White matter microstructural recovery with abstinence and decline with relapse in alcohol dependence interacts with normal ageing: a controlled longitudinal DTI study

Pfefferbaum, Adolf; Rosenbloom, Margaret J.; Chu, Weiwei; Sassoon, Stephanie A.; Rohlfing, Torsten; Pohl, Kilian M.; Zahr, Natalie M.; Sullivan, Edith V.

doi:10.1016/s2215-0366(14)70301-3

Cited by 100 publications

(111 citation statements)

References 31 publications

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“…1) within similar tracts previously reported (Pfefferbaum et al, 2006; Harris et al, 2008; Durkee et al, 2013; Pfefferbaum et al, 2014; Segobin et al., 2015; Sorg et al, 2015). The FA deficits imply disruptions in these fibers due to axonal deletion (de la Monte et al, 2014), demyelination (Pfefferbaum and Sullivan, 2005), and/or microtubule disruptions (Mayfield et al, 2002), which can impair inhibitory control (Baler and Volkow, 2006), working memory, and visuospatial performance in alcohol-dependent individuals (Pfefferbaum et al, 2006).…”

Section: Discussionsupporting

confidence: 88%

“…Similar recovery of WM microstructure in ALC has been reported using other analysis methods (Gazdzinski et al, 2010; Pfefferbaum et al, 2014). Longitudinal recovery was also reported for WM volumes in ALC over 7.5 months of abstinence (Durazzo et al, 2015) and for the WM microstructure in ALC who abstained for ten years (Pfefferbaum et al, 2014).…”

Section: Discussionsupporting

confidence: 85%

“…We applied TBSS for determining microstructural differences between treatment-seeking alcohol-dependent individuals and light drinkers: FA was lower in fibers within frontal WM, limbic pathways, and between cortico-striatal regions; in the small group of patients, associations between drinking severity and regional FA were insignificant (Yeh et al, 2009). Other TBSS studies in alcohol dependence reported FA deficits specifically within cingulum, corpus callosum, fornix (Durkee et al, 2013; Trivedi et al, 2013; Pfefferbaum et al., 2014; Smith et al, 2015; Sorg et al, 2015), and superior longitudinal fasciculus (Pfefferbaum et al, 2014; Segobin et al, 2015). Microstructural abnormalities were most pronounced in major tracts within frontal WM (Fortier et al, 2014; Pfefferbaum et al, 2014; Sorg et al, 2015) and related to higher lifetime alcohol consumption (Sorg et al, 2015).…”

Section: Introductionmentioning

confidence: 95%

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Effects of abstinence and chronic cigarette smoking on white matter microstructure in alcohol dependence: Diffusion tensor imaging at 4 T

Zou

Murray

Durazzo

et al. 2017

Drug and Alcohol Dependence

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Background We previously reported widespread microstructural deficits of brain white matter in alcohol-dependent individuals (ALC) compared to light drinkers in a small 1.5 Tesla diffusion tensor imaging study employing tract-based spatial statistics. Using a larger dataset acquired at 4 Tesla, the present study is an extension that investigated the effects of alcohol consumption, abstinence from alcohol, and comorbid cigarette smoking on white matter microstructure. Methods Tract-based spatial statistics were performed on 20 1-week-abstinent ALC, 52 1-month-abstinent ALC, and 30 controls. Regional measures of fractional anisotropy (FA) and mean diffusivity (MD) in the significant clusters were compared by Analysis of Covariance. The metrics were correlated with substance use history and behavioral measures. Results 1-week-abstinent ALC showed lower FA than controls in the corpus callosum, right cingulum, external capsule, and hippocampus. At 1 month of abstinence, only the FA in the body of the corpus callosum of ALC remained significantly different from controls. Some regional FA deficits correlated with more severe measures of drinking and smoking histories but only weakly with mood and impulsivity measures.. Conclusion White matter microstructure is abnormal during early abstinence in alcohol dependent treatment seekers and recovers into the normal range within about four weeks. The compromised white matter was related to substance use severity, mood, and impulsivity. Our findings suggest that ALC may benefit from interventions that facilitate normalization of DTI metrics to maintain abstinence, via smoking cessation, cognitive-based therapy, and perhaps pharmacology to support remyelination.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 95%

See 1 more Smart Citation

Effects of abstinence and chronic cigarette smoking on white matter microstructure in alcohol dependence: Diffusion tensor imaging at 4 T

Zou

Murray

Durazzo

et al. 2017

Drug and Alcohol Dependence

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“…These results were expected for GM [8], but the global nature of associations between alcohol use and WM integrity was surprising; even at an increased significance threshold, approximately 30% of voxels in the WM skeleton showed negative association between AUDIT score and WM integrity. WM damage in adult hazardous alcohol users may be partially reversed with extended abstinence [75–77], but the current results underline the importance of increasing efforts for early and effective treatments for AUDs. Further, identification of specific brain regions impacted by alcohol use throughout the lifespan may aid in the development of more efficacious pharmacological treatment options.…”

Section: Discussionmentioning

confidence: 99%

Structural neuroimaging correlates of alcohol and cannabis use in adolescents and adults

et al. 2017

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Background and Aims Chronic alcohol use is associated with lower gray matter volume, and we recently reported that alcohol use showed negative associations with widespread gray matter (GM) volume even among young adults. The current study aimed to test the strength of association between (1) alcohol use and GM volume; (2) alcohol use and white matter (WM) integrity; (3) cannabis use and GM volume; and (4) cannabis use and WM integrity among adults and adolescents. Design and Setting General linear models within large pooled cross-sectional samples of adolescents and adults who had participated in studies collecting substance use and neuroimaging data in the southwestern United States. Participants The current analysis included adults ages 18–55 years (N=853) and adolescents ages 14–18 years (N=439) with a range of alcohol and cannabis use. Measurements The dependent variable was GM volume or WM integrity, with key predictors of alcohol use (AUDIT score) and cannabis use (past 30-day use). Findings Alcohol use showed large clusters of negative associations (ηp2=.028 to .145, p<.001) with GM volume among adults, and to a lesser extent (one cluster; ηp2=.070, p<.05) among adolescents. Large clusters showed significant associations (ηp2=.050 to .124, p<.001) of higher alcohol use with poorer WM integrity, whereas adolescents showed no significant associations between alcohol use and WM. No associations were observed between structural measures and past 30-day cannabis use in adults or adolescents. Conclusions Alcohol use severity is associated with widespread lower gray matter volume and white matter integrity in adults, and with lower gray matter volume in adolescents.

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“…Similarly, Pfefferbaum et al (2014) reported decline in FA across white matter in 56 older individuals over 1–8 years (control sample).…”

mentioning

confidence: 89%

White Matter Integrity Declined Over 6-Months, but Dance Intervention Improved Integrity of the Fornix of Older Adults

Burzyńska

Jiao

Knecht

et al. 2017

Front. Aging Neurosci.

120

110

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Degeneration of cerebral white matter (WM), or structural disconnection, is one of the major neural mechanisms driving age-related decline in cognitive functions, such as processing speed. Past cross-sectional studies have demonstrated beneficial effects of greater cardiorespiratory fitness, physical activity, cognitive training, social engagement, and nutrition on cognitive functioning and brain health in aging. Here, we collected diffusion magnetic resonance (MRI) imaging data from 174 older (age 60–79) adults to study the effects of 6-months lifestyle interventions on WM integrity. Healthy but low-active participants were randomized into Dance, Walking, Walking + Nutrition, and Active Control (stretching and toning) intervention groups (NCT01472744 on ClinicalTrials.gov). Only in the fornix there was a time × intervention group interaction of change in WM integrity: integrity declined over 6 months in all groups but increased in the Dance group. Integrity in the fornix at baseline was associated with better processing speed, however, change in fornix integrity did not correlate with change in processing speed. Next, we observed a decline in WM integrity across the majority of brain regions in all participants, regardless of the intervention group. This suggests that the aging of the brain is detectable on the scale of 6-months, which highlights the urgency of finding effective interventions to slow down this process. Magnitude of WM decline increased with age and decline in prefrontal WM was of lesser magnitude in older adults spending less time sedentary and more engaging in moderate-to-vigorous physical activity. In addition, our findings support the anterior-to-posterior gradient of greater-to-lesser decline, but only in the in the corpus callosum. Together, our findings suggest that combining physical, cognitive, and social engagement (dance) may help maintain or improve WM health and more physically active lifestyle is associated with slower WM decline. This study emphasizes the importance of a physically active and socially engaging lifestyle among aging adults.

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White matter microstructural recovery with abstinence and decline with relapse in alcohol dependence interacts with normal ageing: a controlled longitudinal DTI study

Cited by 100 publications

References 31 publications

Effects of abstinence and chronic cigarette smoking on white matter microstructure in alcohol dependence: Diffusion tensor imaging at 4 T

Effects of abstinence and chronic cigarette smoking on white matter microstructure in alcohol dependence: Diffusion tensor imaging at 4 T

Structural neuroimaging correlates of alcohol and cannabis use in adolescents and adults

White Matter Integrity Declined Over 6-Months, but Dance Intervention Improved Integrity of the Fornix of Older Adults

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