White matter microstructure and serum biomarkers of inflammation in psychogenic non-epileptic seizures

Mueller, Christina; Szaflarski, Jerzy P.

doi:10.1016/j.nicl.2023.103462

Cited by 1 publication

(4 citation statements)

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“…24 Finally, MCP-1 is a chemokine involved in regulating the migration of monocytes and macrophages into the brain that has been linked to depression. 25 The HC data have been previously reported as part of a repeatability analysis in Sharma et al 26 The serum biomarker and questionnaire data in the FS and PC groups have been previously reported in Mueller et al 11 as part of an analysis investigating relationships between inflammatory biomarkers and white matter microstructure in FS.…”

Section: Methodsmentioning

confidence: 99%

“…To date, only two studies have directly tested inflammatory biomarkers in FS. 10 , 11 Gledhill et al found elevations in TNF-related apoptosis-inducing ligand (TRAIL) and intercellular adhesion molecule (ICAM)-1 within 24 hours following FS compared to patients with epileptic seizures. In contrast, tumor necrosis factor (TNF) receptor 1 (TNF-R1) and monocyte chemoattractant protein (MCP)-1 were elevated following epileptic seizures compared to FS, supporting the idea that epileptic seizures and FS may have distinct inflammatory signatures.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…12 We recently described relationships between inflammatory biomarkers and white matter microstructure in the current study sample, showing associations between TNF-R1, interleukin (IL)-6, and ICAM-1, and neurite morphology in the uncinate fasciculus of FS patients, among other findings. 11 Although NI may be difficult to quantify directly, advanced neuroimaging techniques allow us to detect metabolic abnormalities that point to the presence of NI. [13][14][15] Magnetic Resonance Spectroscopic Imaging (MRSI) quantifies a number of brain metabolites that may be associated with NI, including choline (CHO), myo-inositol (MINO), and N-Acetyl-aspartate (NAA).…”

Section: Introductionmentioning

confidence: 99%

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Peripheral and Central Nervous System Biomarkers of Inflammation in Functional Seizures: Assessment with Magnetic Resonance Spectroscopy

Mueller,

Sharma,

Szaflarski

2023

NDT

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Purpose Inflammation may link trauma to clinical symptoms in functional seizures (FS). We compared brain temperature and metabolites in FS, psychiatric (PCs) and healthy controls (HCs) and quantified their associations with serum biomarkers of inflammation and clinical symptoms. Patients and Methods Brain temperature and metabolites were measured with whole-brain magnetic resonance spectroscopic imaging (MRSI) and compared between groups in regions of interest and the whole brain. Relationships with inflammatory biomarkers and symptoms were assessed with Pearson correlations. Results Brain temperature was higher in FS than HCs in the orbitofrontal cortex (OFC) and anterior cingulate gyrus (ACG) and lower in the occipital cortex and frontal lobe. PCs showed lower temperatures than HCs in the frontal lobe including precentral gyrus and in the cerebellum. Myo-inositol (MINO) was higher in FS than HCs in the precentral gyrus, posterior temporal gyrus, ACG and OFC, and choline (CHO) was higher in the occipital lobe. CHO was higher in PCs than HCs in the ACG and OFC, and N-acetylaspartate (NAA) was higher in the ACG. There were no significant correlations with the serum inflammatory biomarkers. In FS, brain temperature correlated with depression, quality of life, psychological symptoms, and disability, CHO correlated with disability, and MINO correlated with hostility, disability, and quality of life. Conclusion Some of the previously identified neuroimaging abnormalities in FS may be related to comorbid psychiatric symptoms, while others, such as abnormalities in sensorimotor cortex, occipital regions, and the temporo-parietal junction may be specific to FS. Overlapping MINO and temperature increases in the ACG and OFC in FS suggest neuroinflammation.

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