White matter abnormalities associated with ADHD outcomes in adulthood

Versace, Amelia; Jones, Neil P.; Joseph, Heather M.; Lindstrom, Rachel; Wilson, Timothy H.; Santos, João Paulo Lima; Gnagy, Elizabeth M.; Pelham, William E.; Ladouceur, Cecile D.; Molina, Brooke S. G.

doi:10.1038/s41380-021-01153-7

Cited by 16 publications

(7 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…ADHD has been associated with white matter abnormalities in a range of tracts, including (but not limited to) bilateral ILF ( Chen et al, 2016 ), and specific associations between persistent symptoms of inattention and ILF have been reported both in children ( Svatkova et al, 2016 ) and adults ( Versace et al, 2021 , Konrad et al, 2012 ) (although it is worth noting that other tracts have also been implicated in inattentive symptoms in ADHD cohorts ( Shaw et al, 2015 ; Wu et al, 2014 ). It has been suggested that altered connectivity via ILF may contribute to inattentive symptoms due to resultant perturbation of visually guided attentional processes ( Versace et al, 2021 ), a notion supported by findings of ILF involvement in developmental learning difficulties that may be related to visual attention alterations ( Chokron et al, 2021 ). Our findings suggest that the structural alterations in right ILF seen in TSC may underlie the severity of inattention in this population.…”

Section: Discussionmentioning

confidence: 99%

White matter disruptions related to inattention and autism spectrum symptoms in tuberous sclerosis complex

Vanes

Tye

Tournier

et al. 2022

NeuroImage: Clinical

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

White matter disruptions related to inattention and autism spectrum symptoms in tuberous sclerosis complex

Vanes

Tye

Tournier

et al. 2022

NeuroImage: Clinical

View full text Add to dashboard Cite

“…The decline of FA in SLF continued into adulthood and did not recover as symptoms got better. While Silk et al ( 36 ) found increased FA in the SLF in ADHD patients, some other studies found no significant difference compared to healthy controls ( 37 – 41 ). Further studies are needed to investigate abnormalities in the SLF in ADHD patients.…”

Section: Introductionmentioning

confidence: 92%

Segmental abnormalities of superior longitudinal fasciculus microstructure in patients with schizophrenia, bipolar disorder, and attention-deficit/hyperactivity disorder: An automated fiber quantification tractography study

Jin

Zuo

et al. 2022

Front. Psychiatry

View full text Add to dashboard Cite

IntroductionSuperior longitudinal fasciculus (SLF) is a white matter (WM) tract that connects the frontal, parietal and temporal lobes. SLF integrity has been widely assessed in neuroimaging studies of psychiatric disorders, such as schizophrenia (SZ), bipolar disorder (BD), and attention-deficit/hyperactivity disorder (ADHD). However, prior studies have revealed inconsistent findings and comparisons across disorders have not been fully examined.MethodsHere, we obtained data for 113 patients (38 patients with SZ, 40 with BD, 35 with ADHD) and 94 healthy controls from the UCLA Consortium for Neuropsychiatric Phenomic LA5c dataset. We assessed the integrity of 20 major WM tracts with a novel segmentation method by automating fiber tract quantification (AFQ). The AFQ divides each tract into 100 equal parts along the direction of travel, with fractional anisotropy (FA) of each part taken as a characteristic. Differences in FA among the four groups were examined.ResultsCompared to healthy controls, patients with SZ showed significantly lower FA in the second half (51–100 parts) of the SLF. No differences were found between BD and healthy controls, nor between ADHD and healthy controls. Results also demonstrated that patients with SZ showed FA reduction in the second half of the SLF relative to patients with BP. Moreover, greater FA in patients in SLF was positively correlated with the manic-hostility score of the Brief Psychiatry Rating scale.DiscussionThese findings indicated that differences in focal changes in SLF might be a key neurobiological abnormality contributing to characterization of these psychiatric disorders.

show abstract

“…Also, increases of gray matter have been found in ASD (Cauda et al, 2011) and in creative individuals . Moreover, white matter structures are linked to creativity in schizophrenia (Sampedro et al, 2020) and the creativity reported in ADHD may also be linked to white matter abnormalities in ADHD brain (Versace et al, 2021). Researchers also started to study functional connectivity in big-c creativity in artists and scientists and found some anomalies (Anderson et al, 2022;Andreasen & Ramchandran, 2012;Japardi et al, 2018).…”

Section: D) Cognitive Disinhibition and Latent Inhibition Deficitmentioning

confidence: 99%

ASD and ADHD as syndromes of high creativity - Le TSA et le TDAH comme syndromes de haute créativité

Rebecchi¹

2023

Preprint

View full text Add to dashboard Cite

Attention-Deficit Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD) really appeared in their current meaning under the labels "Attention Deficit Disorder" and "Infantile Autism" in the third version of the Diagnostic and Statistical Manual of Mental Disorders in 1980. Thus, their pathological and psychiatric status was officially established. Researchers therefore focus mainly on deficits and impairments and forget the other side of the coin, namely the positive aspects and strengths of autistic and hyperactive people. However, for several decades, the positive aspects and strengths have been noted by scientists and expressed by the individuals concerned. The central question of this article is to question the creative and scientific skills of ADHD and ASD individuals. This article highlights the links between psychopathologies and creativity, the relationships and overlaps between ASD and creativity, ADHD and creativity, as well as a review of physiological evidence of the common characteristics of ASD-ADHD-creativity in particular concerning lateralization of brain functions and cerebral asymmetries, variations in concentrations and receptors in neurotransmission systems and gene related, attentional states of consciousness and default mode network, cognitive disinhibition and latent inhibition deficit, hyperconnectivity and highly cerebral excitability, personality and temperament.I propose a rereading of ADHD and ASD which are usually analyzed through a localization model highlighting some non-pathognomonic behaviors and from a pathological angle. Here, the connectionist model highlights variations in the concentrations and receptors of γ-aminobutyric acid, acetylcholine, dopamine, glutamic acid and serotonin, thus causing changes in basic cognitive functioning and increased creative thinking. This attempt to analyze the characteristics of ADHD and ASD in cognitive neurogenetics highlights that this creative thinking is pervasive and will materialize in the individuals involved in their areas of interest and expertise (causing goal-oriented motivation in ADHD and developed to understand the environment, making the world coherent, socializing, expressing oneself in ASD) at the levels of divergent and convergent thinking (related to boredom intolerance, impulsivity and spontaneous thinking in ADHD and attention to detail, abstract and schematic thinking, extensive systematization and reintegration abilities, hyperfocusing abilities, and compulsive ritualistic repetition in ASD), and a specific default mode network and the ability to switch between attentional states of consciousness (leading to high sensitivity and risk-seeking situations in ADHD and to environmental ordering in ASD) from real-life situations, and open-ended and abstract problems and situations.Thus, these characteristics could allow ADHD and ASD to be considered as high creativity syndromes, provoking an irrepressible creative impulse in ADHD and ASD individuals, and creating a double stigma related to the pathologization of their difference and the social treatment reserved for creative people.RésuméLe trouble déficitaire de l'attention avec ou sans hyperactivité (TDAH) et le trouble du spectre autistique (TSA) sont véritablement apparus dans leur acception actuelle sous les étiquettes « trouble déficitaire de l'attention » et « autisme infantile » dans la troisième version du Manuel diagnostique et statistique des troubles mentaux en 1980. Ainsi, leur statut pathologique et psychiatrique a été officiellement établi. Les chercheurs se concentrent donc principalement sur les déficits et les déficiences et oublient l'autre côté de la médaille, à savoir les aspects positifs et les forces des personnes autistes et hyperactives. Cependant, depuis plusieurs décennies, les aspects positifs et les forces ont été notés par les scientifiques et exprimés par les personnes concernées. La question centrale de cet article est de s'interroger sur les compétences créatives et scientifiques des individus TDAH et TSA. Cet article met en évidence les liens entre les psychopathologies et la créativité, les relations et les chevauchements entre les TSA et la créativité, le TDAH et la créativité, ainsi qu'un examen des preuves physiologiques des caractéristiques communes des TSA-TDAH-créativité, notamment au niveau de la latéralisation des fonctions cérébrales et les asymétries cérébrales, des variations des concentrations et des récepteurs dans les systèmes de neurotransmission et les gènes associés, des états de conscience attentionnels et du réseau du mode par défaut, de la désinhibition cognitive et du déficit d'inhibition latent, de l'hyperconnectivité et de la forte excitabilité cérébrale, de la personnalité et du tempérament. (...)

show abstract

White matter abnormalities associated with ADHD outcomes in adulthood

Cited by 16 publications

References 66 publications

White matter disruptions related to inattention and autism spectrum symptoms in tuberous sclerosis complex

White matter disruptions related to inattention and autism spectrum symptoms in tuberous sclerosis complex

Segmental abnormalities of superior longitudinal fasciculus microstructure in patients with schizophrenia, bipolar disorder, and attention-deficit/hyperactivity disorder: An automated fiber quantification tractography study

ASD and ADHD as syndromes of high creativity - Le TSA et le TDAH comme syndromes de haute créativité

Contact Info

Product

Resources

About