White matter correlates of impulsivity in frontal lobe and their associations with treatment response in first-episode schizophrenia

Jung, Hye-Yeon; Jung, Sra; Bang, Minji; Choi, Tai Kiu; Park, Chun Il; Lee, Sanghyuk

doi:10.1016/j.neulet.2021.136309

Cited by 5 publications

(6 citation statements)

References 40 publications

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“…Several mechanisms have been postulated to explain this association. These include the association of severe positive symptoms with disturbances in inhibitory control functions [ 35 , 73 ] and white matter tracts in the right prefrontal cortex and the right frontal pole that may underlie both dysfunctional impulse control and symptom severity [ 74 ].…”

Section: Discussionmentioning

confidence: 99%

The factor structure of the Barratt Impulsiveness Scale (BIS-11) and correlates of impulsivity among outpatients with schizophrenia and other psychotic disorders in Singapore

et al. 2022

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Background Impulsivity has been linked to risky behaviours amongst patients with schizophrenia or other psychotic disorders. However, there is a dearth of studies examining impulsivity amongst this population in Singapore. Moreover, to date, scales to measure impulsivity have not been validated in this population. The present study seeks to examine the underlying factor structure of the Barratt Impulsiveness Scale (BIS-11) and explore sociodemographic and clinical correlates of impulsivity within this group. Methods Confirmatory factor analyses (CFA) were conducted to test factor structures of the BIS-11 proposed in extant literature. However, due to poor fit statistics, the sample (n = 397) was split into two groups, with Exploratory Factor Analyses (EFA) conducted in the first subgroup (n = 200). The final model of the EFA was then tested within the second subgroup (n = 197) with CFA. Multivariable linear regressions were conducted to examine sociodemographic and clinical correlates of each underlying factor. Results CFA indicated a three-factor structure amongst 16-items of the BIS-11 with acceptable fit: i) Non-planning impulsivity (5-items; α = 0.94), ii) Motor impulsiveness (6-items α = 0.84), and iii) Lack of self-control (5-items, α = 0.85). Lower education was associated with higher non-planning impulsivity. While age, ethnicity, marital status, and general psychiatric symptom severity were significant correlates of motor impulsiveness, problematic alcohol use and general psychiatric symptom severity were related to a greater lack of self-control. Conclusion Factor structures of the BIS-11 suggested by extant literature were not applicable, and we propose an alternative factor structure for BIS-11. Significant correlates of impulsivity are highlighted, and avenues for future research are suggested.

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Section: Discussionmentioning

confidence: 99%

The factor structure of the Barratt Impulsiveness Scale (BIS-11) and correlates of impulsivity among outpatients with schizophrenia and other psychotic disorders in Singapore

et al. 2022

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“…BA10 is associated with complex cognitive functions that depend on maintaining mental representations of alternative courses of action [ 5 ], such as multitasking, prospective memory, time estimation, decision-making, task-switching, and flexible emotional control [ 1 , 5 ]. Accordingly, BA10 abnormalities in SCHIZ and BP have been linked to deficits in working memory [ 11 ], cognitive control [ 14 ], and impulse control [ 15 , 16 ]. BA10 also allows for the integration of internally- and externally obtained cognition [ 1 ], suggesting a potential role in psychotic symptoms, including delusions, hallucinations, and disorganized speech.…”

Section: Introductionmentioning

confidence: 99%

Neurotransmission-related gene expression in the frontal pole is altered in subjects with bipolar disorder and schizophrenia

et al. 2023

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The frontal pole (Brodmann area 10, BA10) is the largest cytoarchitectonic region of the human cortex, performing complex integrative functions. BA10 undergoes intensive adolescent grey matter pruning prior to the age of onset for bipolar disorder (BP) and schizophrenia (SCHIZ), and its dysfunction is likely to underly aspects of their shared symptomology. In this study, we investigated the role of BA10 neurotransmission-related gene expression in BP and SCHIZ. We performed qPCR to measure the expression of 115 neurotransmission-related targets in control, BP, and SCHIZ postmortem samples (n = 72). We chose this method for its high sensitivity to detect low-level expression. We then strengthened our findings by performing a meta-analysis of publicly released BA10 microarray data (n = 101) and identified sources of convergence with our qPCR results. To improve interpretation, we leveraged the unusually large database of clinical metadata accompanying our samples to explore the relationship between BA10 gene expression, therapeutics, substances of abuse, and symptom profiles, and validated these findings with publicly available datasets. Using these convergent sources of evidence, we identified 20 neurotransmission-related genes that were differentially expressed in BP and SCHIZ in BA10. These results included a large diagnosis-related decrease in two important therapeutic targets with low levels of expression, HTR2B and DRD4, as well as other findings related to dopaminergic, GABAergic and astrocytic function. We also observed that therapeutics may produce a differential expression that opposes diagnosis effects. In contrast, substances of abuse showed similar effects on BA10 gene expression as BP and SCHIZ, potentially amplifying diagnosis-related dysregulation.

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“…Those findings may be explained by neuroanatomically dopamine deficiency in the prefrontal cortex. Impulsivity in schizophrenia was found to be associated with white matter tracts in the right dorsolateral prefrontal cortex and the right frontal pole may underlie dysfunctional impulse control [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

“…In a study by Tikàsz et al (2018), involved violent patients with schizophrenia showed that the DLPFC serves as a core region of an anger-related inhibitory cognitive control network [ 18 ]. Another study Jung et al (2022) found that impulse-control difficulties experienced by schizophrenia patients may relate to deteriorated cognitive control function [ 17 ]. Therefore, affection of impulsivity in offspring is also related to emotion processing of anger.…”

Section: Discussionmentioning

confidence: 99%

A study of emotional intelligence in an Egyptian sample of offspring of patients with schizophrenia

ElSehrawy

Elela

Hassan

et al. 2022

Middle East Curr Psychiatry

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Background Emotional intelligence is usually a construct measured in healthy children, now it may be used for relatives of schizophrenia, and considered as trait marker for schizophrenia. Offspring of parents with schizophrenia are considered children with high familial risk for major mental disorder. The aim of the study is to assess emotional intelligence in a group of off springs of a parent with schizophrenia and compare them to healthy control subjects, and to find possible relation between emotional intelligence in offspring and profile of symptoms in schizophrenic parents. Results Offspring of parents with schizophrenia had lower scores of emotional intelligences than their matched controls in emotion perception, self-esteem, low impulsivity and emotion regulation’s subsets of TEIQue-CF. There was correlation between offspring trait emotional intelligence and their parent’s duration of illness. There was no correlation found between schizophrenia severity in the parents and their offspring’s trait emotional intelligence. Conclusions Offspring of parents with schizophrenia had impaired trait emotional intelligence in some of its facets when compared to normal healthy subjects.

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White matter correlates of impulsivity in frontal lobe and their associations with treatment response in first-episode schizophrenia

Cited by 5 publications

References 40 publications

The factor structure of the Barratt Impulsiveness Scale (BIS-11) and correlates of impulsivity among outpatients with schizophrenia and other psychotic disorders in Singapore

The factor structure of the Barratt Impulsiveness Scale (BIS-11) and correlates of impulsivity among outpatients with schizophrenia and other psychotic disorders in Singapore

Neurotransmission-related gene expression in the frontal pole is altered in subjects with bipolar disorder and schizophrenia

A study of emotional intelligence in an Egyptian sample of offspring of patients with schizophrenia

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