White matter microstructure in female to male transsexuals before cross-sex hormonal treatment. A diffusion tensor imaging study

Rametti, Giuseppina; Carrillo, Beatriz; Gómez‐Gil, Esther; Junqué, Carme; Segovia, Santiago; Gómez, Ángel; Guillamón, Antonio

doi:10.1016/j.jpsychires.2010.05.006

Cited by 166 publications

(133 citation statements)

References 41 publications

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“…Measured via diffusion tensor imaging (DTI), men have greater FA values than women (Rametti et al, 2011a(Rametti et al, , 2011b. Before hormonal intervention, androphilic MtF with feelings of gender incongruence that began in childhood appeared to have a white matter microstructure pattern that differs statistically from male as well as female controls (Rametti et al, 2011b).…”

Section: White Matter Studiesmentioning

confidence: 99%

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Neuroimaging studies in people with gender incongruence

Kreukels

Guillamón

2016

International Review of Psychiatry

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The current review gives an overview of brain studies in transgender people. First, we describe studies into the aetiology of feelings of gender incongruence, primarily addressing the sexual differentiation hypothesis: does the brain of transgender individuals resemble that of their natal sex, or that of their experienced gender? Findings from neuroimaging studies focusing on brain structure suggest that the brain phenotypes of trans women (MtF) and trans men (FtM) differ in various ways from control men and women with feminine, masculine, demasculinized and defeminized features. The brain phenotypes of people with feelings of gender incongruence may help us to figure out whether sex differentiation of the brain is atypical in these individuals, and shed light on gender identity development. Task-related imaging studies may show whether brain activation and task performance in transgender people is sex-atypical. Second, we review studies that evaluate the effects of cross-sex hormone treatment on the brain. This type of research provides knowledge on how changes in sex hormone levels may affect brain structure and function.ARTICLE HISTORY

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Section: White Matter Studiesmentioning

confidence: 99%

“…However, their corticospinal tract is defeminized; that is, their FA values lie between those of male and female controls, and are significantly different from each of these two groups (Rametti et al, 2011a). Kranz et al (2014b) also studied white matter microstructure by DTI in MtF, FtM, control men and control women.…”

Section: White Matter Studiesmentioning

confidence: 99%

Neuroimaging studies in people with gender incongruence

Kreukels

Guillamón

2016

International Review of Psychiatry

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“…Some studies provide evidence of structural and functional differences between transsexual subjects and male/female control subjects. Both white matter microstructure pattern [2,3] and grey matter volume [4] differences were found in male-to-female (MtF) and female-to-male (FtM) subjects. Differences in cognitive functioning were found through both neuropsychological evaluation and task-fMRI experiments mostly involving the mental rotation task, a well-known gender discriminative cognitive function [5].…”

Section: Introductionmentioning

confidence: 99%

Intrinsic Cerebral Connectivity Analysis in an Untreated Female-to-Male Transsexual Subject: A First Attempt Using Resting-State fMRI

et al. 2012

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Background/Aims: Transsexualism is a gender identity disorder whose symptomatology could involve cognitive, neurobiological and psychological variance from biological sex standard. Several evidences support the hypothesis of a structural and functional brain reorganization in transgender subjects, with a different impact for male-to-female and female-to-male (FtM) subjects. Here we used resting-state fMRI to understand the similarities between the spontaneous brain connectivity of an untreated FtM subject and two male and female control groups. Methods: Both seed-voxel and atlas-based region-of-interest (ROI) approaches were used. Results: Brain areas sensitive to gender dimorphism like left lingual gyrus and precuneus showed strong similarities between the FtM subject and female control group with respect to control males, with comparable extension and location of functional connectivity maps. ROI analysis confirmed this evidence, highlighting a greater pattern of differences between the FtM subject and males and the FtM subject and females. No difference between seed-voxel results in the FtM subject and females was found. Conclusion: These data partially support the idea that untreated FtM transgender shows a functional connectivity profile comparable to female control subjects.

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“…Estas alterações não são encontradas em adultos submetidos à terapia hormonal e não dependem da orientação sexual do indivíduo 11 . Outros estudos evidenciam modificações microestruturais na substância branca do cérebro de transexuais mulher para homem, sugerindo que alguns fascículos não completaram o processo de masculinização durante o desenvolvimento 12 . Estas alterações no sistema nervoso central dos transexuais reforçam a teoria de que o transexualismo está associado a modificações na diferenciação do cérebro ainda no ambiente intrauterino 13,14 .…”

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