White matter hyperintensities-related cortical changes and correlation with mild behavioral impairment

Lu, Yang; Shu, Jun; Yan, Aijuan; Yang, Fuxia; Xu, Ziwei; Wei, Wenshi

doi:10.1016/j.advms.2022.06.002

Cited by 9 publications

(16 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…47 Atrophy in the left anterior insula, left thalamus proper, and right posterior cingulate partially mediated the relationship between WMH volume and MBI-C total score in people with NC with high WMH and MBI. 47 Studies of conversion from MBI to dementia using MRI 12,37 have identified MBI total score and left hippocampal volume as predictors of conversion to MCI or AD using machine learning, 37 and involvement of frontal lobe atrophy in conversion from MBI to dementia, especially behavioral variant FTD (bvFTD). 12 An examination of the relationship between gray matter volume reduction and cognitive impairment in MBI 13 suggested involvement of the temporal lobe, hippocampus, and parahippocampal gyrus in episodic memory and processing speed in MBI.…”

Section: Structural Imagingmentioning

confidence: 88%

“…42 WMH has been found to show a tendency to be involved in the MBI affective dysregulation, impulse dyscontrol, and apathy domains, 42 and high WMH assessed by the Fazekas scale and a lesion segmentation tool has been associated with the MBI-C total score and scores for decreased motivation, affective dysregulation, and impulse dyscontrol. 47 Atrophy in the left anterior insula, left thalamus proper, and right posterior cingulate partially mediated the relationship between WMH volume and MBI-C total score in people with NC with high WMH and MBI. 47 Studies of conversion from MBI to dementia using MRI 12,37 have identified MBI total score and left hippocampal volume as predictors of conversion to MCI or AD using machine learning, 37 and involvement of frontal lobe atrophy in conversion from MBI to dementia, especially behavioral variant FTD (bvFTD).…”

Section: Structural Imagingmentioning

confidence: 88%

“…Lifestyle diseases, such as diabetes mellitus 29 and hyperlipidemia, 30 are also involved in MBI, which suggests that cerebrovascular lesions may affect MBI. Alternatively, WMH might be involved in MBI via brain atrophy 47 …”

Section: Discussionmentioning

confidence: 99%

“…Magnetic resonance imaging (MRI) was performed in 18 studies 2,[11][12][13][14][36][37][38][39][40][41][42][43][44][45][46][47][48] and suggested associations of MBI with atrophy in the temporal lobe, 13,36,40,43,44 hippocampus, 13,41 parahippocampal gyrus, 13,36,39 and entorhinal cortex. 13,41 Atrophy in brain regions related to the salience network (SAN) was associated with MBI in PD.…”

Section: Structural Imagingmentioning

confidence: 99%

“…38 Use of regional network analysis and network hub analysis showed that MBI was linked to brain regions including the left middle frontal gyrus, bilateral precuneus, and right insula, which are associated with the frontoparietal control network (FPCN), default mode network (DMN), and SAN. 43 The left middle frontal gyrus, 44 precuneus, 36,48 and left insula 47 have also been associated with MBI, and three studies 43,44,47 reported involvement of the thalamus in MBI.…”

Section: Structural Imagingmentioning

confidence: 99%

See 4 more Smart Citations

Neuroimaging of mild behavioral impairment: A systematic review

2023

View full text Add to dashboard Cite

There are many neuroimaging studies of mild behavioral impairment (MBI), but the results have been somewhat inconsistent. Moreover, it remains unclear whether MBI is a risk factor or prodromal symptom of dementia. Therefore, a systematic review was conducted to summarize the results of neuroimaging studies of MBI and consider whether MBI is a prodromal symptom of dementia in terms of its neural correlates.A systematic review supported by a JSPS Grant-in-Aid for Scientific Research (C) was conducted using MBI neuroimaging studies identified using PubMed, PsycINFO, CINAHL, and Google Scholar on November 1, 2022. The inclusion criteria were (i) neuroimaging study; (ii) research on human subjects; (iii) papers written in English; and (iv) not a case study, review, book, comments, or abstract only. Joanna Briggs Institute critical appraisal checklists were used to assess the quality of selected studies, and 23 structural and functional imaging studies were ultimately included in the systematic review. The structural studies suggested an association of MBI with atrophy in the hippocampus, parahippocampal gyrus, entorhinal cortex, and temporal lobe, whereas the functional studies indicated involvement of an altered default mode network, frontoparietal control network, and salience network in MBI. A limitation in many studies was the use of region-of-interest analysis. The brain areas detected as neural correlates of MBI are considered to be alterations in the early stage of each dementia. Therefore, MBI may emerge against a background of pathological changes in dementia.

show abstract