White matter integrity differences associated with post-traumatic stress disorder are not normalized by concurrent marijuana use

Yeh, Chien-Lin; Levar, Nina; Broos, Hannah C.; Dechert, Alyson; Potter, Kevin; Evins, A. Eden; Gilman, Jodi M.

doi:10.1016/j.pscychresns.2019.111017

Cited by 4 publications

(6 citation statements)

References 56 publications

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“…A potential factor in such WM differences is the age of trauma (Siehl et al, 2018). All our patients experienced earthquake trauma in adulthood, while some studied by Yeh et al experienced trauma below the age of 18 (Yeh et al, 2020). Note that although all participants experienced similar earthquake trauma, we cannot completely rule out the potentially confounding effects of childhood trauma exposure, as no specific standard scales (e.g., Childhood Trauma Questionnaire) were used to assess this.…”

Section: Discussionmentioning

confidence: 91%

“…medial frontal cortex and thalamus); this may contribute to failed extinction memory and extinction retention and persistent excessive fear responses in PTSD (Yin et al, 2011 ). However, increased FA is reported in the right anterior thalamic radiation in PTSD relative to TENP (Yeh et al, 2020 ). A potential factor in such WM differences is the age of trauma (Siehl et al, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

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Psychoradiological abnormalities in treatment‐naive noncomorbid patients with posttraumatic stress disorder

Suo

Lei

et al. 2021

Depression and Anxiety

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Background: Neuroimaging studies in posttraumatic stress disorder (PTSD) have identified various alterations in white matter (WM) microstructural organization.However, it remains unclear whether these are localized to specific regions of fiber tracts, and what diagnostic value they might have. This study set out to explore the spatial profile of WM abnormalities along defined fiber tracts in PTSD.Methods: Diffusion tensor images were obtained from 77 treatment-naive noncomorbid patients with PTSD and 76 demographically matched trauma-exposed non-PTSD (TENP) controls. Using automated fiber quantification, tract profiles of fractional anisotropy, axial diffusivity, mean diffusivity, and radial diffusivity were calculated to evaluate WM microstructural organization. Results were analyzed by pointwise comparisons, by correlation with symptom severity, and for diagnosis-bysex interactions. Support vector machine analyses assessed the ability of tract profiles to discriminate PTSD from TENP.Results: Compared to TENP, PTSD showed lower fractional anisotropy accompanied by higher radial diffusivity and mean diffusivity in the left uncinate fasciculus, and lower fractional anisotropy accompanied by higher radial diffusivity in the right anterior thalamic radiation. Tract profile alterations were correlated with symptom severity, suggesting a pathophysiological relevance. There were no significant differences in diagnosis-by-sex interaction. Tract profiles allowed individual classification of PTSD versus TENP with significant accuracy, of potential diagnostic utility.Conclusions: These findings add to the knowledge of the neuropathological basis of PTSD. WM alterations based on a tract-profile quantification approach are a potential biomarker for PTSD.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Psychoradiological abnormalities in treatment‐naive noncomorbid patients with posttraumatic stress disorder

Suo

Lei

et al. 2021

Depression and Anxiety

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“…Cannabis use and PTSD have also both been associated with changes in white matter tracts in the cingulum and anterior thalamic radiations [ 46 ]. In a recent study, Yeh et al sought to investigate the impact of comorbid PTSD and cannabis use on white matter tract integrity by categorizing participants into four groups including trauma-exposed individuals with no PTSD or regular cannabis, individuals with PTSD and no regular cannabis use, trauma-exposed individuals who use cannabis and do not have PTSD, individuals with PTSD and regular cannabis use [ 46 ]. The authors found that PTSD was associated with increased fractional anisotropy (FA) in the right anterior thalamic radiation, which correlated with PTSD symptom severity [ 46 ].…”

Section: Lessons From Translational and Clinical Researchmentioning

confidence: 99%

“…In a recent study, Yeh et al sought to investigate the impact of comorbid PTSD and cannabis use on white matter tract integrity by categorizing participants into four groups including trauma-exposed individuals with no PTSD or regular cannabis, individuals with PTSD and no regular cannabis use, trauma-exposed individuals who use cannabis and do not have PTSD, individuals with PTSD and regular cannabis use [ 46 ]. The authors found that PTSD was associated with increased fractional anisotropy (FA) in the right anterior thalamic radiation, which correlated with PTSD symptom severity [ 46 ]. On the other hand, cannabis use was associated with decreased FA in bilateral anterior thalamic radiata [ 46 ].…”

Section: Lessons From Translational and Clinical Researchmentioning

confidence: 99%

“…The authors found that PTSD was associated with increased fractional anisotropy (FA) in the right anterior thalamic radiation, which correlated with PTSD symptom severity [ 46 ]. On the other hand, cannabis use was associated with decreased FA in bilateral anterior thalamic radiata [ 46 ]. There was no significant interaction between PTSD and cannabis, indicating that in individuals with PTSD, cannabis use does not further alter PTSD-related alterations in this white matter tract [ 46 ].…”

Section: Lessons From Translational and Clinical Researchmentioning

confidence: 99%

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Elucidating the Neurobiologic Etiology of Comorbid PTSD and Substance Use Disorders

Hinckley

Danielson

2022

Brain Sciences

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Early childhood maltreatment and other traumatic event experiences (“trauma”) are common among youth, including those with substance use problems including substance use disorders (SUD). Particularly, interpersonal violence is associated with high rates of comorbidity between posttraumatic stress disorder (PTSD) and SUD, and these comorbid disorders exhibit high levels of overlapping symptomatology. Theoretical models proposed to explain the bidirectional relationship between PTSD and SUD include the self-medication hypothesis and susceptibility hypothesis. In this article, we explore neurobiologic changes associated with trauma, PTSD, and SUD that underly dysregulated stress response. Examining lessons learned from recent translational and clinical research, we propose that further elucidating the neurobiologic etiology of comorbid PTSD and SUD will require a collaborative, interdisciplinary approach, including the integration of preclinical and clinical studies, exploration of biologic markers in clinical studies, and accumulation of larger studies and longitudinal studies with the power to study PTSD and SUD. Such research can transform the field and ultimately reduce high rates and costly impairment of co-occurring PTSD and SUD across the lifespan.

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Aberrant white matter microstructure evaluation by automated fiber quantification in typhoon-related post-traumatic stress disorder

Zhang

Chen

et al. 2022

Brain Imaging and Behavior

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White matter integrity differences associated with post-traumatic stress disorder are not normalized by concurrent marijuana use

Cited by 4 publications

References 56 publications

Psychoradiological abnormalities in treatment‐naive noncomorbid patients with posttraumatic stress disorder

Psychoradiological abnormalities in treatment‐naive noncomorbid patients with posttraumatic stress disorder

Elucidating the Neurobiologic Etiology of Comorbid PTSD and Substance Use Disorders

Aberrant white matter microstructure evaluation by automated fiber quantification in typhoon-related post-traumatic stress disorder

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