White matter anatomy of the human deep brain revisited with high resolution DTI fibre tracking

Lemaire, Jean‐Jacques; Cosnard, Guy; Sakka, Laurent; Nuti, C.; Mori, Susumu; Hermoye, Laurent

doi:10.1016/j.neuchi.2011.04.001

Cited by 26 publications

(28 citation statements)

References 27 publications

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“…[37] (contacts were within the associative and sensorimotor parts), as it is very likely that corticosubcorticothalamic loops are modulated directly by contacts within or at the boundary of the STN or indirectly by outside contacts placed on corticosubthalamic white matter fibers crossing the zona incerta below the thalamus. [19] Our results add support to the functional segregation proposed by Yelnik et al . [38] because most contacts were located superiorly, posteriorly, and laterally relative to STN.…”

Section: Discussionsupporting

confidence: 91%

Subthalamus stimulation in Parkinson disease: Accounting for the bilaterality of contacts

Lemaire¹,

Pereira²,

Derost³

et al. 2016

Surg Neurol Int

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Background:Deep brain stimulation (DBS) in Parkinson's disease uses bi-hemispheric high-frequency stimulation within the subthalamus, however, the specific impacts of bilaterality of DBS are still not clear. Thus, we aimed to study the individual-level clinical impact of locations of right-left contact pair-up accounting for each subthalamic nucleus (STN) anatomy.Methods:Contact locations and effects at 1 year were studied retrospectively in an unselected series of 53 patients operated between 2004 and 2010. Location of contacts was defined relatively to the main axis of STN used to map longitudinal and transversal positions, and STN membership (out meaning out-of-STN). Contact pairings were described via three methods: (i) Unified contact location (UCL) collapsing DBS into an all-in-one contact; (ii) balance of contact pair-up (BCPU), defined as symmetric or asymmetric regardless of laterality; (iii) hemisphere-wise most frequent contact pair-up (MFCP) regardless of BCPU. Clinical data were: mean levodopa equivalent dose, Unified Parkinson's Disease Rating Scale (UPDRS) motor score III without medication, UPDRS II and III speech sub-scores, UPDRS II freezing sub-score, 1 year versus preoperative values, with and without levodopa. Ad-hoc two-sided tests were used for statistical analysis.Results:Worsening speech, was more frequent for UCL_out patients and when the left MFCP contact was rear and/or superolateral, however, it less frequent for BCPU-asymmetric patients. Worsening freezing was more frequent when the right MFCP contact was rear and superolateral.Conclusions:These results point to strategies for minimizing dysarthria and freezing as adverse effects of DBS.

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Section: Discussionsupporting

confidence: 91%

Subthalamus stimulation in Parkinson disease: Accounting for the bilaterality of contacts

Lemaire¹,

Pereira²,

Derost³

et al. 2016

Surg Neurol Int

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“…In rodents, lactate, valine, and ascorbate, measures indicative of hypoxia, specific neurochemical changes, and oxidative stress, respectively are acutely increased following TBI and may reflect pathological mechanism (Harris et al, 2012). These metabolites need further verification in human TBI patients (Lemaire et al, 2011). Recent evidence indicates that the lactate/pyruvate ratio is predictive of sleep fragmentation following TBI using mass spectroscopy.…”

Section: Mechanistic Consequences Of Sleep Disruptionmentioning

confidence: 99%

Sleep disruption and the sequelae associated with traumatic brain injury

Lucke‐Wold

Smith

Nguyen

et al. 2015

Neuroscience & Biobehavioral Reviews

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Sleep disruption, which includes a loss of sleep as well as poor quality fragmented sleep, frequently follows traumatic brain injury (TBI) impacting a large number of patients each year in the United States. Fragmented and/or disrupted sleep can worsen neuropsychiatric, behavioral, and physical symptoms of TBI. Additionally, sleep disruption impairs recovery and can lead to cognitive decline. The most common sleep disruption following TBI is insomnia, which is difficulty staying asleep. The consequences of disrupted sleep following injury range from deranged metabolomics and blood brain barrier compromise to altered neuroplasticity and degeneration. There are several theories for why sleep is necessary (e.g., glymphatic clearance and metabolic regulation) and these may help explain how sleep disruption contributes to degeneration within the brain. Experimental data indicate disrupted sleep allows hyperphosphorylated tau and amyloid β plaques to accumulate. As sleep disruption may act as a cellular stressor, target areas warranting further scientific investigation include the increase in endoplasmic reticulum and oxidative stress following acute periods of sleep deprivation. Potential treatment options for restoring the normal sleep cycle include melatonin derivatives and cognitive behavioral therapy.

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“…It can identify the location of this activation with an accuracy level comparable to PET and fMRI [22]. Besides, the Diffusion Tensor Imaging (DTI) is a special MRI technique which can potentially be used to assess the anatomy of white matter (WM) and its connectivity in vivo [23]. …”

Section: The Commonly Used Neuroimaging Techniques In Acupuncture mentioning

confidence: 99%

Connectomics: A New Direction in Research to Understand the Mechanism of Acupuncture

Sun

Yang

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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Acupuncture has been used to treat various disorders in China and some other eastern countries for thousands of years. Nowadays, acupuncture is gradually accepted as an alternative and complementary method in western countries for its undeniable therapeutic effects. However, its central mechanism is still unclear. It is especially difficult to reveal how different regions in the brain influence one another and how the relationship is among these regions responding to acupuncture treatment. Recently, by applying neuroimaging techniques and network theory, acupuncture studies can make further efforts to investigate the influence of acupuncture on regional cerebral functional connectivity (FC) and the modulation on “acupuncture-related” networks. Connectomics appears to be a new direction in research to further understand the central mechanism underlying acupuncture. In this paper, an overview of connectomics application in acupuncture research will be discussed, with special emphasis on present findings of acupuncture and its influence on cerebral FC. Firstly, the connectomics concept and its significance on acupuncture will be outlined. Secondly, the commonly used brain imaging techniques will be briefly introduced. Thirdly, the influence of acupuncture on FC will be discussed in greater detail. Finally, the possible direction in forthcoming research will be reviewed by analyzing the limitation of present studies.

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White matter anatomy of the human deep brain revisited with high resolution DTI fibre tracking

Abstract: Beyond to demonstrate the feasibility of imaging the deepest WM fascicles in vivo, our results pave the way for a better understanding of the brain connectivity and for developing targeted neuromodulation.

Cited by 26 publications

References 27 publications

Subthalamus stimulation in Parkinson disease: Accounting for the bilaterality of contacts

Subthalamus stimulation in Parkinson disease: Accounting for the bilaterality of contacts

Sleep disruption and the sequelae associated with traumatic brain injury

Connectomics: A New Direction in Research to Understand the Mechanism of Acupuncture

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