White Matter Abnormalities in Spontaneous Subarachnoid Hemorrhage

Abstract

Background and Purpose: We investigated white matter abnormalities in patients with spontaneous subarachnoid hemorrhage following aneurysmal rupture, by using tract-based spatial statistics. Methods: Sixteen patients with spontaneous subarachnoid hemorrhage due to aneurysmal rupture and 18 age- and sex-matched healthy control subjects were recruited. Voxel-wise statistical analysis of fractional anisotropy data was performed by using tract-based spatial statistics as implemented in the Functional Magnetic Resonance Imaging of the Brain Software Library. We calculated mean fractional anisotropy values across the tract skeleton and within 48 regions of interest based on the intersections between the fractional anisotropy skeleton and the probabilistic Johns Hopkins University white matter atlases. Results: Comparing the patient and control groups, the fractional anisotropy values of 44 regions of interest among the 48 regions of interest showed significant differences ( P <0.05). However, significant differences were not observed in the remaining 4 regions of interest (both retrolenticular parts of the internal capsule, the right superior longitudinal fasciculus, and the right superior corona radiata; P >0.05). Conclusions: By undertaking tract-based spatial statistics analysis, we detected wide-ranging white matter abnormalities in patients with spontaneous subarachnoid hemorrhage. REGISTRATION: URL: http://www.e-irb.com/index.jsp . Unique identifier: 2019-06-032.

White Matter Abnormalities in Traumatic Subarachnoid Hemorrhage: A Tract-Based Spatial Statistics Study

“…By using DTI, many studies have reported SAH-related neural tract injuries [ 36 , 43 – 55 ]. However, few studies have assessed the influence of SAH on the entire brain white matter, and recently, Jang et al (2020), by applying TBSS, demonstrated that spontaneous SAH following aneurysmal rupture can induce abnormalities in extensive areas of the subcortical white matter [ 36 ]. However, the majority of these previous studies are related to spontaneous aneurysmal SAH, and little has been reported on the neural injuries associated with traumatic SAH.…”

“…DTI data were obtained at an average of 12.43±12.36 months after SAH onset by using a 1.5 T Philips Gyroscan Intera device (Hoffman-LaRoche, Best, Netherlands) with 32 non-collinear diffusion-sensitizing gradients by performing single-shot echo-planar imaging. For the 32 non-collinear diffusion-sensitizing gradients, 65 consecutive slices were obtained parallel to the anterior commissure – posterior commissure line [ 36 ]. Imaging parameters were as follows: acquisition matrix=96×96, reconstructed to matrix=192×192 matrix, field of view=240×240 mm, repetition time=10,398 ms, echo time=72 ms, echo-planning imaging factor=59 and b =1000 s/mm 2 , slice gap=0, and slice thickness=2.5 mm [ 36 ].…”

“…For the 32 non-collinear diffusion-sensitizing gradients, 65 consecutive slices were obtained parallel to the anterior commissure – posterior commissure line [ 36 ]. Imaging parameters were as follows: acquisition matrix=96×96, reconstructed to matrix=192×192 matrix, field of view=240×240 mm, repetition time=10,398 ms, echo time=72 ms, echo-planning imaging factor=59 and b =1000 s/mm 2 , slice gap=0, and slice thickness=2.5 mm [ 36 ]. Analysis of diffusion-weighted imaging data was conducted through the Oxford Centre for Functional Magnetic Resonance Imaging of the Brain (FMRIB) Software Library ( www.fmrib.ox.ac.uk/fsl ).…”

Injury of the Corticofugal Tract from the Secondary Motor Area in Middle Cerebral Territory Infarction: A DTI Study

“…For each of the 32 non-collinear diffusion-sensitizing gradients, 65 contiguous slices were acquired parallel to the anterior or posterior commissure line. 27 The imaging parameters were as The Oxford Centre for Functional Magnetic Resonance Imaging of the Brain Software Library (FSL; www.fmrib.ox.ac.uk/fsl) (FSL version 5.0, FMRIB, Oxford, UK) was used to analyze the diffusion-weighted imaging data. Affine multiscale two-dimensional registration was applied to correct the head motion effect and image distortion due to eddy currents.…”

Secondary White Matter Injury and Therapeutic Targets After Subarachnoid Hemorrhage

“…Therefore, the study of white matter injury after SAH may be of more importance than we currently know. Lee et al found extensive white matter abnormalities in SAH patients through tract-based spatial statistical analysis, but not in retrolenticular parts of the internal capsule, right superior longitudinal fasciculus, or right superior corona radiata (10), providing important data support for the accurate diagnosis of the presence and severity of nerve injury in patients with subarachnoid hemorrhage. Clinical studies did find different types of white matter lesions in SAH patients.…”