White Matter Structural Brain Connectivity of Young Healthy Individuals With High Trait Anxiety

Yang, Chunlan; Zhang, Yining; Lü, Min; Ren, Jiechuan; Li, Zhimei

doi:10.3389/fneur.2019.01421

Cited by 15 publications

(17 citation statements)

References 40 publications

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“… Baumgartner et al (2018) detected that cognitive deficits imposed by stroke were closely related to disruption of hippocampal-thalamic connectivity. Furthermore, a fMRI study of a highly anxious population indicated aberrant connectivity of the left hippocampus and thalamus ( Yang et al, 2019 ). Research has demonstrated that the connectivity between the hippocampus and thalamus affects depression to a large degree ( Im et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

Increased Resting-State Functional Connectivity of the Hippocampus in Rats With Sepsis-Associated Encephalopathy

Yao

Chen

et al. 2022

Front. Neurosci.

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BackgroundSepsis-associated encephalopathy (SAE) has been identified as a frequent complication of sepsis, featured by an aberrant level of cognitive and affective functions. The present study is designed to explore the changes in functional connectivity (FC) of the hippocampus in rats with SAE utilizing resting-state functional magnetic resonance imaging (rs-fMRI).MethodsSprague-Dawley rats were randomly assigned to the SAE and control groups. We acquired rs-fMRI data using a 7T MRI to evaluate hippocampal network functional differences between the two groups with a seed-based approach. Behavioral performance was assessed using the open field test and forced swimming test. Statistical analysis was undertaken to evaluate the correlation between the hippocampal FC and behavioral findings.ResultsCompared with the control group, the SAE group showed increased FC between the bilateral hippocampus and thalamus, septum, bed nuclei stria terminalis (BNST), left primary forelimb somatosensory cortex (S1FL), primary motor cortex (M1), and inferior colliculus. Increased FC between the left hippocampus and thalamus, septum, BNST, left S1FL, and inferior colliculus was observed. While with the right hippocampus, FC in thalamus, septum, left S1FL and inferior colliculus was enhanced. Additionally, positive correlations were found between the hippocampal FC and the immobility time in the forced swimming test.ConclusionHippocampus-related brain networks have significant alterations in rats with SAE, and the elevated hippocampal resting-state FC was positively related to affective deficits. Changes in FC between the hippocampus and other brain regions could be a potential neuroimaging biomarker of cognitive or mental disorders triggered by SAE.

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Section: Discussionmentioning

confidence: 99%

Increased Resting-State Functional Connectivity of the Hippocampus in Rats With Sepsis-Associated Encephalopathy

Yao

Chen

et al. 2022

Front. Neurosci.

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“…Second, we relied on a relatively small sample size. While our sample size was similar to that of recent neuroimaging studies, future studies including a larger sample size would be helpful in demonstrating confident results [ 60 , 61 ]. Third, 55 patients were consuming antidepressants during the study, and several studies have found a relationship between structural changes of the brain and antidepressant treatment [ 62 ].…”

Section: Discussionmentioning

confidence: 84%

Association between Uncinate Fasciculus Integrity and Agoraphobia Symptoms in Female Patients with Panic Disorder

Kim

Bang

Won

et al. 2021

Clin Psychopharmacol Neurosci

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Objective Although neural correlates of sub-clinical agoraphobia (AG) symptoms have been previously suggested, only a few studies evaluating structural changes of the brain have been conducted in agoraphobic patients with panic disorder (PD). We investigated and compared white matter (WM) micro-structural alterations between PD patients with AG (PD ＋ AG) and those without AG (PD − AG). Methods Our study included 56 female PD patients, of which 25 were diagnosed with AG and 31 were diagnosed without AG. Diffusion tensor imaging was performed to investigate micro-structural changes in the WM tracts related to fronto-temporo-occipital areas (uncinate fasciculus, cingulum bundle, inferior longitudinal/fronto-occipital fasciculus, fornix column and body, and fornix/stria terminalis). All participants were subjected to the Anxiety Sensitivity Inventory-Revised (ASI-R), Beck Depression Inventory-II (BDI-II), and Albany Panic and Phobia questionnaires. Results The fractional anisotropy values of the right uncinate fasciculus in PD ＋ AG were significantly lower than that of PD − AG and showed significant correlations with BDI-II and ASI-R total scores. Mean diffusivity and radial diffusivity values of the right uncinate fasciculus were significantly higher in PD ＋ AG as compared to PD − AG. Conclusion Our findings suggest that the uncinate fasciculus may be associated with AG symptoms in PD, possibly through demyelination. Our findings may contribute to the neurobiological evidence regarding the association between AG and WM structural changes in PD.

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“…At the cortex, the ventral anterior insula is responsible for integrating information from subcortical and cortical regions ( Craig et al, 2009 ; Nagai et al, 2010 ), using that information to detect salient events, and facilitate resource allocation in other attentional networks to guide proper response ( Menon and Uddin, 2010 ). Connectivity between the ventral anterior insula and medial orbitofrontal cortex has been directly associated with anxiety behaviors ( Kim et al, 2012 ; Simmons et al, 2013 ; Yang et al, 2020 ), which are driven by enhanced error monitoring, likely mediated by the basolateral amygdala, and a tendency to rely on reactive control strategies ( Braver, 2012 ; Moser et al, 2013 ). In this study, we observed increased functional connectivity in this circuit that was associated with greater head-to-ball impact exposure and diminished proactive control.…”

Section: Discussionmentioning

confidence: 99%

One season of head-to-ball impact exposure alters functional connectivity in a central autonomic network

et al. 2020

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Repetitive head impacts represent a risk factor for neurological impairment in team-sport athletes. In the absence of symptoms, a physiological basis for acute injury has not been elucidated. A basic brain function that is disrupted after mild traumatic brain injury is the regulation of homeostasis, instantiated by activity across a specific set of brain regions that comprise a central autonomic network. We sought to relate head-to-ball impact exposure to changes in functional connectivity in a core set of central autonomic regions and then to determine the relation between changes in brain and changes in behavior, specifically cognitive control. Thirteen collegiate men’s soccer players and eleven control athletes (golf, cross-country) underwent resting-state fMRI and behavioral testing before and after the season, and a core group of cortical, subcortical, and brainstem regions was selected to represent the central autonomic network. Head-to-ball impacts were recorded for each soccer player. Cognitive control was assessed using a Dot Probe Expectancy task. We observed that head-to-ball impact exposure was associated with diffuse increases in functional connectivity across a core CAN subnetwork. Increased functional connectivity between the left insula and left medial orbitofrontal cortex was associated with diminished proactive cognitive control after the season in those sustaining the greatest number of head-to-ball impacts. These findings encourage measures of autonomic physiology to monitor brain health in contact and collision sport athletes.

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White Matter Structural Brain Connectivity of Young Healthy Individuals With High Trait Anxiety

Cited by 15 publications

References 40 publications

Increased Resting-State Functional Connectivity of the Hippocampus in Rats With Sepsis-Associated Encephalopathy

Increased Resting-State Functional Connectivity of the Hippocampus in Rats With Sepsis-Associated Encephalopathy

Association between Uncinate Fasciculus Integrity and Agoraphobia Symptoms in Female Patients with Panic Disorder

One season of head-to-ball impact exposure alters functional connectivity in a central autonomic network

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