White Matter Microstructure and Apathy Level in Amnestic Mild Cognitive Impairment

Cacciari, Claudia; Moraschi, Marta; Paola, Margherita Di; Cherubini, Andrea; Orfei, Maria Donata; Giove, Federico; Maraviglia, B.; Caltagirone, Carlo; Spalletta, Gianfranco

doi:10.3233/jad-2010-1384

Cited by 38 publications

(43 citation statements)

References 35 publications

(36 reference statements)

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“…An MRI study using voxel-based morphometry found that apathy was associated with atrophy of the anterior cingulate, ventrolateral orbitofrontal cortex, and left insula in AD 45. Other studies using MRI with diffusion tensor imaging have shown relationships between increased white matter abnormalities and apathy in MCI and AD 15,17,46. A recent study found that the presence of lesions in the anterior thalamic radiations was associated with the severity of apathy in aMCI 16.…”

Section: Discussionmentioning

confidence: 99%

“…Studies using different modalities including structural magnetic resonance imaging (MRI), positron emission tomography (PET) and single photon emission computed tomography (SPECT) have shown associations among apathy and cortical thinning, white matter integrity change, hypometabolism and hypoperfusion in the orbitofrontal, anterior cingulate and inferior temporal areas in the brains of AD patients 9–15. Additionally, several studies showed that the presence of white matter lesions was associated with apathy in aMCI patients 16,17. Although strong evidence indicates that apathy is correlated with these specific brain damages that might affect disconnection of the cortico-subcortical network, the direct effects of apathy on the functional connectivity (FC) of the brain remain unclear.…”

Section: Introductionmentioning

confidence: 99%

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Apathy and intrinsic functional connectivity networks in amnestic mild cognitive impairment

Joo¹,

Lee²,

Lim³

2016

NDT

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BackgroundAlthough several prior works reported that apathy is associated with conversion to Alzheimer’s disease in individuals with amnestic mild cognitive impairment (aMCI), effects of apathy on the functional connectivity (FC) of the brain remain unclear. In this study, we assessed the pattern of association between apathy and default mode network (DMN), salience network and central executive network (CEN) in aMCI subjects.MethodsFifty subjects with aMCI and 50 controls (CONs) participated in this study. They underwent clinical assessments and magnetic resonance imaging for the structural and resting-state scan. We explored the patterns of association between apathy inventory (IA) total score and the whole-brain voxel-wise FCs of the DMN, salience network and CEN in aMCI subjects.ResultsWe observed that the FCs of the DMN were less and those of CEN were more in the aMCI group than the CON group. Total IA score was negatively correlated with FCs of the anterior cingulate within the DMN, and positively correlated with FCs of the middle frontal, inferior frontal, and supramarginal gyrus within the CEN in the aMCI group.ConclusionOur findings suggest that distinctive patterns of association between apathy and FCs in the DMN and CEN in the aMCI group might reflect the putative role of functional network change in the development of apathy in aMCI.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Apathy and intrinsic functional connectivity networks in amnestic mild cognitive impairment

Joo¹,

Lee²,

Lim³

2016

NDT

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“…WMH is a recognized structural correlate of apathy in Alzheimer's disease [36] and healthy elderly people [37]. Diffusion tensor imaging has also revealed correlations between white-matter microstructural deficits and apathy in mild cognitive impairment [38] and HIV [39]. …”

Section: Discussionmentioning

confidence: 99%

Location of Infarcts and Apathy in Ischemic Stroke

Tang¹,

Chen

Liang³

et al. 2013

Cerebrovasc Dis

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Background: Apathy is common in stroke survivors. Unlike poststroke depression, apathy after stroke has not been extensively investigated and the significance of the location of infarcts in the development of apathy following a stroke is unknown. This study examined the association between poststroke apathy (PSA) and the location of infarcts. Methods: A cohort of 185 patients with acute ischemic stroke admitted to the Stroke Unit of a university-affiliated regional hospital in Hong Kong was recruited. Three months after the index stroke, a psychiatrist administered the Apathy Evaluation Scale (AES). PSA was defined as an AES score of 37 or above. The presence and location of infarcts were evaluated with magnetic resonance imaging. Results: Altogether 185 patients met the entry criteria and formed the study sample; 20 (10.8%) had PSA. PSA patients were older and had higher stroke severity and more depressive symptoms. The PSA group also had lower levels of physical and cognitive functioning. Compared with the non-PSA group, PSA patients were more likely to have acute pontine infarcts (35.0% vs. 11.5%; p = 0.011). They had a higher mean number (0.5 ± 0.7 vs. 0.1 ± 0.3; p = 0.003) and larger volume (0.6 ± 1.4 vs. 0.1 ± 0.3 ml; p = 0.002) of acute pontine infarcts. Six variables were entered into the predictive regression model: age, the presence, number and volume of acute pontine infarcts, the number of old infarcts and periventricular white matter hyperintensities scores. The volume of infarcts remained an independent predictor of PSA in the multivariate analysis, with an odds ratio of 3.9 (p = 0.007). The Geriatric Depression Scale, National Institutes of Health Stroke Scale, Barthel Index and Mini-Mental State Examination scores were also entered into the subsequent associative regression model; the volume of acute pontine infarcts remained a significant predictor (odds ratio = 3.8). Conclusions: This is the first report of an association between pontine infarcts and the risk of PSA. The results suggest that pontine infarcts may play a role in the development of PSA. The importance of acute pontine infarcts in the pathogenesis of PSA warrants further investigation.

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“…Apathy and depression are strongly associated with both brain structural abnormalities (1-2) and dementia conversion (3-4) among individuals with Mild Cognitive Impairment (MCI), a transition state between normal aging and dementia. However, few studies have directly compared the relative prognostic values of apathy and depression in this population.…”

Section: Objectivementioning

confidence: 99%

Are Apathy and Depression Independently Associated with Longitudinal Trajectories of Cortical Atrophy in Mild Cognitive Impairment?

Zahodne¹,

Gongvatana²,

Cohen³

et al. 2013

The American Journal of Geriatric Psychiatry

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Objective We sought to examine whether depression and apathy are independently associated with longitudinal trajectories of cortical atrophy in entorhinal cortex compared to frontal subregions previously implicated in late-life mood disturbance. Design Data from 334 participants classified as having Mild Cognitive Impairment (MCI) in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) were analyzed using multilevel models for change adjusted for age, global cognitive status, and total intracranial volume at enrollment. Setting Participants in ADNI were recruited from over 50 clinical research sites in the United States and Canada. Measurements Depression and apathy were identified by informants with the Neuropsychiatric Inventory Questionnaire. Serial MRI was carried out on 1.5T scanners according to standardized ADNI-1 protocol on an average of 5 occasions over an average of 2.5 years. Regional cortical thickness values were derived from longitudinal data processing in Freesurfer version 4.4. Results Depression was associated with reduced cortical thickness in the entorhinal cortex at baseline and accelerated atrophy in anterior cingulate cortex. Similarly-sized relationships between depression and orbitofrontal cortex and between apathy and anterior cingulate cortex were not significant. Conclusions In MCI, depression signs are a better marker of longitudinal cortical atrophy than apathy. Results are consistent with hypotheses that depression is an early sign of a more aggressive neurodegenerative process or that depression lowers brain reserve capacity, allowing for more rapid progression of AD neuropathology.

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White Matter Microstructure and Apathy Level in Amnestic Mild Cognitive Impairment

Cited by 38 publications

References 35 publications

Apathy and intrinsic functional connectivity networks in amnestic mild cognitive impairment

Apathy and intrinsic functional connectivity networks in amnestic mild cognitive impairment

Location of Infarcts and Apathy in Ischemic Stroke

Are Apathy and Depression Independently Associated with Longitudinal Trajectories of Cortical Atrophy in Mild Cognitive Impairment?

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