White Matter Differences Predict Cognitive Vulnerability to Sleep Deprivation

Rocklage, Matthew D.; Williams, Victoria J.; Pacheco, Jennifer; Schnyer, David M.

doi:10.1093/sleep/32.8.1100

Cited by 52 publications

(36 citation statements)

References 9 publications

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“…Previous studies suggested that specific structural measures taken at rest may reflect the degree of individual cognitive vulnerability to sleep deprivation (Cui et al, 2015; Rocklage et al, 2009). Here, we found that structural changes occurring during extended wake can be used to predict individual vigilance levels, and may partially contribute to predict variation in specific behavioral measures related to performance in an impulse control test.…”

Section: Discussionmentioning

confidence: 99%

Sleep reverts changes in human gray and white matter caused by wake-dependent training

et al. 2016

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Learning leads to rapid microstructural changes in grey (GM) and white (WM) matter. Do these changes continue to accumulate if task training continues, and can they be reverted by sleep? We addressed these questions by combining structural and diffusion weighted MRI and high-density EEG in 16 subjects studied during the physiological sleep/wake cycle, after 12h and 24h of intense practice in two different tasks, and after post-training sleep. Compared to baseline wake, 12h of training led to a decline in cortical mean diffusivity. The decrease became even more significant after 24h of task practice combined with sleep deprivation. Prolonged practice also resulted in decreased ventricular volume and increased GM and WM subcortical volumes. All changes reverted after recovery sleep. Moreover, these structural alterations predicted cognitive performance at the individual level, suggesting that sleep's ability to counteract performance deficits is linked to its effects on the brain microstructure. The cellular mechanisms that account for the structural effects of sleep are unknown, but they may be linked to its role in promoting the production of cerebrospinal fluid and the decrease in synapse size and strength, as well as to its recently discovered ability to enhance the extracellular space and the clearance of brain metabolites.

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Section: Discussionmentioning

confidence: 99%

Sleep reverts changes in human gray and white matter caused by wake-dependent training

et al. 2016

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“…These declines have been proposed to reflect lower thalamo-cortical functional connectivity (Babiloni et al, 2010). Previous research has shown that increased structural brain connectivity moderates the effects of sleep loss on cognition (Rocklage, Williams, Pacheco, & Schnyer, 2009). The present results suggest that changes in daily sleep patterns may also effect functional brain connectivity in ways that are currently not well understood.…”

Section: Discussionmentioning

confidence: 99%

An examination of the association between chronic sleep restriction and electrocortical arousal in college students

Witkowski

Trujillo

Sherman

et al. 2015

Clinical Neurophysiology

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“…While the distribution of reaction times did not deviate from normality, the number of lapses per session followed a Poisson distribution and was accordingly modeled in the linear mixed-effects model. Based on the observation that vulnerability to sleep deprivation varies greatly across people (Van Dongen et al, 2004, 2012; Rocklage et al, 2009), we hypothesized that sleep-deprived participants with the most marked lack of increase in effective connectivity to eye-opening would be the ones to perform worst on the brief-stimulus reaction time task. For each subject, averages over the five post-sleep deprivation sessions were calculated both for the performance measures (reaction times and lapses) and for the relative change (ratio) of GC in the forward direction during the eyes-closed relative to eyes-closed periods.…”

Section: Methodsmentioning

confidence: 99%

“…Vigilance has been proposed as the cognitive process most sensitive to sleep deprivation in adults (Lim and Dinges, 2010) and the culprit of the performance degradation on other tasks (Philibert, 2005; Lim and Dinges, 2008, 2010). Of note, there are considerable trait-like individual differences in the effect of sleep deprivation on vigilance (Van Dongen et al, 2004, 2012; Rocklage et al, 2009). Pursuing the brain mechanisms involved in these individual differences in vulnerability is thus of considerable importance.…”

Section: Introductionmentioning

confidence: 99%

Disrupted directed connectivity along the cingulate cortex determines vigilance after sleep deprivation

et al. 2013

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The cingulate cortex is regarded as the backbone of structural and functional connectivity of the brain. While its functional connectivity has been intensively studied, little is known about its effective connectivity, its modulation by behavioral states, and its involvement in cognitive performance. Given their previously reported effects on cingulate functional connectivity, we investigated how eye-closure and sleep deprivation changed cingulate effective connectivity, estimated from resting-state high-density electroencephalography (EEG) using a novel method to calculate Granger Causality directly in source space. Effective connectivity along the cingulate cortex was dominant in the forward direction. Eyes-open connectivity in the forward direction was greater compared to eyes-closed, in well-rested participants. The difference between eyes-open and eyes-closed connectivity was attenuated and no longer significant after sleep deprivation. Individual variability in the forward connectivity after sleep deprivation predicted subsequent task performance, such that those subjects who showed a greater increase in forward connectivity between the eyes-open and the eyes-closed periods also performed better on a sustained attention task. Effective connectivity in the opposite, backward, direction was not affected by whether the eyes were open or closed or by sleep deprivation. These findings indicate that the effective connectivity from posterior to anterior cingulate regions is enhanced when a well-rested subject has his eyes open compared to when they are closed. Sleep deprivation impairs this directed information flow, proportional to its deleterious effect on vigilance. Therefore, sleep may play a role in the maintenance of waking effective connectivity.

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White Matter Differences Predict Cognitive Vulnerability to Sleep Deprivation

Abstract: Differences in distributed WM pathways reflect, and may contribute to, a person's ability to function effectively when sleep deprived. The widespread nature of this effect supports previous views that TSD has a global effect on brain functioning.

Cited by 52 publications

References 9 publications

Sleep reverts changes in human gray and white matter caused by wake-dependent training

Sleep reverts changes in human gray and white matter caused by wake-dependent training

An examination of the association between chronic sleep restriction and electrocortical arousal in college students

Disrupted directed connectivity along the cingulate cortex determines vigilance after sleep deprivation

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