White matter integrity related to functional working memory networks in traumatic brain injury

Palacios, Eva M.; Sala‐Llonch, Roser; Junqué, Carme; Roig, Teresa; Tormos, J.M.; Bargalló, Núria; Vendrell, Pere

doi:10.1212/wnl.0b013e31824c465a

Cited by 81 publications

(69 citation statements)

References 36 publications

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“…44 In adults with sTBI, whole-brain FA analysis revealed positive correlations between anterior and posterior callosal subregions with visual WM performance and functional activation patterns. 83,84 The present study identified significant associations between verbal WM and integrity of callosal subregions connecting anterior and posterior parietal cortical regions, and between visuospatial WM and integrity of callosal subregions connecting anterior parietal, posterior parietal, and temporal cortical regions, across brain-injured and TD comparison children. In addition to using a larger sample than in previous pediatric studies, our results make a significant contribution because of our use of DTI tractography, rather than mid-sagittal-area DTI, allowing for stronger inferences regarding cortical terminations of callosal fibers and their effect on WM neural networks.…”

Section: Discussionmentioning

confidence: 53%

Working Memory and Corpus Callosum Microstructural Integrity after Pediatric Traumatic Brain Injury: A Diffusion Tensor Tractography Study

Treble

Hasan

Iftikhar

et al. 2013

Journal of Neurotrauma

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Deficits in working memory (WM) are a common consequence of pediatric traumatic brain injury (TBI) and are believed to contribute to difficulties in a range of cognitive and academic domains. Reduced integrity of the corpus callosum (CC) after TBI may disrupt the connectivity between bilateral frontoparietal neural networks underlying WM. In the present investigation, diffusion tensor imaging (DTI) tractography of eight callosal subregions (CC1-CC8) was examined in relation to measures of verbal and visuospatial WM in 74 children sustaining TBI and 49 typically developing comparison children. Relative to the comparison group, children with TBI demonstrated poorer visuospatial WM, but comparable verbal WM. Microstructure of the CC was significantly compromised in brain-injured children, with lower fractional anisotropy (FA) and higher axial and radial diffusivity metrics in all callosal subregions. In both groups of children, lower FA and/or higher radial diffusivity in callosal subregions connecting anterior and posterior parietal cortical regions predicted poorer verbal WM, whereas higher radial diffusivity in callosal subregions connecting anterior and posterior parietal, as well as temporal, cortical regions predicted poorer visuospatial WM. DTI metrics, especially radial diffusivity, in predictive callosal subregions accounted for significant variance in WM over and above remaining callosal subregions. Reduced microstructural integrity of the CC, particularly in subregions connecting parietal and temporal cortices, may act as a neuropathological mechanism contributing to long-term WM deficits. The future clinical use of neuroanatomical biomarkers may allow for the early identification of children at highest risk for WM deficits and earlier provision of interventions for these children.

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Section: Discussionmentioning

confidence: 53%

Working Memory and Corpus Callosum Microstructural Integrity after Pediatric Traumatic Brain Injury: A Diffusion Tensor Tractography Study

Treble

Hasan

Iftikhar

et al. 2013

Journal of Neurotrauma

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“…In a previous study, 5 we found that disrupted structural connectivity after traumatic axonal injury was responsible for altered functional connectivity during working memory performance.…”

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confidence: 75%

“…The criteria followed for sample selection have been described elsewhere. 5 This study is part of a project on long-term impairment of connectivity in diffuse TBI, and some results already have been published. 5,24 Patients' demographic and clinical characteristics are summarized in Table 1.…”

Section: Study Participantsmentioning

confidence: 99%

“…3 Functional magnetic resonance imaging (fMRI) studies suggest that white matter damage alters structural connectivity, which in turn can affect functional connectivity, and both contribute to cognitive dysfunctions in TBI. [4][5][6][7] Resting-state fMRI studies have recently emerged as a useful tool for investigating brain functional connectivity after severe TBI 4,[8][9][10][11] and in subjects with mild TBI examined during the early stages. 12,13 These studies provide information about brain activity and connectivity in the absence of task performance, a condition that allows researchers to investigate patient populations with broader ranges of injury severity, because no specific cognitive ability is required.…”

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confidence: 99%

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Resting-State Functional Magnetic Resonance Imaging Activity and Connectivity and Cognitive Outcome in Traumatic Brain Injury

Palacios¹,

et al. 2013

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“…Similarly, posterior temporal white matter may provide connections for integration between specialized regions of temporal lobe for verbal and visuospatial working memory with the posterior parietal executive attention network. Posterior temporal white matter has also been shown to relate to working memory performance in typical adults (Burzynska et al., 2011; Golestani et al., 2014) and in lesion studies (Finke, Bublak, & Zihl, 2006; Palacios et al., 2012). …”

Section: Discussionmentioning

confidence: 99%

Differences in brain morphology and working memory capacity across childhood

Bathelt

Gathercole

Johnson

et al. 2017

Developmental Science

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Working memory (WM) skills are closely associated with learning progress in key areas such as reading and mathematics across childhood. As yet, however, little is known about how the brain systems underpinning WM develop over this critical developmental period. The current study investigated whether and how structural brain correlates of components of the working memory system change over development. Verbal and visuospatial short‐term and working memory were assessed in 153 children between 5.58 and 15.92 years, and latent components of the working memory system were derived. Fractional anisotropy and cortical thickness maps were derived from T1‐weighted and diffusion‐weighted MRI and processed using eigenanatomy decomposition. There was a greater involvement of the corpus callosum and posterior temporal white matter in younger children for performance associated with the executive part of the working memory system. For older children, this was more closely linked with the thickness of the occipitotemporal cortex. These findings suggest that increasing specialization leads to shifts in the contribution of neural substrates over childhood, moving from an early dependence on a distributed system supported by long‐range connections to later reliance on specialized local circuitry. Our findings demonstrate that despite the component factor structure being stable across childhood, the underlying brain systems supporting working memory change. Taking the age of the child into account, and not just their overall score, is likely to be critical for understanding the nature of the limitations on their working memory capacity.

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White matter integrity related to functional working memory networks in traumatic brain injury

Abstract: Combining structural and functional neuroimaging data, we were able to describe structural white matter changes related to functional network alterations and to lower performance in working memory in chronic TBI.

Cited by 81 publications

References 36 publications

Working Memory and Corpus Callosum Microstructural Integrity after Pediatric Traumatic Brain Injury: A Diffusion Tensor Tractography Study

Working Memory and Corpus Callosum Microstructural Integrity after Pediatric Traumatic Brain Injury: A Diffusion Tensor Tractography Study

Resting-State Functional Magnetic Resonance Imaging Activity and Connectivity and Cognitive Outcome in Traumatic Brain Injury

Differences in brain morphology and working memory capacity across childhood

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