White matter preservation after spinal cord injury in ICAM-1/P-selectin-deficient mice

Glucocorticoid‐Induced Leucine Zipper (GILZ) Controls Inflammation and Tissue Damage after Spinal Cord Injury

“…Leukocytes that originate in bone marrow from lymphoid and myeloid precursors circulate in the peripheral blood and migrate to the sites of injury in response to damage. Some authors declare that severe SCI causes leukocyte arrest and transmigration across spinal cord endothelial barrier facilitated by endothelial adhesion molecules P‐selectin and ICAM‐1 exposition . Also, according to Farooque et colleagues, ICAM‐1 and P‐selectin knockout mice subjected to SCI show a better functional outcome during an observation period of 14 days .…”

Targeting senescent cells improves functional recovery after spinal cord injury

“…Such is the case of ICAM-1, VCAM, P-selectin, and osteopontin, which have also been shown to be upregulated in spinal-cord-injured mice and/or human patients (Bao et al, 2004;Esposito et al, 2010;Hashimoto et al, 2003;Hu et al, 2015;Jing et al, 2014;Segal et al, 1997). In fact, ICAM-1/P-selectin-deficient mice Cell Reports 36, 109334, July 6, 2021 11 Article ll OPEN ACCESS display improved functional recovery after injury (Farooque et al, 1999(Farooque et al, , 2001, while osteopontin-deficient mice exhibit less inflammation and significantly reduced area of spared white matter (Hashimoto et al, 2007).…”

Peripheral Nerve Transplantation Combined with Acidic Fibroblast Growth Factor and Chondroitinase Induces Regeneration and Improves Urinary Function in Complete Spinal Cord Transected Adult Mice

“…Removing even one factor from this approach diminishes recovery and axonal regeneration [ 8 ]. While most complex combinatorial approaches have been conducted in rats, mice can offer greater insight into genetic contributions to SCI failure [ 3 , 4 , 11 ]. Mouse studies often target a single gene or a related family of genes and have shown great promise in promoting regeneration but, thus far, have resulted in only minimal recovery [ 12 , 13 ].…”