White matter microstructural organizations in patients with severe treatment-resistant schizophrenia: A diffusion tensor imaging study

Ochi, Ryo; Noda, Yoshihiro; Tsuchimoto, Shohei; Tarumi, Ryosuke; Honda, Shiori; Matsushita, Karin; Tsugawa, Sakiko; Plitman, Eric; Masuda, Fumi; Ogyu, Kamiyu; Wada, Masataka; Miyazaki, Takahiro; Fujii, Shinya; Chakravarty, M. Mallar; Graff‐Guerrero, Ariel; Uchida, Hiroyuki; Mimura, Masaru; Nakajima, Shinichiro

doi:10.1016/j.pnpbp.2020.109871

Cited by 27 publications

(24 citation statements)

References 36 publications

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“…As many as one-third of patients may not improve after treatment with neuroleptics (excluding clozapine) [ 50 ]. It turns out that drug-resistant patients, in comparison to patients who respond well to antipsychotic treatment, have reduced FA values in many white matter pathways (e.g., the corona radiata, corpus callosum, internal capsule, superior longitudinal fasciculus, or arcuate fasciculus) [ 32 , 51 ]. However, an increase in RD value has been observed in the corpus callosum, internal and external capsule, and the right inferior longitudinal fasciculus [ 32 ], which may make the use of other biological therapy methods more effective, improving the prognosis of such patients.…”

Section: White Matter Abnormalities In Schizophreniamentioning

confidence: 99%

Magnetic resonance diffusion tensor imaging in psychiatry: a narrative review of its potential role in diagnosis

et al. 2020

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Diffusion tensor imaging (DTI) is an imaging technique that uses magnetic resonance. It measures the diffusion of water molecules in tissues, which can occur either without restriction (i.e., in an isotropic manner) or limited by some obstacles, such as cell membranes (i.e., in an anisotropic manner). Diffusion is most often measured in terms of, inter alia, fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD). DTI allows us to reconstruct, visualize, and evaluate certain qualities of white matter. To date, many studies have sought to associate various changes in the distribution of diffusion within the brain with mental diseases and disorders. A better understanding of white matter integrity disorders can help us recognize the causes of diseases, as well as help create objective methods of psychiatric diagnosis, identify biomarkers of mental illness, and improve pharmacotherapy. The aim of this work is to present the characteristics of DTI as well as current research on its use in schizophrenia, affective disorders, and other mental disorders.

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Section: White Matter Abnormalities In Schizophreniamentioning

confidence: 99%

Magnetic resonance diffusion tensor imaging in psychiatry: a narrative review of its potential role in diagnosis

et al. 2020

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“…Smaller internal capsule size is found in schizophrenic patients with poor outcomes in comparison to subjects with good outcomes (Brickman et al, 2006). White matter integrity measured by dMRI TBSS is reduced in treatment-resistant schizophrenia compared to healthy controls and treatment-responsive patients (Ochi et al, 2020). Connectivity as measured by dMRI TBSS is linked to faster information processing speed in older adults, although these associations did not apply to cognitive ability measured in childhood (Kuznetsova et al, 2016).…”

Section: Discussionmentioning

confidence: 90%

Brain Magnetic Resonance Imaging Phenome-Wide Association Study With Metal Transporter Gene SLC39A8

et al. 2021

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The SLC39A8 gene encodes a divalent metal transporter, ZIP8. SLC39A8 is associated with pleiotropic effects across multiple tissues, including the brain. We determine the different brain magnetic resonance imaging (MRI) phenotypes associated with SLC39A8. We used a phenome-wide association study approach followed by joint and conditional association analysis. Using the summary statistics datasets from a brain MRI genome-wide association study on adult United Kingdom (UK) Biobank participants, we systematically selected all brain MRI phenotypes associated with single-nucleotide polymorphisms (SNPs) within 500 kb of the SLC39A8 genetic locus. For all significant brain MRI phenotypes, we used GCTA-COJO to determine the number of independent association signals and identify index SNPs for each brain MRI phenotype. Linkage equilibrium for brain phenotypes with multiple independent signals was confirmed by LDpair. We identified 24 brain MRI phenotypes that vary due to MRI type and brain region and contain a SNP associated with the SLC39A8 locus. Missense ZIP8 polymorphism rs13107325 was associated with 22 brain MRI phenotypes. Rare ZIP8 variants present in a published UK Biobank dataset are associated with 6 brain MRI phenotypes also linked to rs13107325. Among the 24 datasets, an additional 4 association signals were identified by GCTA-COJO and confirmed to be in linkage equilibrium with rs13107325 using LDpair. These additional association signals represent new probable causative SNPs in addition to rs13107325. This study provides leads into how genetic variation in SLC39A8, a trace mineral transport gene, is linked to brain structure differences and may affect brain development and nervous system function.

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“…First of all, two clinical tools were commonly used in a majority of DTI research in schizophrenia the Scale for the Assessment of Negative Symptoms (SANS, Andreasen 1982) or the negative subscale of the Positive and Negative Symptoms Scale (PANSS, Kay et al, 1987;van der Gaag et al, 2006;Liemburg et al, 2013;Stiekema et al, 2016). In brief, most of the studies involving these scales find no association between their scores and reduced WM integrity, i.e., lower FA values (Fujiwara et al, 2007;Skelly et al, 2008;Abdul-Rahman et al, 2011;Choi et al, 2011;Yan et al, 2012;Kelly et al, 2018), whereas some find negative (Whitford et al, 2014;Balevich et al, 2015;Ochi et al, 2020) or positive associations (Camchong et al, 2011;Bijanki et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

On the relation of white matter brain abnormalities and the asociality symptoms in schizophrenia outpatients – a DTI study

Adamczyk¹,

Płonka²,

Kruk³

et al. 2021

Acta Neurobiologiae Experimentalis

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Recent MRI studies have shown that abnormal functional connections in schizophrenia coexist with subtle changes in the structure of axons in the brain. However, there is a discrepancy in the literature concerning the relationship between white matter abnormalities and the occurrence of negative psychopathological symptoms. In the present study, we investigate the relationship between the altered white matter structure and specific psychopathology symptoms, i.e., subscales of Positive and Negative Syndrome Scale (PANSS) and Brief Negative Symptoms Scale (BNSS) in a sample of schizophrenia outpatients. For investigation on white matter abnormalities in schizophrenia, the diffusion tensor imaging analysis of between-group differences in main diffusion parameters by tract-based spatial statistics was conducted on schizophrenia outpatients and healthy controls. Hence, the correlation of PANSS and BNSS psychopathology subscales in the clinical group with fractional anisotropy was analyzed in the 17 selected cortical regions of interest. Presented between-group results revealed widespread loss of white matter integrity located across the brain in schizophrenia outpatients. Results on the white matter relationship with psychopathology revealed the negative correlation between fractional anisotropy in the left orbital prefrontal cortex, right Heschl's gyrus, bilateral precuneus and posterior cingulate cortex and the severity of asociality, as assessed with the BNSS. In conclusion, the presented study confirms the previous evidence on the widespread white matter abnormalities in schizophrenia outpatients and indicates the existence of the subtle but specific association between fractional anisotropy in the fronto-temporo-parietal regions with the asociality.

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White matter microstructural organizations in patients with severe treatment-resistant schizophrenia: A diffusion tensor imaging study

Cited by 27 publications

References 36 publications

Magnetic resonance diffusion tensor imaging in psychiatry: a narrative review of its potential role in diagnosis

Magnetic resonance diffusion tensor imaging in psychiatry: a narrative review of its potential role in diagnosis

Brain Magnetic Resonance Imaging Phenome-Wide Association Study With Metal Transporter Gene SLC39A8

On the relation of white matter brain abnormalities and the asociality symptoms in schizophrenia outpatients – a DTI study

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