White matter fiber density abnormalities in cognitively normal adults at risk for late-onset Alzheimer's disease

Abstract

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Distinct fiber-specific white matter reductions pattern in early- and late-onset Alzheimer’s disease

“…First, higher number of diffusion gradient directions and higher b-values might help to estimate intra-axonal volume fraction and multiple fiber orientations. Although the low b-value should not hold much influence over the FC, and FBA have previously been applied in neurological disorders using diffusion data with lower b-value [ 35 – 38 ] and lower gradient directions as well [ 17 , 20 ]. Based on the results from test-retest analysis, we believe our study showed the possibility of applying advanced diffusion-based techniques to data acquired under clinical settings, which help probe different neurodegenerative processes.…”

“…A recent work showed that FBA could accurately reflect the microstructural differences between AD and healthy elderly, and more importantly, these results are biologically interpretable [ 18 ]. To date, this advanced method has been successfully applied in various neurodegenerative diseases, including AD and Parkinson disease [ 17 , 18 , 20 ].…”

Olfactory, Auditory, and Vestibular Performance: Multisensory Impairment Is Significantly Associated With Incident Cognitive Impairment

“…These are the same anatomic areas through which olfaction is processed. Olfactory identification deficits correlate with atrophy of the hippocampus, olfactory bulb, and entorhinal cortex ( 44 , 45 ). Behavioral and functional data both indicate that activation of the primary olfactory cortex depends on attention ( 46 , 47 ).…”

Oculomotor Abnormalities during Reading in the Offspring of Late-Onset Alzheimer’s Disease

“…As LOAD pathophysiological process begins decades before the first clinical symptoms appear [40], individuals were recruited to participate in a larger, exploratory, crosssectional study with the aim of assessing early neuroimaging, cognitive and circadian markers in asymptomatic, middle-aged O-LOAD, which are believed to be at greater genetic risk of developing LOAD [41,32,42,36,43,44,45,46]. Accompanying family members of LOAD patients were informed of the study and invited to participate by the patients' physicians.…”