White matter changes in dementia with Lewy bodies and Alzheimer’s disease: A tractography-based study

Kiuchi, Kuniaki; Morikawa, Masayuki; Taoka, Toshiaki; Kitamura, Soichiro; Nagashima, Tomohisa; Makinodan, Manabu; Nakagawa, Keiju; Fukusumi, Masami; Ikeshita, Katsumi; Inoue, Makoto; Kichikawa, Kimihiko; Kishimoto, Toshifumi

doi:10.1016/j.jpsychires.2011.01.011

Cited by 42 publications

(36 citation statements)

References 45 publications

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“…Reduced FA in the occipital WM, specifically in the inferior longitudinal fasciculus, a pathway important for visuo-spatial processing, was a common finding in DLB patients (Bozzali et al, 2005; Kantarci et al, 2010; Kiuchi et al, 2011; Lee et al, 2010; Ota et al, 2008; Watson et al, 2012). Many DLB patients who fulfill the clinical criteria for probable DLB have overlapping Alzheimer's disease (AD)–related pathology, which may have contributed to the variation in WM diffusivity alterations in DLB.…”

Section: Introductionmentioning

confidence: 94%

“…DTI studies in dementia with Lewy bodies (DLB) have reported varying extents of white matter (WM) involvement, ranging from wide-spread reduced FA in the corpus callosum, frontal, parietal, occipital and temporal WM (Bozzali et al, 2005; Lee et al, 2010), to involvement confined to temporo-parietal limbic and occipital pathways (Firbank et al, 2007; Firbank et al, 2011; Kiuchi et al, 2011; Watson et al, 2012). Reduced FA in the occipital WM, specifically in the inferior longitudinal fasciculus, a pathway important for visuo-spatial processing, was a common finding in DLB patients (Bozzali et al, 2005; Kantarci et al, 2010; Kiuchi et al, 2011; Lee et al, 2010; Ota et al, 2008; Watson et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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White matter integrity in dementia with Lewy bodies: a voxel-based analysis of diffusion tensor imaging

Nedelská

Schwarz

Boeve

et al. 2015

Neurobiology of Aging

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Many patients with dementia with Lewy bodies have overlapping Alzheimer's disease (AD)–related pathology, which may contribute to white matter (WM) diffusivity alterations on diffusion tensor imaging (DTI). Consecutive patients with DLB (n=30), age and sex matched AD patients (n=30), and cognitively normal controls (CN; n=60) were recruited. All subjects underwent DTI, 18F 2-fluoro-deoxy-d-glucose (FDG) and 11C Pittsburgh compound B (PiB) PET scans. DLB patients had reduced fractional anisotropy (FA) in the parieto-occipital WM but not elsewhere compared to CN, and elevated FA in parahippocampal WM compared to AD patients, which persisted after controlling for Aβ load in DLB. The pattern of WM FA alterations on DTI was consistent with the more diffuse posterior parietal and occipital glucose hypometabolism of FDG PET in the cortex. DLB is characterized by a loss of parieto-occipital WM integrity, independent of concomitant AD-related Aβ load. Cortical glucose hypometabolism accompanies WM FA alterations with a concordant pattern of gray and white matter involvement in the parieto-occipital lobes in DLB.

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Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

White matter integrity in dementia with Lewy bodies: a voxel-based analysis of diffusion tensor imaging

Nedelská

Schwarz

Boeve

et al. 2015

Neurobiology of Aging

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“…Furthermore, some studies reported that AD patients showed reduced FA in the different portions of CB, including the descending cingulum [38], posterior cingulum [39], and anterior cingulum [40]. Other studies found significant FA reductions in the left [36], right [41], or bilateral UF [42] in AD patients. These discrepancies probably result from the heterogeneity of the study population (e.g., different sample sizes, severities of WMH, and stages of AD) and different postprocessing methods.…”

Section: Discussionmentioning

confidence: 99%

Impaired Frontolimbic Connectivity and Depressive Symptoms in Patients with Alzheimer's Disease

Zhu

Miao²,

Bi³

et al. 2016

Dement Geriatr Cogn Disord

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Background/Aims: Depressive symptoms are commonly observed in Alzheimer's disease (AD). The underlying mechanisms of depressive symptoms in AD remain unclear; frontolimbic circuitry dysfunction may play a role. We aimed to investigate the microstructural integrity of frontolimbic connectivity of specific fiber tracts in AD patients with and without depressive symptoms using diffusion tensor imaging (DTI). Methods: Eleven AD patients with depressive symptoms (dep-AD), 18 AD patients without depressive symptoms (nondep-AD), and 18 normal control (NC) subjects were included. The cingulum bundle (CB), uncinate fasciculus (UF), and fornix, mainly frontolimbic connectivity, were measured by DTI tractography and the metrics of fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity, and radial diffusivity (RD) were calculated. Results: Compared with NC subjects, both dep-AD and nondep-AD patients showed significant differences for all indices in the fornix and significantly decreased FA and increased MD and RD in the bilateral CB and UF. When compared to nondep-AD patients, dep-AD patients showed significantly increased MD and RD in the bilateral CB and right UF. Conclusion: Depressive symptoms in AD patients may be involved in greater microstructural abnormalities of frontolimbic connectivity and myelin injury in the bilateral CB and right UF might contribute to the pathophysiology of depressive symptoms in AD.

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“…Possible pathophysiology may be conduction disturbances along pathway I and other pathways (Court et al, 2001;Kiuchi et al, 2011;Ota et al, 2009;Reid, Sabbagh, Corey-Bloom, Tiraboschi, & Thal, 2000;Sanchez-Castaneda et al, 2010).…”

Section: Pathophysiological Bases Related To the Working Hypothesismentioning

confidence: 99%

Computational model of visual hallucination in dementia with Lewy bodies

et al. 2015

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White matter changes in dementia with Lewy bodies and Alzheimer’s disease: A tractography-based study

Cited by 42 publications

References 45 publications

White matter integrity in dementia with Lewy bodies: a voxel-based analysis of diffusion tensor imaging

White matter integrity in dementia with Lewy bodies: a voxel-based analysis of diffusion tensor imaging

Impaired Frontolimbic Connectivity and Depressive Symptoms in Patients with Alzheimer's Disease

Computational model of visual hallucination in dementia with Lewy bodies

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