety in anxious dogs and compared with healthy dogs with normal behavior. The degree of anxiety was assessed using the Canine Behavioral Assessment & Research Questionnaire (C-BARQ), a widely used, validated questionnaire for abnormal behaviors in dogs. Anxious dogs showed significantly decreased clustering coefficient ($${C}_{p}$$ C p ), decreased global efficiency ($${E}_{glob}$$ E glob ), and increased small-worldness (σ) when compared with healthy dogs. The nodal parameters that differed between the anxious dogs and healthy dogs were mainly located in the posterior part of the brain, including the occipital lobe, posterior cingulate gyrus, hippocampus, mesencephalon, and cerebellum. Furthermore, the nodal degree ($${K}_{i}$$ K i ) of the left cerebellum was significantly negatively correlated with “excitability” in the C-BARQ of anxious dogs. These findings could contribute to the understanding of a disrupted brain structural connectome underlying the pathological mechanisms of anxiety-related disorders in dogs.

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“…To further identify changes in the structural connectome in NTG patients, we also applied network-based statistical analysis (NBS), a non-parametric statistical method validated in connectome analysis. Compared to edge-wise comparison, NBS analysis has a greater power to identify subnetwork differences between groups while allowing control of family error rates during connection group analysis [12]. By exploring the abnormal changes in the structural network of NTG patients, this study had the potential to yield novel insights into the neurophysiological underpinnings of the disease, thus facilitating the evaluation and monitoring of its progression.…”

Section: Introductionmentioning

confidence: 99%

Abnormal Topological Organization of White Matter Structural Networks in Normal Tension Glaucoma Revealed via Diffusion Tensor Tractography

Wang,

Guo,

Wang

et al. 2023

Brain Sciences

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Background: Normal tension glaucoma (NTG) is considered a neurodegenerative disease with glaucomatous damage extending to diffuse brain areas. Therefore, this study aims to explore the abnormalities in the NTG structural network to help in the early diagnosis and course evaluation of NTG. Methods: The structural networks of 46 NTG patients and 19 age- and sex-matched healthy controls were constructed using diffusion tensor imaging, followed by graph theory analysis and correlation analysis of small-world properties with glaucoma clinical indicators. In addition, the network-based statistical analysis (NBS) method was used to compare structural network connectivity differences between NTG patients and healthy controls. Results: Structural brain networks in both NTG and NC groups exhibited small-world properties. However, the small-world index in the severe NTG group was reduced and correlated with a mean deviation of the visual field (MDVF) and retinal nerve fiber layer (RNFL) thickness. When compared to healthy controls, degree centrality and nodal efficiency in visual brain areas were significantly decreased, and betweenness centrality and nodal local efficiency in both visual and nonvisual brain areas were also significantly altered in NTG patients (all p < 0.05, FDR corrected). Furthermore, NTG patients exhibited increased structural connectivity in the occipitotemporal area, with the left fusiform gyrus (FFG.L) as the hub (p < 0.05). Conclusions: NTG exhibited altered global properties and local properties of visual and cognitive-emotional brain areas, with enhanced structural connections within the occipitotemporal area. Moreover, the disrupted small-world properties of white matter might be imaging biomarkers for assessing NTG progression.

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White matter structural network disturbances in first-episode, drug-naïve adolescents with generalized anxiety disorder

Cited by 9 publications

References 93 publications

Large-Scale Exploration of Whole-Brain Structural Connectivity in Anorexia Nervosa: Alterations in the Connectivity of Frontal and Subcortical Networks

Large-Scale Exploration of Whole-Brain Structural Connectivity in Anorexia Nervosa: Alterations in the Connectivity of Frontal and Subcortical Networks

Structural connectome alterations in anxious dogs: a DTI-based study

Abnormal Topological Organization of White Matter Structural Networks in Normal Tension Glaucoma Revealed via Diffusion Tensor Tractography

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