White matter pathways underlying Chinese semantic and phonological fluency in mild cognitive impairment

Assessment of Language Function in Older Mandarin-Speaking Adults with Mild Cognitive Impairment using Multifaceted Language Tests

“…In phonemic tasks, participants are asked to provide as many words as possible on the basis of a phonological feature (e.g., a specific letter) within a specific time interval. Compared with controls without cognitive impairment, individuals with aMCI exhibited poorer performance in both fluency tasks; however, the difference in performance was more prominent in the semantic fluency task than in the phonemic fluency task [19,[26][27][28][29]. Conversely, other studies have reported either no differential deficit between semantic and phonemic fluency in individuals with single-domain aMCI [30] or greater impairment in phonemic fluency than in semantic fluency [31] in individuals with aMCI compared with controls without cognitive impairment.…”

“…Patients with dementia due to AD commonly exhibit language impairments in the aspects of verbal fluency [8,11], semantic knowledge [12,13], and connected speech processing [14,15]. Similar to the pattern observed during the early stage of AD, language function deficits in aMCI are characterized at the lexical and semantic levels by impairments in verbal fluency and confrontation naming [15][16][17][18][19]. Moreover, individuals with aMCI make more semantic coordinate errors (e.g., naming a tiger as a bear) than other types of errors in naming tasks [13,20].…”

“…The lexical-semantic deficits observed in aMCI are likely attributable to difficulties in lexical access and semantic processing, encompassing semantic representation and control [13,21]. These difficulties in semantic processing are likely linked to compromised brain networks involving temporal and frontal regions and their connections [22,23], as well as volumetric reductions in the perirhinal cortex, which is essential for integrating cross-modal object representations, especially in patients with aMCI [24,25].…”

“…Moreover, lexical tone is a specific suprasegmental feature in Mandarin Chinese and reflects the categorical perception of pitch contours for native Mandarin Chinese speakers [43]. Studies examining neural networks for language processing have revealed common and distinct patterns between Mandarin and English [19,44]. Thus, given the differences in linguistic features between the two languages, the extent to which the findings based on English speakers with aMCI are applicable to Mandarin Chinese speakers with aMCI should be explored.…”

Alzheimer hastalığı klinik ölçütlerine göre demans ve hafif kognitif bozukluk ayrımında sözel akıcılık testlerinin mini mental durum testi ile birlikte kullanılması yararlı olabilir

“…AHD'li bireylerde semantik akıcılığın fonemik akıcılığa kıyasla daha fazla bozulduğu bildirilmektedir. Semantik akıcılıkta alt kategorilerin semantik temsillerinin kullanılması ve geri getirilmesi semantik belleğe, hipopkampal yapılara, medial temporal lob yapılarına ve bu yapıların frontal bölgelerle ilişkilerine dayanmaktadır 35 . Yapılan çalışmalar temporal lob lezyonlarında semantik akıcılığın fonemik akıcılığa kıyasla daha çok etkilendiğini, frontal lob lezyonlarında ise fonemik akıcılığın etkilendiğini göstermektedir.…”