White matter correlates of episodic memory encoding and retrieval in schizophrenia

Green, Amity Ella; Croft, Rodney J.; Maller, Jerome Joseph; Fitzgerald, Paul B.

doi:10.1016/j.pscychresns.2016.07.002

Cited by 12 publications

(6 citation statements)

References 90 publications

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“…The posterior parietal cortex is connected to the middle temporal lobe by several WM tracts [36], the degradation of which has been correlated with impairments in episodic memory in cognitively healthy [38] and traumatic brain injury patients [39]. Similar associations regarding posterior WM lesions have also been reported for patients with schizophrenia [40] and MCI [41,42]. Previously, we have examined only frontal and parietal structures, as the reliability of visually rated WM changes in the temporal lobe is considerably lower [43].…”

Section: Discussionmentioning

confidence: 52%

White Matter Hyperintensities and Cognitive Impairment in Healthy and Pathological Aging: A Quantified Brain MRI Study

Kaskikallio

Karrasch

Koikkalainen³

et al. 2019

Dement Geriatr Cogn Disord

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KeywordsWhite matter hyperintensity · Alzheimer dementia · Mild cognitive impairment · Vascular cognitive impairment Abstract Background: Brain changes involving the white matter (WM), often an indication of cerebrovascular pathology, are frequently seen in patients with mild cognitive impairment (MCI) and Alzheimer disease (AD). Few studies have examined possible cognitive domain-or groupspecific cognitive effects of WM pathology in old age, MCI, and AD. Objective: Our purpose was to examine the relationship between WM hyperintensities (WMH), a typical marker for WM pathology, and cognitive functioning in healthy old age and pathological aging using quantified MRI data. Methods: We utilized multidomain neuropsychological data and quantified MRI data from a sample of 42 cognitively healthy older adults and 44 patients with MCI/ AD (total n = 86). Results: After controlling for age and education, WMH in the temporal and parieto-occipital lobes was associated with impairments in processing speed and parietooccipital pathology with verbal memory impairment in the whole sample. Additionally, temporal WMH was associated with impaired processing speed in the patient group specifically. Conclusions: WM pathology is strongly associated with impaired processing speed, and our results indicate that these impairments arise from WMH in the temporal and parieto-occipital regions. In MCI and AD patients with temporal WMH, processing speed impairments are especially prominent. The results of this study increase our knowledge of cognitive repercussions stemming from temporal and/or parieto-occipital WM pathology in healthy and pathological aging.

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Section: Discussionmentioning

confidence: 52%

White Matter Hyperintensities and Cognitive Impairment in Healthy and Pathological Aging: A Quantified Brain MRI Study

Kaskikallio

Karrasch

Koikkalainen³

et al. 2019

Dement Geriatr Cogn Disord

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“…White matter abnormalities are diffuse in subjects with schizophrenia, with globally decreased levels of fractional anisotropy (FA) and increased radial diffusivity (RD) (Chavarria‐Siles et al, ; Reid et al, ), proxy measures for myelin integrity. Deficits are evident diffusely in frontomedial white matter tracts (Drakesmith et al, ), orbitofrontal cortex, posterior parietal cortex (Green et al, ), arcuate fasciculus, cingulum bundle, and inferior longitudinal fasciculus (Oestreich et al, ; Seitz et al, ). The apparently more global disruptions to white matter in schizophrenia compared to other neuropsychiatric disorders are consistent with the more severe and complex nature of dysfunction in schizophrenia.…”

Section: Psychiatric Disordersmentioning

confidence: 99%

Bad wrap: Myelin and myelin plasticity in health and disease

Gibson

Geraghty

Monje

2017

Developmental Neurobiology

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Human central nervous system myelin development extends well into the fourth decade of life, and this protracted period underscores the potential for experience to modulate myelination. The concept of myelin plasticity implies adaptability in myelin structure and function in response to experiences during development and beyond. Mounting evidence supports this concept of neuronal activity-regulated changes in myelin-forming cells, including oligodendrocyte precursor cell proliferation, oligodendrogenesis and modulation of myelin microstructure. In healthy individuals, myelin plasticity in associative white matter structures of the brain is implicated in learning and motor function in both rodents and humans. Activity-dependent changes in myelin-forming cells may influence the function of neural networks that depend on the convergence of numerous neural signals on both a temporal and spatial scale. However, dysregulation of myelin plasticity can disadvantageously alter myelin microstructure and result in aberrant circuit function or contribute to pathological cell proliferation. Emerging roles for myelin plasticity in normal neurological function and in disease are discussed. © 2017 Wiley Periodicals, Inc. Develop Neurobiol 78: 123-135, 2018.

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“…Neurocognitive deficits have been associated with schizophrenia (see Lepage, Bodnar, & Bowie, , for a review), with episodic memory being one of the most impaired domains (Green, Croft, Maller, & Fitzgerald, ; Greenland‐White, Ragland, Niendam, Ferrer, & Carter, ). A subtype of episodic memory is autobiographical memory (AM), which refers to a knowledge base of personal information that includes specific, episodic memories of past events, and more conceptual self‐related information (Conway & Pleydell‐Pearce, ).…”

Section: Introductionmentioning

confidence: 99%

Autobiographical memory specificity across life periods in people with schizophrenia

et al. 2019

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Objective: Because the well-known relationship between autobiographical memory (AM) with social functioning and psychopathology can manifest itself in a different way for memories of different life periods, the current work assesses AM specificity deficits across different life stages in people with schizophrenia. Method: This cross-sectional study compares the performance of specific AM in people with a diagnosis of schizophrenia (n = 53, 78% male, 39.03 mean age) and controls (n = 69, 88% male, 36.65 mean age) for four life periods (childhood, adolescence, early adulthood, and the year preceding the assessment) using the Autobiographical Memory Enquiry. Results: The results revealed worse AM performance in people with schizophrenia, especially for memory of events occurring over the preceding year, and the use of overgeneral memory style for life periods succeeding childhood. Conclusion: These results highlight the need for systematic assessment of difficulties in retrieving specific memories across life periods in people with schizophrenia.

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White matter correlates of episodic memory encoding and retrieval in schizophrenia

Cited by 12 publications

References 90 publications

White Matter Hyperintensities and Cognitive Impairment in Healthy and Pathological Aging: A Quantified Brain MRI Study

White Matter Hyperintensities and Cognitive Impairment in Healthy and Pathological Aging: A Quantified Brain MRI Study

Bad wrap: Myelin and myelin plasticity in health and disease

Autobiographical memory specificity across life periods in people with schizophrenia

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