White Matter Consequences of Retinal Receptor and Ganglion Cell Damage

Ogawa, Shumpei; Takemura, Hiromasa; Horiguchi, Hiroshi; Terao, Masahiko; Haji, Tomoki; Pestilli, Franco; Yeatman, Jason D.; Tsuneoka, Hiroshi; Wandell, Brian A.; Masuda, Yoichiro

doi:10.1167/iovs.14-14737

Cited by 71 publications

(93 citation statements)

References 72 publications

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“…We excluded the first and the last 10 points in order to only include unambiguous white matter and not voxels at the gray/ white matter interface. 54 We then averaged the tract means over all participants within each group and calculated the signed differences between patients and controls for each tract. We focused on effect size to describe the differences between the groups.…”

Section: Discussionmentioning

confidence: 99%

The Structural Properties of Major White Matter Tracts in Strabismic Amblyopia

Duan

Norcia

Yeatman

et al. 2015

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. In order to better understand whether white matter structural deficits are present in strabismic amblyopia, we performed a survey of the tissue properties of 28 major white matter tracts using diffusion and quantitative magnetic resonance imaging approaches.METHODS. We used diffusion-based tensor modeling and a new quantitative T1 protocol to measure fractional anisotropy (FA), mean diffusivity (MD), and myelin-sensitive T1 values. We surveyed tracts in the occipital lobe, including the vertical occipital fasciculus (VOF)-a newly rediscovered tract that bridges dorsal and ventral areas of the occipital lobe, as well as tracts across the rest of the brain. RESULTS.Adults with long-standing strabismic amblyopia show tract-specific elevations in MD. We rank-ordered the tracts on the basis of their MD effect-size. The four most affected tracts were the anterior frontal corpus callosum (ACC), the right VOF, the left inferior longitudinal fasciculus (ILF) and the left optic radiation. CONCLUSIONS.The results suggest that most white matter tissue properties are relatively robust to the early visual insult caused by strabismus. However, strabismic amblyopia does affect MD, not only in occipital tracts, such as the VOF and optic radiation, but also in long range association tracts connecting visual cortex to the frontal and temporal lobes (ILF) and connecting the two hemispheres (ACC).

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Section: Discussionmentioning

confidence: 99%

The Structural Properties of Major White Matter Tracts in Strabismic Amblyopia

Duan

Norcia

Yeatman

et al. 2015

Invest. Ophthalmol. Vis. Sci.

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“…Magnetic resonance imaging (MRI) data acquisition and preprocessing methods used in this study were identical to those developed for (Ogawa et al 2014). Below, we briefly describe the major details of MRI measurements and analyses.…”

Section: Magnetic Resonance Image Data Acquisitionmentioning

confidence: 99%

“…We used a probabilistic anatomical atlas to estimate the location of primary visual cortex (Bruce Fischl 2012;Fischl et al 2007;Hinds et al 2008). The approximate location of the lateral geniculate nucleus (LGN) was estimated manually on the high-resolution anatomical image (Ogawa et al 2014;Allen et al 2015;Millington et al 2014). …”

Section: Brain Segmentation and Regions Of Interest Definitionmentioning

confidence: 99%

“…All methods were reported in previous publications (Sherbondy et al 2008;Ogawa et al 2014). Diffusion properties (Fractional Anisotropy, FA; Mean Diffusivity, MD; Radial Diffusivity, RD; Axial Diffusivity, AD) were calculated separately at 100 locations along the length of the OT and OR, these measurements hereafter are referred to as tract profiles (Yeatman et al 2012;Rykhlevskaia et al 2009).…”

Section: Anatomy Of White Matter Tracts and Relation To Ophthalmic Exmentioning

confidence: 99%

“…For example, the human white matter is affected during normal aging as well as in age-related diseases, such as Alzheimer's or progressive cognitive degeneration (Mayda et al 2010;Wang et al 2010Wang et al , 2012Yeatman et al 2014; Thomason and Thompson 2011). The visual white matter pathways have been also shown to be affected by visual and eye disease, for example, developmental prosopagnosia (Gomez et al 2015;Thomas et al 2008), amblyopia (Allen et al 2015(Allen et al , 2018Duan et al 2015), and retinal ganglion cell damage (Ogawa et al 2014) have all been reported to affect properties of the human white matter, please see Ariel Rokem et al 2017;Millington et al 2014 for reviews. Evidence from in vivo studies suggest that macular degeneration also affects volume of the human primary visual cortex and the visual pathways (Prins et al 2016a, b;Hernowo et al 2014;Malania et al 2017).…”

Section: Introductionmentioning

confidence: 99%

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Age-related macular degeneration affects the optic radiation white matter projecting to locations of retinal damage

et al. 2018

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We investigated the impact of age-related macular degeneration (AMD) on visual acuity and the visual white matter. We combined an adaptive cortical atlas and diffusion-weighted magnetic resonance imaging (dMRI) and tractography to separate optic radiation (OR) projections to different retinal eccentricities in human primary visual cortex. We exploited the known anatomical organization of the OR and clinically relevant data to segment the OR into three primary components projecting to fovea, mid-and far-periphery. We measured white matter tissue properties-fractional anisotropy, linearity, planarity, sphericity-along the aforementioned three components of the optic radiation to compare AMD patients and controls. We found differences in white matter properties specific to OR white matter fascicles projecting to primary visual cortex locations corresponding to the location of retinal damage (fovea). Additionally, we show that the magnitude of white matter properties in AMD patients' correlates with visual acuity. In sum, we demonstrate a specific relation between visual loss, anatomical location of retinal damage and white matter damage in AMD patients. Importantly, we demonstrate that these changes are so profound that can be detected using magnetic resonance imaging data with clinical resolution. The conserved mapping between retinal and white matter damage suggests that retinal neurodegeneration might be a primary cause of white matter degeneration in AMD patients. The results highlight the impact of eye disease on brain tissue, a process that may become an important target to monitor during the course of treatment.

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Selective reduction of fMRI responses to transient achromatic stimuli in the magnocellular layers of the LGN and the superficial layer of the SC of early glaucoma patients

Zhang

Wen

Sun

et al. 2015

Human Brain Mapping

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Glaucoma is now viewed not just a disease of the eye but also a disease of the brain. The prognosis of glaucoma critically depends on how early the disease can be detected. However, early glaucomatous loss of the laminar functions in the human lateral geniculate nucleus (LGN) and superior colliculus (SC) remains difficult to detect and poorly understood. Using functional MRI, we measured neural signals from different layers of the LGN and SC, as well as from the early visual cortices (V1, V2 and MT), in patients with early-stage glaucoma and normal controls. Compared to normal controls, early glaucoma patients showed more reduction of response to transient achromatic stimuli than to sustained chromatic stimuli in the magnocellular layers of the LGN, as well as in the superficial layer of the SC. Magnocellular responses in the LGN were also significantly correlated with the degree of behavioral deficits to the glaucomatous eye. Finally, early glaucoma patients showed no reduction of fMRI response in the early visual cortex. These findings demonstrate that 'large cells' in the human LGN and SC suffer selective loss of response to transient achromatic stimuli at the early stage of glaucoma. Hum Brain Mapp 37:558-569, 2016. © 2015 Wiley Periodicals, Inc.

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White Matter Consequences of Retinal Receptor and Ganglion Cell Damage

Cited by 71 publications

References 72 publications

The Structural Properties of Major White Matter Tracts in Strabismic Amblyopia

The Structural Properties of Major White Matter Tracts in Strabismic Amblyopia

Age-related macular degeneration affects the optic radiation white matter projecting to locations of retinal damage

Selective reduction of fMRI responses to transient achromatic stimuli in the magnocellular layers of the LGN and the superficial layer of the SC of early glaucoma patients

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