White matter hyperintensities in diverse populations: A systematic review of literature in the United States

Farkhondeh, Vista; DeCarli, Charles

doi:10.1016/j.cccb.2024.100204

Cited by 1 publication

(1 citation statement)

References 47 publications

(111 reference statements)

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“…While this comprehensive RNA-seq study highlighted potential drivers of AD WMHs, there are limitations to this work that we hope to address with future studies. For one, given a small sample size and variations in gene expression among samples, a larger population-based cohort including diverse ethnic groups 70 may further substantiate the current findings. Second, our current samples were chosen based on the availability of in vivo MRI data.…”

Section: Discussionmentioning

confidence: 62%

Molecular profiling of frontal and occipital subcortical white matter hyperintensities in Alzheimer’s disease

Malla,

Bryant,

Jayakumar

et al. 2024

Preprint

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White matter hyperintensities (WMHs) are commonly detected on T2-weighted magnetic resonance imaging (MRI) scans, occurring in both typical aging and Alzheimer’s disease. Despite their frequent appearance and their association with cognitive decline, the molecular factors contributing to WMHs remain unclear. In this study, we investigated the transcriptomic profiles of two commonly affected brain regions with coincident AD pathology—frontal subcortical white matter (frontal-WM) and occipital subcortical white matter (occipital-WM)—and compared with age-matched healthy controls. Through RNA-sequencing in frontal- and occipital-WM bulk tissues, we identified an upregulation of genes associated with brain vasculature function in AD white matter. To further elucidate vasculature-specific transcriptomic features, we performed RNA-seq analysis on blood vessels isolated from these white matter regions, which revealed an upregulation of genes related to protein folding pathways. Finally, comparing gene expression profiles between AD individuals with high-versus low-WMH burden showed an increased expression of pathways associated with immune function. Taken together, our study characterizes the diverse molecular profiles of white matter changes in AD compared to normal aging and provides new mechanistic insights processes underlying AD-related WMHs.

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Section: Discussionmentioning

confidence: 62%