White matter correlates of scam susceptibility in community-dwelling older adults

Lamar, Melissa; Arfanakis, Konstantinos; Yu, Lei; Zhang, Shengwei; Han, S. Duke; Fleischman, Debra; Bennett, David A.; Boyle, Patricia A.

doi:10.1007/s11682-019-00079-7

Cited by 14 publications

(15 citation statements)

References 40 publications

(83 reference statements)

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“…Findings of medial temporal lobe associations with FE are consistent with previous neuroimaging work from our group on susceptibility to scams (Han et al, 2016b ; Lamar et al, 2019 ). In these studies, the lower structural integrity of the temporal lobes, and particularly the right medial temporal region (Han et al, 2016b ), was associated with increased susceptibility to scams (measured using a six-item questionnaire).…”

Section: Discussionsupporting

confidence: 90%

“…In the present study, we examined whole-brain, voxelwise functional connectivity differences for three regions of interest between a diverse group of cognitively healthy older adults who self-reported a history of FE (FE group) and demographically-matched older adults who denied a history of FE (non-FE group) participating in the Finance, Cognition, and Health in Elders Study (FINCHES). We hypothesized differences in functional connectivity profiles for the medial frontal cortex, hippocampus, and insula between FE and non-FE groups, providing support for existing models implicating decision-making and social cognition in FE risk in older adults (Han et al, 2013 , 2016b ; Spreng et al, 2017 ; Lamar et al, 2019 ).…”

Section: Introductionsupporting

confidence: 64%

“…The medial temporal lobes, including the hippocampus and parahippocampal gyri, have been implicated in studies of risk aversion (Han et al, 2012 ) and temporal discounting (preference for smaller immediate rewards vs. larger delayed rewards; Han et al, 2013 ), possibly reflecting their involvement in prospective imagery (Peters and Buchel, 2011 ). Our group has also found this region to be particularly implicated in studies of susceptibility to scams in older adults (Han et al, 2016b ; Lamar et al, 2019 ). The insular cortex has been cited for its role in interpersonal trust and trust evaluations (Castle et al, 2012 ; Belfi et al, 2015 ), decision making during risk and uncertainty (Singer et al, 2009 ; Mather, 2016 ), and temporal discounting (Wittmann et al, 2010 ).…”

Section: Introductionmentioning

confidence: 73%

“…Decision making also involves prospection, or the representation of future outcomes, to simulate how events will unfold following a decision (Weierich et al, 2011 ). This ability is thought to be more challenging for older adults due to age-related neuropathological changes to brain regions important for prospection, and its decline may negatively impact decision making, increasing susceptibility to scams (Han et al, 2013 , 2016b ; Lamar et al, 2019 ). Finally, evidence suggests that older adults are more trusting of others (Castle et al, 2012 ) and exhibit a positivity bias when forming impressions of others (Cassidy et al, 2013 ).…”

Section: Introductionmentioning

confidence: 99%

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Functional Connectivity Correlates of Perceived Financial Exploitation in Older Adults

Weissberger

Mosqueda

Nguyen

et al. 2020

Front. Aging Neurosci.

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Financial exploitation (FE) in old age is devastating and common; however, the neural correlates of FE are poorly understood. Previous studies of FE in older adults have implicated declines in decision making and social cognition as two risk factors for FE in later life. Here we examined whether functional connectivity among brain regions implicated in decision making and social cognition differed for those with an experience of FE vs. those without. Participants included 16 older adults without cognitive impairment who reported FE (Mean age = 70.5, 62.5% female, Mean education = 16.0 years) and 16 demographically and cognitively matched adults who denied a history of FE (Mean age = 65.1, 37.5% female, Mean education = 15.1 years). Measures of whole-brain resting-state functional connectivity in the hippocampus, insula, and medial frontal cortex were derived for each group. Compared to the non-FE group, FE was associated with greater functional connectivity between the right hippocampus and bilateral temporal regions, and less functional connectivity between the right hippocampus and the right cerebellum and bilateral lingual gyri. The FE group showed less connectivity between the right and left insula and cingulate cortex, and between the right insula and regions of the left lateral temporal gyrus and dorsolateral prefrontal cortex. Finally, the FE group showed greater functional connectivity between the medial frontal cortex and the right lateral temporal gyrus and orbitofrontal cortex, and less functional connectivity with the right pre- and postcentral gyri. Results suggest that perceived FE in old age is associated with whole-brain functional connectivity differences involving the hippocampus, insula, and medial frontal cortex, consistent with models implicating age-associated changes in decision making and social cognition in FE.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionsupporting

confidence: 64%

Section: Introductionmentioning

confidence: 73%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Functional Connectivity Correlates of Perceived Financial Exploitation in Older Adults

Weissberger

Mosqueda

Nguyen

et al. 2020

Front. Aging Neurosci.

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“…Regionconnect and other resources developed in this work have already been applied successfully in healthy young adults as well as other populations. Regionconnect was recently used in voxel-wise investigations involving diffusion tensor imaging data on older adults ( Han et al, 2016 ; 2018 ; Lamar et al, 2019 ), and also in a study of aging with ex-vivo MRI but no diffusion data ( Gaiteri et al, 2019 ). The online interactive version of regionconnect that allows the user to easily select and update a white matter region of interest has been used in education for exploring healthy adult brain connectivity.…”

Section: Discussionmentioning

confidence: 99%

Regionconnect: Rapidly extracting standardized brain connectivity information in voxel-wise neuroimaging studies

Arfanakis

2021

NeuroImage

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Association of Stroke and Cerebrovascular Pathologies With Scam Susceptibility in Older Adults

Kapasi

Schneider

et al. 2023

JAMA Neurol

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ImportanceScam susceptibility is associated with adverse financial and health outcomes, including an increased risk of cognitive decline and dementia. Very little is known about the role of cerebrovascular pathologies with scam susceptibility.ObjectiveTo examine the association of diverse cerebrovascular pathologies (globally and regionally) with scam susceptibility.Design, setting, and ParticipantsThis clinical-pathological cohort study included participants from 2 ongoing studies of aging that began enrollment in 1994 and 1997. In 2010, participants were enrolled in the decision-making and behavioral economics substudy and were followed up for a mean (SD) of 3.4 (2.6) years prior to death. From 1365 older persons with clinical evaluations, 69 were excluded for having dementia at baseline. From 538 older persons who died, 408 had annual assessments for scam susceptibility, cardiovascular risk burden, and cognitive function and consented to brain donation for detailed neuropathologic examination. Data were analyzed from June 2021 through September 2022.ExposuresNeuropathologic examination identified the presence of macroscopic and microscopic infarcts, atherosclerosis, arteriolosclerosis, cerebral amyloid angiopathy, and common neurodegenerative pathologies (Alzheimer disease, limbic-predominant age-related transactive response DNA-binding protein 43 encephalopathy, and Lewy bodies).ResultsThere was a total of 408 participants. The mean (SD) age at death was 91 (6.1) years, the mean (SD) amount of education was 15.6 (3.1) years, and 297 (73%) were women. Participants included 4 Latino individuals (1%), 7 non-Latino Black individuals (2%), and 397 non-Latino White individuals (97%). The frequency of participants with macroscopic infarcts was 38% (n = 154), microinfarcts was 40% (n = 163), and moderate to severe vessel disease; specifically, atherosclerosis was 20% (n = 83), arteriolosclerosis was 25% (n = 100), and cerebral amyloid angiopathy was 35% (n = 143). In linear regression models adjusted for demographics and neurodegenerative pathologies, macroscopic infarcts were associated with greater scam susceptibility (estimate [SE], 0.18 [0.07]; P = .009). This association persisted after adjusting for cardiovascular risk burden and global cognition. Regionally, infarcts localized to the frontal, temporal, and occipital lobes and thalamus were associated with greater scam susceptibility. Neither arteriosclerosis, atherosclerosis, cerebral amyloid angiopathy, nor microinfarcts were associated with scam susceptibility.Conclusions and RelevanceCerebrovascular pathologies, specifically cerebral infarcts, is linked with greater scam susceptibility in older adults, independent of common neurodegenerative diseases such as Alzheimer disease. Future studies examining in vivo magnetic resonance imaging markers of cerebrovascular pathologies with scam susceptibility and related decision-making outcomes will be important.

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White matter correlates of scam susceptibility in community-dwelling older adults

Cited by 14 publications

References 40 publications

Functional Connectivity Correlates of Perceived Financial Exploitation in Older Adults

Functional Connectivity Correlates of Perceived Financial Exploitation in Older Adults

Regionconnect: Rapidly extracting standardized brain connectivity information in voxel-wise neuroimaging studies

Association of Stroke and Cerebrovascular Pathologies With Scam Susceptibility in Older Adults

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