White matter abnormalities in bipolar disorder and schizophrenia detected using diffusion tensor magnetic resonance imaging

Sussmann, Jessika E.; Lymer, Katherine; McKirdy, James; Moorhead, William J.; Maniega, S. Munoz; Job, Dominic; Hall, Jérémy; Johnstone, Eve C.; Lawrie, Stephen M.; McIntosh, Andrew

doi:10.1016/j.schres.2007.12.007

Cited by 45 publications

(70 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…5 DTI studies of patients with schizophrenia and bipolar disorder have generally confirmed the results from T 1 -weighted MRI. 6 Deficits in the ALIC and frontal white matter have been confirmed in both schizophrenia and bipolar disorder by studying patients within the same study, 7 supporting the idea that these deficits may be related to the shared pathophysiology of both conditions. These deficits are also found in individuals at high risk of schizophrenia for genetic reasons, 8 suggesting that they are likely to be associated with genetic factors potentially related to the aetiology of psychosis.…”

Section: Introductionmentioning

confidence: 65%

The effects of a neuregulin 1 variant on white matter density and integrity

et al. 2007

View full text Add to dashboard Cite

Theories of abnormal anatomical and functional connectivity in schizophrenia and bipolar disorder are supported by evidence from functional magnetic resonance imaging (MRI), structural MRI and diffusion tensor imaging (DTI). The presence of similar abnormalities in unaffected relatives suggests such disconnectivity is genetically mediated, albeit through unspecified loci. Neuregulin 1 (NRG1) is a psychosis susceptibility gene with effects on neuronal migration, axon guidance and myelination that could potentially explain these findings. In the current study, unaffected subjects were genotyped at the NRG1 single nucleotide polymorphism (SNP) rs6994992 (SNP8NRG243177) locus, previously associated with increased risk for psychosis, and the effect of genetic variation at this locus on white matter density (T 1 -weighted MRI) and integrity (DTI) was ascertained. Subjects with the riskassociated TT genotype had reduced white matter density in the anterior limb of the internal capsule and evidence of reduced structural connectivity in the same region using DTI. We therefore provide the first imaging evidence that genetic variation in NRG1 is associated with reduced white matter density and integrity in human subjects. This finding is discussed in the context of NRG1 effects on neuronal migration, axon guidance and myelination.

show abstract

Section: Introductionmentioning

confidence: 65%

The effects of a neuregulin 1 variant on white matter density and integrity

et al. 2007

View full text Add to dashboard Cite

show abstract

“…This is not the first study pointing to altered diffusion parameters in the thalamus or thalamocortical pathways. DTI findings supporting altered integrity of thalamocortical connectivity in schizophrenia include controversial alterations of fractional anisotropy in the anterior limb of the internal capsule (ALIC) Kubicki et al, 2005;Mamah et al, 2010;Sprooten et al, 2009;Sussmann et al, 2009;Zhang et al, 2010;Zhou et al, 2008, but see Ashtari et al, 2007;Kito et al, 2009;Kyriakopoulos et al, 2008;Szeszko et al, 2005;White et al, 2007 for negative findings in younger individuals and Beasley et al, 2009 for lack of evidence of myelin abnormalities post-mortem), of the tracts connecting to the LPFC (Kim et al, 2008;Oh et al, 2009) and altered FA (Hashimoto et al, 2009) or mean diffusivity in the thalamus itself (Agarwal et al, 2008;Rose et al, 2006;Spoletini et al, 2011). Kim et al (2007) have performed a similar DTI study, with an identical a-priori hypothesis, but found only differences in the thalamic CDR defined by connectivity to the orbitofrontal, parietal, and medial prefrontal cortices.…”

Section: Discussionmentioning

confidence: 99%

Investigation of Anatomical Thalamo-Cortical Connectivity and fMRI Activation in Schizophrenia

Marenco

Stein

Savostyanova

et al. 2011

Neuropsychopharmacol

142

101

View full text Add to dashboard Cite

The purpose of this study was to examine measures of anatomical connectivity between the thalamus and lateral prefrontal cortex (LPFC) in schizophrenia and to assess their functional implications. We measured thalamocortical connectivity with diffusion tensor imaging (DTI) and probabilistic tractography in 15 patients with schizophrenia and 22 age-and sex-matched controls. The relationship between thalamocortical connectivity and prefrontal cortical blood-oxygenation-level-dependent (BOLD) functional activity as well as behavioral performance during working memory was examined in a subsample of 9 patients and 18 controls. Compared with controls, schizophrenia patients showed reduced total connectivity of the thalamus to only one of six cortical regions, the LPFC. The size of the thalamic region with at least 25% of model fibers reaching the LPFC was also reduced in patients compared with controls. The total thalamocortical connectivity to the LPFC predicted working memory task performance and also correlated with LPFC BOLD activation. Notably, the correlation with BOLD activation was accentuated in patients as compared with controls in the ventral LPFC. These results suggest that thalamocortical connectivity to the LPFC is altered in schizophrenia with functional consequences on working memory processing in LPFC.

show abstract

“…In schizophrenia, diffusion MRI studies have shown significant decrease in FA in multiple WM fiber bundles relative to healthy controls using whole brain (Mori et al, 2007b;Rotarska-Jagiela et al, 2009;Schlosser et al, 2007;Shergill et al, 2007;Sussmann et al, 2009), restricted voxelbased (Douaud et al, 2007;Karlsgodt et al, 2008;Lim et al, 1999) and reconstructed tract-based (McIntosh et al, 2008;Phillips et al, 2009;Whitford et al, 2010) analysis methods. Longitudinal studies highlight the progressive nature of these deficits.…”

Section: Introductionmentioning

confidence: 99%

“…The most consistently implicated WM bundles in chronic schizophrenia samples include the genu of the corpus callosum (Kong et al, 2011;Kubicki et al, 2008;RotarskaJagiela et al, 2008;Whitford et al, 2010), the splenium of the corpus callosum (Agartz et al, 2001;Foong et al, 2000), anterior cingulate (Camchong et al, 2011;Sun et al, 2003;Wang et al, 2004), and anterior limb of the internal capsule (ALIC) (Buchsbaum et al, 1998;Sussmann et al, 2009). However, none of these studies were specifically carried out on a treatment-resistant clozapine-naive group, and clozapine has previously been reported to cause structural changes in the brain (Ho et al, 2003;Molina et al, 2005;Scheepers et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Altered Interhemispheric and Temporal Lobe White Matter Microstructural Organization in Severe Chronic Schizophrenia

Holleran

Ahmed

Anderson‐Schmidt

et al. 2013

Neuropsychopharmacol

View full text Add to dashboard Cite

Diffusion MRI investigations in schizophrenia provide evidence of abnormal white matter (WM) microstructural organization as indicated by reduced fractional anisotropy (FA) primarily in interhemispheric, left frontal and temporal WM. Using tract-based spatial statistics (TBSS), we examined diffusion parameters in a sample of patients with severe chronic schizophrenia. Diffusion MRI data were acquired on 19 patients with chronic severe schizophrenia and 19 age-and gender-matched healthy controls using a 64 gradient direction sequence, (b ¼ 1300 s/mm 2 ) collected on a Siemens 1.5T MRI scanner. Diagnosis of schizophrenia was determined by Diagnostic and Statistical Manual for Mental Disorders 4th Edition (DSM-IV) Structured Clinical Interview for DSM disorder (SCID). Patients were treatment resistance, having failed to respond to at least two antipsychotic medications, and had prolonged periods of moderate to severe positive or negative symptoms. Analysis of diffusion parameters was carried out using TBSS. Individuals with chronic severe schizophrenia had significantly reduced FA with corresponding increased radial diffusivity in the genu, body, and splenium of the corpus callosum, the right posterior limb of the internal capsule, right external capsule, and the right temporal inferior longitudinal fasciculus. There were no voxels of significantly increased FA in patients compared with controls. A decrease in splenium FA was shown to be related to a longer illness duration. We detected widespread abnormal diffusivity properties in the callosal and temporal lobe WM regions in individuals with severe chronic schizophrenia who have not previously been exposed to clozapine. These deficits can be driven by a number of factors that are indistinguishable using in vivo diffusion-weighted imaging, but may be related to reduced axonal number or packing density, abnormal glial cell arrangement or function, and reduced myelin.

show abstract

White matter abnormalities in bipolar disorder and schizophrenia detected using diffusion tensor magnetic resonance imaging

Cited by 45 publications

References 0 publications

The effects of a neuregulin 1 variant on white matter density and integrity

The effects of a neuregulin 1 variant on white matter density and integrity

Investigation of Anatomical Thalamo-Cortical Connectivity and fMRI Activation in Schizophrenia

Altered Interhemispheric and Temporal Lobe White Matter Microstructural Organization in Severe Chronic Schizophrenia

Contact Info

Product

Resources

About