White matter microstructure before and after 6 weeks of insomnia interventions

Bresser, Tom; Leerssen, Jeanne; Hölsken, S.; Foster-Dingley, Jessica C.; Someren, Eus J.W. Van

doi:10.1016/j.sleep.2022.05.392

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“…Data were acquired during four studies performed between 2014 and 2021 by the Sleep & Cognition group at the Netherlands Institute for Neuroscience, Amsterdam (30)(31)(32).…”

Section: Participantsmentioning

confidence: 99%

Insomnia subtypes have differentiating deviations in brain structural connectivity

Bresser,

Blanken,

de Lange

et al. 2023

Preprint

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ObjectiveInsomnia disorder is the most common sleep disorder. A better understanding of insomnia-related deviations in the brain could inspire better treatment. Insufficiently recognized heterogeneity within the insomnia population could obscure involved brain circuits. The present study investigated whether structural brain connectivity deviations differ between recently discovered and validated insomnia subtypes.MethodsStructural and diffusion weighted 3-Tesla MRI data of four independent studies were harmonized. The sample consisted of 73 controls without sleep complaints and 204 participants with insomnia grouped into five subtypes based on their fingerprint of personality and mood traits assessed with the Insomnia Type Questionnaire. Linear regression correcting for age, sex, and brain volume evaluated group differences in structural connectivity strength, indicated by fractional anisotropy and mean diffusivity, and evaluated within two different atlases.ResultsInsomnia subtypes showed differentiating profiles of deviating structural connectivity which moreover concentrated in different functional networks. Permutation testing against randomly drawn heterogeneous subsamples indicated significant specificity of deviation profiles in four of the five subtypes:highly distressed(p=0.019), moderately distressed reward insensitive(p=0.014), slightly distressed low reactive(p=0.006) andslightly distressed high reactive(p=0.006).ConclusionsOur results provide a first indication that different insomnia subtypes exhibit distinct profiles of deviations in structural brain connectivity. Subtyping of insomnia could be essential for a better understanding of brain mechanisms that contribute to insomnia vulnerability.

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“…Data were acquired during four studies performed between 2014 and 2021 by the Sleep & Cognition group at the Netherlands Institute for Neuroscience, Amsterdam (30)(31)(32).…”

Section: Participantsmentioning

confidence: 99%

Insomnia subtypes have differentiating deviations in brain structural connectivity

Bresser,

Blanken,

de Lange

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

White matter microstructure before and after 6 weeks of insomnia interventions

Cited by 1 publication

References 0 publications

Insomnia subtypes have differentiating deviations in brain structural connectivity

Insomnia subtypes have differentiating deviations in brain structural connectivity

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