White matter hyperintensities in late life depression: a systematic review

Herrmann, Lucie L.; Masurier, Marisa Le; Ebmeier, Klaus P.

doi:10.1136/jnnp.2007.124651

Cited by 402 publications

(341 citation statements)

References 70 publications

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“…29,31 The relationship of white matter hyperintensities with poor treatment response was evaluated in three studies, with a positive correlation in two of them. 20,30,31 Still, recent meta-analyses showed that these lesions are associated with late-onset depression (vs. early-onset) 35 and also with an increased risk of stroke and dementia, 36 supporting the theory of cerebrovascular disease and depression.…”

Section: Discussionmentioning

confidence: 94%

Therapeutic interventions for vascular depression: a systematic review

Brunoni

Benseñor

Alves

2011

Rev. Bras. Psiquiatr.

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Objective: Vascular depression (VaD) hypothesis supports a bidirectional relationship between cerebrovascular risk factors (CRFs) and depression. We examined whether such concept is appropriate for clinical interventions; i.e., whether treating depressive symptoms has an impact on cerebrovascular risk and vice-versa. Method: Systematic review on interventional studies published from October-1997 to April-2010 on MEDLINE and other databases. Search terms were "depressive disorder" (MeSH), "cerebrovascular disorders" (MeSH), and a batch of highly accurate terms to search for experimental and quasi-experimental trials. We used a structured questionnaire to assess the adequacy of the VaD criteria used for vascular, depression, neuroimaging, and neuropsychological features, as well as the main results of each study. Results: Of the 357 retrieved studies, 12 met our eligibility criteria. These studies adequately reported depression criterion, moderately reported neuroimaging and neuropsychological criteria, and showed severe flaws in vascular assessment. Efficacy trials suggested that nimodipine, transcranial magnetic stimulation, carotid stent placement, and citalopram were effective for VaD. Exploratory studies suggested that white-matter hyperintensities and global vascular risk are predictors of poor response. Although the low quality of the studies hinders the findings' generalization, studies of higher validity support the VaD concept for interventions. Conclusion: VaD seems to be a useful concept for clinical interventions; however, further trials should refine CRFs criteria to assess its impact on antidepressant efficacy. ©2011 Elsevier Editora Ltda. All rights reserved. DesCRIpToRs:Major depressive disorder; Cerebrovascular disorders; Depression; Review; Therapeutics. ReVIeW ARTICLe Therapeutic interventions for vascular depression: a systematic review Intervenções terapêuticas para a depressão vascular: uma revisão sistemática ResumoObjetivo: A hipótese da depressão vascular (DV) defende uma correlação bidirecional entre fatores de risco cerebrovasculares e depressão. Nós investigamos se este conceito é apropriado para intervenções clínicas -ou seja, se o tratamento de sintomas depressivos modifica o risco cerebrovascular e vice-versa. Método: Revisão sistemática de estudos intervencionistas publicados entre outubro/1997 e abril/2010 nos bancos de dados MEDLINE e outros. Os unitermos procurados foram "depressive disorder" (MeSH), "cerebrovascular disorders" (MeSH) e um conjunto de termos altamente acurados para procurar por estudos experimentais ou quasi-experimentais. Nós usamos um questionário estruturado para examinar se os critérios de DV usados para depressão, vascular, neuroimagem e neuropsicológicos foram adequados, e os resultados principais de cada estudo. Resultados: De 357 artigos obtidos, 12 foram inclusos. Eles relataram adequadamente o critério de depressão, moderadamente os critérios neuropsicológicos e de neuroimagem e apresentaram erros graves no critério vascular. Estudos de eficác...

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Section: Discussionmentioning

confidence: 94%

Therapeutic interventions for vascular depression: a systematic review

Brunoni

Benseñor

Alves

2011

Rev. Bras. Psiquiatr.

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“…Acredita-se que a hiperintensidade da substância branca cerebral, detectada por ressonância magnética, seja secundária à doença cerebrovascular de pequenos vasos e a alterações neurodegenerativas 46 . Apesar de estudo com autópsia não associar a hiperintensidade da substância branca com envelhecimento patológico 47 , estudos com neuroimagem corroboram a maior prevalência de depressão tardia, comprometimento cognitivo leve, DA, infartos lacunares e menores velocidade psicomotora e flexibilidade cognitiva 21,46,[48][49][50] .…”

Section: Retrogênese Neuropatológicaunclassified

“…Apesar de estudo com autópsia não associar a hiperintensidade da substância branca com envelhecimento patológico 47 , estudos com neuroimagem corroboram a maior prevalência de depressão tardia, comprometimento cognitivo leve, DA, infartos lacunares e menores velocidade psicomotora e flexibilidade cognitiva 21,46,[48][49][50] . A presença de hiperintensidade da substância branca é inversamente proporcional à perfusão cerebral e localiza-se principalmente nas regiões periventriculares e no corpo caloso 32 , sendo o volume dessas alterações estruturais proporcional ao comprometimento cognitivo 48,51 .…”

Section: Retrogênese Neuropatológicaunclassified

Psicomotricidade e retrogênese: considerações sobre o envelhecimento e a doença de Alzheimer

Borges¹,

Aprahamian²,

Radanovic

et al. 2010

Rev. psiquiatr. clín.

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ResumoContexto: A teoria da retrogênese refere-se às mudanças nas habilidades psicomotoras que ocorrem de forma inversa à aquisição do desenvolvimento motor normal. Tais mudanças ocorrem ao longo do processo de envelhecimento e também são ilustradas por mudanças degenerativas ocorridas na doença de Alzheimer (DA). Objetivos: Revisar o conceito de retrogênese no envelhecimento e na DA e discutir os artigos publicados sobre o assunto nos últimos 10 anos. Métodos: Foi realizada uma pesquisa nas bases de dados PubMed (MEDLINE), LILACS, Cochrane e Sci SciELO com as palavras-chave "retrogenesis" (retrogênese), "elderly" (idoso) e "Alzheimer's disease" (doença de Alzheimer). Resultados: A busca bibliográfica resultou em seis artigos, dois dos quais publicados nos primeiros meses de 2009, sendo realizadas análise descritiva e interpretação crítica deles. Foi possível observar que o estudo da retrogênese na velhice tem sido feito fundamentalmente com base na DA, principalmente por meio de revisões bibliográficas e explorações teóricas. Esses trabalhos correlacionam manifestações observadas na DA com determinadas alterações fisiológicas, seguindo o sentido oposto ao do desenvolvimento normal do ser humano. Conclusão: A partir da revisão realizada, destacou-se o modelo da retrogênese funcional que ilustra as alterações involutivas que ocorrem em pacientes acometidos em pacientes com DA. Modelos experimentais utilizando-se de técnicas de ressonância magnética com medidas de anisotropia, identificando alterações de substância branca, têm sido apresentados para testar as hipóteses teóricas da retrogênese. Borges SM, et al. / Rev Psiq Clín. 2010;37(3):131-7Palavras-chave: Retrogênese, idoso, demência, doença de Alzheimer. AbstractBackground: The theory of retrogenesis refers to changes in psychomotor abilities that occur in the reverse order in which they are acquired in normal psychomotor development. Such changes occur along the aging process and are also illustrated by the degenerative changes that occur in Alzheimer's disease (AD). Objectives: To review the concept of retrogenesis in aging and in AD and to discuss the articles published on the subject in the last ten years. Methods: A search was conducted in the databases PubMed (MEDLINE), LILACS, Cochrane and SciELO with the keywords "retrogenesis", "elderly" and "Alzheimer's disease". Results:The literature search resulted in six articles, two of which recently published. We conducted a descriptive analysis of them. We observed that the study of retrogenesis in old age has been done primarily on the basis of AD, mainly through literature reviews and theoretical explorations. These works correlate events observed in AD with some physiological changes, following the opposite direction to the normal development of human beings. Discussion: Based on available literature, we support the notion that functional retrogenesis model illustrate the changes that occur in patients with AD. This notion is supported by experimental models using diffusion tensor imaging and addressing w...

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“…Among various morphological findings distinguishing LOD from EOD, vascular lesions observed in the subcortical structures are the most consistent and robust abnormality reported in LOD. 8,13,14 Herrmann et al 15 conducted a systematic meta-analysis and concluded that LOD is characterized by more frequent and intense white matter changes, with an odds ratio over 4 for LOD compared with EOD. Greater duration of depressive symptoms, signs, and treatment did not appear to have a measurable impact on white matter signals on magnetic resonance imaging (MRI).…”

Section: Introductionmentioning

confidence: 99%

Differentiating early and late‐onset depression with multichannel near‐infrared spectroscopy

et al. 2008

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Background: Individuals with late-life depression can be divided into two categories, those with early and late-onset depression (EOD and LOD, respectively). It has been reported that LOD has more accentuated subcortical vascular lesions and frontal lobe dysfunction (hypofrontality). The aim of the present study was to examine whether LOD exhibits more prominent hypofrontality than EOD during performance of the word fluency task (WFT) under multichannel near-infrared spectroscopy (NIRS), a newly developed non-invasive functional neuroimaging technique. Methods: Eleven patients with EOD, 12 patients with LOD, and 13 healthy controls participated in the study. Clinical symptoms of depression were equivalent in the EOD and LOD groups. Brain magnetic resonance imaging demonstrated more robust subcortical vascular changes in LOD than EOD. The NIRS images were obtained using an ETG-4000, 52-channel NIRS system (Hitachi Medical, Tokyo, Japan). Mean changes in oxy-hemoglobin (oxy-Hb) were evaluated while the participants performed the phonemic WFT. Results: Healthy controls exhibited clear increases in oxy-Hb bilaterally throughout the medial to the lateral frontal cortices and the superior temporal areas during the WFT. In contrast, increases in oxy-Hb were mildly attenuated in EOD and severely attenuated in LOD in most channels. Subsequent analyses revealed that increases in oxy-Hb in LOD during the WFT was significantly poorer than in EOD in the left lateral portion of the cortex, including the dorsolateral prefrontal and the superior temporal areas. In addition, significant negative correlations were obtained between the age of onset and oxy-Hb, as well as between subcortical vascular changes and oxy-Hb in the lateral channels. These findings suggest that the higher the age of onset of depression, and the more prominent the vascular lesions, the greater the attenuation in lateral frontal and temporal activation, as indicated by NIRS. Conclusions: Multichannel NIRS is useful for demonstrating attenuated functional activation in the left lateral prefrontal and temporal areas in LOD and, thus, for differentiating between LOD and EOD. The NIRS findings observed may have useful clinical implications for treatment-resistant LOD.

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White matter hyperintensities in late life depression: a systematic review

Cited by 402 publications

References 70 publications

Therapeutic interventions for vascular depression: a systematic review

Therapeutic interventions for vascular depression: a systematic review

Psicomotricidade e retrogênese: considerações sobre o envelhecimento e a doença de Alzheimer

Differentiating early and late‐onset depression with multichannel near‐infrared spectroscopy

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