White Matter Lesions Identified by Magnetic Resonance in Women with Migraine: A Volumetric Analysis and Clinical Correlations

Abstract

Background: Repeated migraine attacks and aura could independently cause structural changes in the central nervous system. Our research aims to study the correlation of migraine type, attack frequency, and other clinical variables with the presence, volume and localization of white matter lesions (WML), in a controlled study. Methods: Sixty volunteers from a tertiary headache center were selected and divided equally into four groups: episodic migraine without aura (MoA), episodic migraine with aura (MA), chronic migraine (CM) and controls (CG). Voxel-based morphometry techniques were used to analyze WML. Results: There were no differences in WML variables between groups. There was a positive correlation between age and the number and total volume of WMLs, which persisted in the comparison categorized by size and brain lobe. Disease duration was positively correlated with the number and total volume of WML, and when controlled by age, the correlation maintained significance only for the insular lobe. Aura frequency was associated with frontal and temporal lobe WMLs. There was no statistically significant correlation between WML and other clinical variables. Conclusion: Migraine overall is not a risk factor for WML. Aura frequency is, however, associated with temporal WML. Disease duration, in adjusted analyses that account for age, is associated with insular WML.

Estresa, migraina eta hirugarren belaunaldiko terapiak

“…Honek, minaren prozesamendu disfuntzional bat dagoela erakusten du, batik-bat, integrazio multisentsoriala alteratuta dagoelako, migrainaren patogenesian paper garrantzitsua jokatuz [14]. Bestalde, migraina kronikoa duten pazienteetan mina inhibitzen duen sarearen disfuntzioa nabarmenago bat eta minaren bide zentralen sentsibilizazio handiago bat egoteak, migrainaren erasoekiko sentikortasuna azal dezake [15].…”

“…Hortaz, garun-azalak garrantzi handia du migrainan, izan ere, lobulu tenporalak, integrazio multisensorialaren eremu kortikala izanik, prozesamendu nozeptibo eta bisualean parte hartzen baitu. Hala ere, ikerketek ezin izan dute frogatu garun-azaleko aldaketa anatomikorik, baina ikusi da auraren maiztasuna lobulu tenporalaren substantzia zuriaren lesioekin lotuta dagoela [15].…”

“…Hala ere, erresonantzia magnetikoa erabiliz eginiko irudi-azterketek agerian utzi dituzte migraina-krisien sorreran funtsezko papera duten garuneko eskualdeak, besteak beste, hipotalamoa. Hipotalamoa aktibatu egiten da, bai migrainaren aurreko fasean eta bai migraina krisian, eta honek minaren bide zentralaren konektibitatea eraldatzen du, beraz, migrainaren kronifikazioan inplikatuta egon daitekeela uste da [15].…”