White Matter Integrity Predicts Delay Discounting Behavior in 9- to 23-Year-Olds: A Diffusion Tensor Imaging Study

Olson, Elizabeth A.; Collins, Paul F.; Hooper, Catalina J.; Muetzel, Ryan L.; Lim, Kelvin O.; Luciana, Mónica

doi:10.1162/jocn.2009.21107

Cited by 177 publications

(153 citation statements)

References 68 publications

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“…These studies found that greater impulsivity was significantly correlated with striatal and frontal cortical gray matter volume in partial agreement with the present findings. White matter differences related to temporal discounting have also been reported in the frontal and temporal lobes (55,56). The current study's results support a developmental imbalance model of impulsivity according to which heightened impulsivity during adolescence is a consequence of the differential growth trajectories of competing brain systems involved in choice behavior (9,11,12,15,25).…”

Section: Discussionsupporting

confidence: 79%

Brain Regions Related to Impulsivity Mediate the Effects of Early Adversity on Antisocial Behavior

Mackey

Chaarani

Kan

et al. 2017

Biological Psychiatry

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BACKGROUND: Individual differences in impulsivity and early adversity are known to be strong predictors of adolescent antisocial behavior. However, the neurobiological bases of impulsivity and their relation to antisocial behavior and adversity are poorly understood. METHODS: Impulsivity was estimated with a temporal discounting task. Voxel-based morphometry was used to determine the brain structural correlates of temporal discounting in a large cohort (n 5 1830) of 14-to 15-year-old children. Mediation analysis was then used to determine whether the volumes of brain regions associated with temporal discounting mediate the relation between adverse life events (e.g., family conflict, serious accidents) and antisocial behaviors (e.g., precocious sexual activity, bullying, illicit substance use). RESULTS: Greater temporal discounting (more impulsivity) was associated with 1) lower volume in frontomedial cortex and bilateral insula and 2) greater volume in a subcortical region encompassing the ventral striatum, hypothalamus and anterior thalamus. The volume ratio between these cortical and subcortical regions was found to partially mediate the relation between adverse life events and antisocial behavior. CONCLUSIONS: Temporal discounting is related to regions of the brain involved in reward processing and interoception. The results support a developmental imbalance model of impulsivity and are consistent with the idea that negative environmental factors can alter the developing brain in ways that promote antisocial behavior.

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Section: Discussionsupporting

confidence: 79%

Brain Regions Related to Impulsivity Mediate the Effects of Early Adversity on Antisocial Behavior

Mackey

Chaarani

Kan

et al. 2017

Biological Psychiatry

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“…Furthermore, forceps major is not assumed to be especially important for cognitive control. This assumption does not exclude the possibility that maturation of specific WM tracts can be related to more specific cognitive functions (57)(58)(59)(60), but it will likely also have general beneficial effects on major cognitive functions through facilitation of processing speed (61)(62)(63)(64)(65)(66)(67)(68)(69)(70)(71).…”

Section: Discussionmentioning

confidence: 99%

Multimodal imaging of the self-regulating developing brain

Fjell

Walhovd

Brown

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

202

185

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Self-regulation refers to the ability to control behavior, cognition, and emotions, and self-regulation failure is related to a range of neuropsychiatric problems. It is poorly understood how structural maturation of the brain brings about the gradual improvement in self-regulation during childhood. In a large-scale multicenter effort, 735 children (4-21 y) underwent structural MRI for quantification of cortical thickness and surface area and diffusion tensor imaging for quantification of the quality of major fiber connections. Brain development was related to a standardized measure of cognitive control (the flanker task from the National Institutes of Health Toolbox), a critical component of self-regulation. Ability to inhibit responses and impose cognitive control increased rapidly during preteen years. Surface area of the anterior cingulate cortex accounted for a significant proportion of the variance in cognitive performance. This finding is intriguing, because characteristics of the anterior cingulum are shown to be related to impulse, attention, and executive problems in neurodevelopmental disorders, indicating a neural foundation for self-regulation abilities along a continuum from normality to pathology. The relationship was strongest in the younger children. Properties of large-fiber connections added to the picture by explaining additional variance in cognitive control. Although cognitive control was related to surface area of the anterior cingulate independently of basic processes of mental speed, the relationship between white matter quality and cognitive control could be fully accounted for by speed. The results underscore the need for integration of different aspects of brain maturation to understand the foundations of cognitive development.executive function | cognitive conflict | inhibition | morphometry S elf-regulation enables people to make plans, choose from alternatives, control impulses, inhibit thoughts, and regulate social behavior (updated reviews in refs. 1 and 2). Several neuropsychiatric conditions and problems have been related to deficiencies in self-regulation [e.g., Attention Deficit Hyperactivity Disorder (3), addiction (4), risk behavior (5), conduct problems (6), and poor school and academic performance (7, 8)]. Although development of self-regulation in children is the result of a dynamic interaction between maturation and learning, we have scarce knowledge about the role played by structural brain characteristics in this process. Recent reports indicate that adjustment problems in childhood psychopathology are related to structural brain characteristics (9-13), but the brain basis for development of self-regulation in normal children is less well-understood. Thus, the purpose of the present paper was to use multimodal neuroimaging to map the structural brain characteristics related to self-regulation and cognitive control in a large sample of 735 children between 4 and 21 y of age.Self-regulation is closely tied to the concepts of cognitive control, attention, and executive f...

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“…Silveri et al [45] reported sex differences in fractional anisotropy (FA), a measure of white matter coherence were related to response inhibition measured by the Stroop task. A following study revealed that greater white matter anisotropy in several areas in male individuals was associated with lower impulsivity measured by a delay-discounting task [46]. Finally, maturation of medial frontal cortices in male individuals was implicated in the maturation of rational decision making and avoidance of risky choices [47].…”

Section: Impulsivity White Matter Architecture and Sex Differences Dmentioning

confidence: 91%

Is Impulsivity a Male Trait Rather than Female Trait? Exploring the Sex Difference in Impulsivity

Weinstein

Dannon

2015

Curr Behav Neurosci Rep

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Impulsivity is raising major interest clinically because it is associated with various clinical conditions such as delinquency, antisocial behavior, suicide attempts, aggression, and criminal activity. The evolutionary perspective argued that impulsivity relates to self-regulation and it has predicted that female individuals should have evolved a greater ability to inhibit pre-potent responses. There is supportive evidence showing that female individuals have better performance on cognitive tasks measuring impulsivity such as delay in gratification and delayed discounting mainly in childhood. During adolescence, brain imaging studies using diffusion tensor imaging on white matter architecture indicated contrary to the evolutionary perspective hypothesis, that young adolescent male individuals may be less vulnerable than age-matched female individuals to risk-and reward-related maladaptive behaviors. In adults, the results are mixed presumably owing to hormonal effects on neuro-biological mechanisms of reward. Consequently, female individuals were less impulsive than male individuals only during fertile stages of the menstrual cycle. Finally, there is evidence the serotonin (5-HT) system is more involved in the impulsivity of men than in that of women. Overall, there seem to be sex differences in impulsivity but these differences are more pronounced in childhood and they are later subject to maturational and hormonal changes during adolescence and adulthood and their effects on the brain, cognition, and behavior.

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White Matter Integrity Predicts Delay Discounting Behavior in 9- to 23-Year-Olds: A Diffusion Tensor Imaging Study

Cited by 177 publications

References 68 publications

Brain Regions Related to Impulsivity Mediate the Effects of Early Adversity on Antisocial Behavior

Brain Regions Related to Impulsivity Mediate the Effects of Early Adversity on Antisocial Behavior

Multimodal imaging of the self-regulating developing brain

Is Impulsivity a Male Trait Rather than Female Trait? Exploring the Sex Difference in Impulsivity

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