White matter microstructure deteriorates across cognitive stages in Parkinson disease

Melzer, Tracy R.; Watts, Richard; MacAskill, Michael R.; Pitcher, Toni L.; Livingston, Leslie; Keenan, Rāwiri; Dalrymple‐Alford, John C.; Anderson, Tim

doi:10.1212/wnl.0b013e3182929f62

Cited by 129 publications

(161 citation statements)

References 41 publications

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“…White matter changes in these regions were consistently reported in previous TBSS findings (Agosta et al 2013a, b;Deng et al 2013;Hattori et al 2012;Matsui et al 2007;Melzer et al 2013;Rae et al 2012). We detected group differences with an increase in MD (but not in FA) in our patients.…”

Section: Discussionsupporting

confidence: 89%

“…Our findings combined with previous studies (Agosta et al 2013b;Gallagher et al 2013;Hattori et al 2012;Melzer et al 2013) suggest that frontal white matter damage is a core pathological substrate of mild cognitive deficits in PD. White matter damage did not correlate UPDRS-III scores.…”

Section: Discussionsupporting

confidence: 85%

“…We detected group differences with an increase in MD (but not in FA) in our patients. MD appears to be more sensitive in detecting subtle white matter changes than FA as suggested in other studies in early PD (Melzer et al 2013), early Alzheimer patients (Acosta-Cabronero et al 2010) and individuals with concussion (Cubon et al 2011). …”

Section: Discussionmentioning

confidence: 59%

“…FA and MD in the whole-brain white matter can be assessed using voxel-based analysis (VBA) or tractbased statistical analysis (TBSS). Contrary to gray matter findings, in which regional changes are more common in non-demented PD, white matter changes are reported in more diffuse brain areas even in non-demented PD (Hattori et al 2012;Kim et al 2013;Melzer et al 2013;Theilmann et al 2013;Zheng et al 2014), and the frontal region was one of the most consistently reported regions for white matter changes (Agosta et al 2013b;Deng et al 2013;Gattellaro et al 2009;Rae et al 2012;Zhan et al 2012;Zhang et al 2011). Moreover, variability in FA and/ or MD was primarily associated with cognitive measures (Agosta et al 2013b;Gallagher et al 2013;Rae et al 2012;Theilmann et al 2013;Zheng et al 2014.…”

Section: Introductionmentioning

confidence: 70%

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Imaging changes associated with cognitive abnormalities in Parkinson’s disease

et al. 2014

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The current study investigates both gray and white matter changes in non-demented Parkinson's disease (PD) patients with varying degrees of mild cognitive deficits and elucidates the relationships between the structural changes and clinical sequelae of PD. Twenty-six PD patients and 15 healthy controls (HCs) were enrolled in the study. Participants underwent T1-weighted and diffusion tensor imaging (DTI) scans. Their cognition was assessed using a neuropsychological battery. Compared with HCs, PD patients showed significant cortical thinning in sensorimotor (left pre-and postcentral gyri) and cognitive (left dorsolateral superior frontal gyrus [DLSFG]) regions. The DLSFG cortical thinning correlated with executive and global cognitive impairment in PD patients. PD patients showed white matter abnormalities as well, primarily in bilateral frontal and temporal regions, which also correlated with executive and global cognitive impairment. These results seem to suggest that both gray and white matter changes in the frontal regions may constitute an early pathological substrate of cognitive impairment of PD providing a sensitive biomarker for brain changes in PD.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 59%

Section: Introductionmentioning

confidence: 70%

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Imaging changes associated with cognitive abnormalities in Parkinson’s disease

et al. 2014

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“…In the present study, frequency of MCI in PD patients was 28%, which is consistent with the findings from Litvan et al Another study found that as per Movement Disorder Society criteria involving 109 patients, 28 (26%) patients had MCI (Melzer et al, 2013).…”

Section: Discussionsupporting

confidence: 92%

Mild cognitive impairment in Parkinson's disease and vascular risk factors among Indian patients

Dhikav¹,

Sethi²,

Anand³

2015

Int. Psychogeriatr.

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The influence of white matter hyperintensity on cognitive impairment in Parkinson's disease

Liu

Deng

Xie

et al. 2021

Ann Clin Transl Neurol

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The aim of this meta‐analysis was to review systematically and to identify the relationship between the severity and location of white matter hyperintensities (WMHs) and the degree of cognitive decline in patients with Parkinson’s disease (PD). We searched the PubMed, EMBASE, Web of Science, Ovid, and Cochrane Library databases for clinical trials of the severity and location of WMHs on the degree of cognitive impairment in PD through October 2020. We conducted the survey to compare the association of WMH burden in patients with PD with mild cognitive impairment (PD‐MCI) versus those with normal cognition (PD‐NC) and in patients with PD with dementia (PDD) versus those with PD without dementia (PD‐ND). Nine studies with PD‐MCI versus PD‐NC and 10 studies with PDD versus PD‐ND comparisons were included. The WMH burden in PD‐MCI patients was significantly different compared to that in PD‐NC patients (standard mean difference, SMD = 0.39, 95% CI: 0.12 to 0.66, p = 0.005), while there was no correlation shown in the age‐matched subgroup of the comparison. In addition, PDD patients had a significantly higher burden of WMHs (SMD = 0.8, 95% CI: 0.44 to 1.71, p < 0.0001), especially deep white matter hyperintensities (SMD = 0.54, 95% CI: 0.36 to 0.73, p < 0.00001) and periventricular hyperintensities (SMD = 0.70, 95% CI: 0.36 to 1.04, p < 0.0001), than PD‐NC patients, regardless of the adjustment of age. WMHs might be imaging markers for cognitive impairment in PDD but not in PD‐MCI, regardless of age, vascular risk factors, or race. Further prospective studies are needed to validate the conclusions.

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White matter microstructure deteriorates across cognitive stages in Parkinson disease

Cited by 129 publications

References 41 publications

Imaging changes associated with cognitive abnormalities in Parkinson’s disease

Imaging changes associated with cognitive abnormalities in Parkinson’s disease

Mild cognitive impairment in Parkinson's disease and vascular risk factors among Indian patients

The influence of white matter hyperintensity on cognitive impairment in Parkinson's disease

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