White Matter Hyperintensity Associations with Cerebral Blood Flow in Elderly Subjects Stratified by Cerebrovascular Risk

Bahrani, Ahmed A.; Powell, David K.; Yu, Guoquiang; Johnson, Eleanor S.; Jicha, Gregory A.; Smith, Charles D.

doi:10.1016/j.jstrokecerebrovasdis.2016.10.017

Cited by 55 publications

(63 citation statements)

References 43 publications

(32 reference statements)

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“…Compared to manual results, computed semi‐automatically measured brain volume showed high agreement with an R 2 of 0.93 . This semi‐automated technique was widely used to measure WMH volume in many previous studies .…”

Section: Methodsmentioning

confidence: 71%

Favorable impact of non‐alcoholic fatty liver disease on the cerebral white matter hyperintensity in a neurologically healthy population

Jeong

Kwon

Park

et al. 2019

Euro J of Neurology

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Background and purpose Although non‐alcoholic fatty liver disease (NAFLD) shares common cardiovascular risk factors with cerebral white matter hyperintensity (WMH), few studies have reported the association between NAFLD and WMH. The association between the presence of NAFLD with its severity and the volume of WMH was investigated. Methods This cross‐sectional study was conducted for 2460 subjects who voluntarily participated in health screening check‐ups including brain magnetic resonance imaging and liver ultrasonography at the Health Promotion Center at Seoul National University Hospital from 2009 to 2013. Ultrasonography was used to detect the presence and severity of NAFLD combined with the NAFLD fibrosis score and the FIB‐4 index. The volume of WMH was measured using a semi‐automated quantification method by a trained neurologist. Results The prevalence of NAFLD was 36.5%, and the median volume of WMH in all the subjects was 1.1 ml (interquartile range 0.2–2.7 ml). The presence of NAFLD was associated with a smaller volume of WMH [β (standard error, SE) −0.051 (0.046); P = 0.012]. Moderate to severe NAFLD was associated with a smaller volume of WMH than was non‐NAFLD [β (SE) −0.067 (0.061); P = 0.002]. The negative correlation observed between NAFLD severity and WMH volume was persistent only in those with low FIB‐4 index and low NAFLD fibrosis scores, whereas there was a positive association in those with high FIB‐4 index and NAFLD fibrosis scores. Conclusions Non‐alcoholic fatty liver disease, and its severity, showed a favorable association with WMH volume. However, its causality and mechanism should be evaluated in further relevantly designed studies.

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Section: Methodsmentioning

confidence: 71%

Favorable impact of non‐alcoholic fatty liver disease on the cerebral white matter hyperintensity in a neurologically healthy population

Jeong

Kwon

Park

et al. 2019

Euro J of Neurology

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“…They found two important markers: the first was that deep WMH is associated with decreased regional cortical blood flow, and the second that blood flow in WM shows a greater reduction in the periventricular than in deep WMH areas. The strongest and most consistent risk factors that showed the clearest association with WMH were age, hypertension, hypercholesterolemia, diabetes and smoke [34].…”

Section: Discussionmentioning

confidence: 96%

White Matter Hyperintensity and Vascular Disease from Biological Basis to Clinical Significance

Garofalo¹,

Suri²,

Porcu³

et al. 2020

Preprint

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White matter disease" identifies a series of different conditions and pathological mechanisms: autoimmune, infectious, toxic-metabolic and vascular. Each of these leads to a global impairment of the neural myelination process through the secondary destruction of previously myelinated structures. To date, the imaging spectrum represents an irreplaceable tool to detect these lesions, describe their distribution patterns and stage them over time.This study aims presents a pictorial review of white matter disease, from pathology to imaging spectrum, reporting current main staging systems with greater emphasis to relationship between cerebrovascular disease and white matter hyper-intensity appearance, and the newest advances in this field.Keywords: CT = Computed Tomography; MRI = Magnetic Resonance Imaging; LA = Leukoaraiosis; WMH = white matter hyperintensities; SVD = small vessels disease; PWMH = periventricular white matter hyperintensities; DWMH = deep white matter hyperintensities Preprints (www.preprints.org) | NOT PEER-REVIEWED | Posted: 5 January 2020

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“…In fact, the only current evidence for ASL‐derived perfusion changes in relation to the chronic use of cholesterol medication points, not to decreases, but rather to increases in regional CBF (not in the auditory cortex) in persons at risk for AD (Carlsson et al, ). Moreover, recent work reported that periventricular, but not deep, white matter lesions were associated with regional cortical CBF reductions in elderly subjects at risk for cerebrovascular diseases (Bahrani et al, ).…”

Section: Discussionmentioning

confidence: 99%

Cortical pattern of reduced perfusion in hearing loss revealed by ASL‐MRI

Ponticorvo

Manara

Pfeuffer

et al. 2019

Human Brain Mapping

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Age‐related hearing loss (HL) can be related to brain dysfunction or structural damage and may result in cerebral metabolic/perfusion abnormalities. Arterial spin labeling (ASL) magnetic resonance imaging (MRI) allows investigating noninvasively brain perfusion changes. Pseudocontinuous ASL and T1‐weighted MRI (at 3 T) and neuropsychological testing (Montreal Cognitive Assessment) were performed in 31 HL (age range = 47–77 years, mean age ± SD = 63.4 ± 8.4 years, pure‐tone average [PTA] HL > 50 dB) and 28 normal hearing (NH; age range = 48–78 years, mean age ± SD = 59.7 ± 7.4 years) subjects. Cerebral blood flow (CBF) and gray matter volume (GMV) were analyzed in the cortical volume to assess perfusion and structural group differences. Two HL subjects showing cognitive impairment were excluded from group comparisons. No significant differences in either global or local atrophy were detected between groups but the HL group exhibited significant regional effects of reduced perfusion within the bilateral primary auditory cortex, with maximal CBF difference (−17.2%) in the right lateral Heschl's gyrus. For the whole sample of HL and NH subjects (n = 59 = 31 HL + 28 NH), the regional CBF was correlated positively to the regional GMV (p = 0.020). In HL subjects (n = 31), the regional CBF was correlated negatively to the audiogram steepness (frequency range: 2–4 kHz, right ear: p = 0.022, left ear: p = 0.015). The observed cortical pattern of perfusion reduction suggests that neuronal metabolism can be related to HL before the recognition of brain structural damage. This also illustrates the potential of ASL‐MRI to contribute early functional markers of reduced central processing associated with HL.

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White Matter Hyperintensity Associations with Cerebral Blood Flow in Elderly Subjects Stratified by Cerebrovascular Risk

Cited by 55 publications

References 43 publications

Favorable impact of non‐alcoholic fatty liver disease on the cerebral white matter hyperintensity in a neurologically healthy population

Favorable impact of non‐alcoholic fatty liver disease on the cerebral white matter hyperintensity in a neurologically healthy population

White Matter Hyperintensity and Vascular Disease from Biological Basis to Clinical Significance

Cortical pattern of reduced perfusion in hearing loss revealed by ASL‐MRI

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